PMID- 34307604
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210727
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 9
IP  - 20
DP  - 2021 Jul 16
TI  - Type 2 diabetes mellitus increases liver transplant-free mortality in patients 
      with cirrhosis: A systematic review and meta-analysis.
PG  - 5514-5525
LID - 10.12998/wjcc.v9.i20.5514 [doi]
AB  - BACKGROUND: The impact of type 2 diabetes mellitus (T2DM) on the prognosis and 
      complications of liver cirrhosis is not fully clarified. AIM: To clarify the 
      mortality and related risk factors as well as complications in cirrhotic patients 
      with T2DM. METHODS: We searched PubMed, EMBASE, and the Cochrane Library from 
      their inception to December 1, 2020 for cohort studies comparing liver 
      transplant-free mortality, hepatocellular carcinoma (HCC), ascites, spontaneous 
      bacterial peritonitis (SBP), variceal bleeding, and hepatic encephalopathy (HE) 
      in cirrhotic patients with vs without T2DM. Odds ratios (ORs) were combined by 
      using fixed-effects or random-effects models with RevMan software. RESULTS: The 
      database search generated a total of 17 cohort studies that met the inclusion 
      criteria. Among these studies, eight reported the risk of mortality, and eight 
      reported the risk of HCC. Three studies provided SBP rates, and two documented 
      ascites rates. Four articles focused on HE rates, and three focused on variceal 
      bleeding rates. Meta-analysis indicated that T2DM was significantly associated 
      with an increased risk of liver transplant-free mortality [OR: 1.28, 95% 
      confidence intervals (CI): 1.16-1.41, P < 0.0001] and HCC incidence (OR: 1.82, 
      95%CI: 1.32-2.51, P = 0.003). The risk of SBP was not significantly increased 
      (OR: 1.16 95%CI: 0.86-1.57, P = 0.34). Additionally, T2DM did not significantly 
      increase HE (OR: 1.31 95%CI: 0.97-1.77, P = 0.08), ascites (OR: 1.11 95%CI: 
      0.84-1.46, P = 0.46), and variceal bleeding (OR: 1.34, 95%CI: 0.99-1.82, P = 
      0.06). CONCLUSION: The findings suggest that cirrhotic patients with T2DM have a 
      poor prognosis and high risk of HCC. T2DM may not be associated with an increased 
      risk of SBP, variceal bleeding, ascites, or HE in cirrhotic patients with T2DM.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Liu, Zi-Jin
AU  - Liu ZJ
AD  - Department of Gastroenterology and Hepatology, Beijing You'an Hospital Affiliated 
      to Capital Medical University, Beijing 100069, China.
FAU - Yan, Yi-Jie
AU  - Yan YJ
AD  - Department of Gastroenterology and Hepatology, Beijing You'an Hospital Affiliated 
      to Capital Medical University, Beijing 100069, China.
FAU - Weng, Hong-Lei
AU  - Weng HL
AD  - Department of Medicine II, Section Molecular Hepatology, Medical Faculty 
      Mannheim, Heidelberg University, Mannheim 68167, Germany.
FAU - Ding, Hui-Guo
AU  - Ding HG
AD  - Department of Gastroenterology and Hepatology, Beijing You'an Hospital Affiliated 
      to Capital Medical University, Beijing 100069, China. dinghuiguo@ccmu.edu.cn.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC8281398
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Hepatocellular carcinoma
OT  - Liver cirrhosis
OT  - Meta-analysis
OT  - Mortality
COIS- Conflict-of-interest statement: The authors declare no conflict of interest for 
      this article.
EDAT- 2021/07/27 06:00
MHDA- 2021/07/27 06:01
PMCR- 2021/07/16
CRDT- 2021/07/26 06:39
PHST- 2021/02/09 00:00 [received]
PHST- 2021/04/27 00:00 [revised]
PHST- 2021/05/20 00:00 [accepted]
PHST- 2021/07/26 06:39 [entrez]
PHST- 2021/07/27 06:00 [pubmed]
PHST- 2021/07/27 06:01 [medline]
PHST- 2021/07/16 00:00 [pmc-release]
AID - 10.12998/wjcc.v9.i20.5514 [doi]
PST - ppublish
SO  - World J Clin Cases. 2021 Jul 16;9(20):5514-5525. doi: 10.12998/wjcc.v9.i20.5514.