PMID- 34307899
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 2398-385X (Electronic)
IS  - 2398-385X (Linking)
VI  - 6
IP  - 3
DP  - 2021
TI  - Computerized Assessment of Psychosis Risk.
LID - e210011 [pii]
LID - 10.20900/jpbs.20210011 [doi]
AB  - Early detection and intervention with young people at clinical high risk (CHR) 
      for psychosis is critical for prevention efforts focused on altering the 
      trajectory of psychosis. Early CHR research largely focused on validating 
      clinical interviews for detecting at-risk individuals; however, this approach has 
      limitations related to: (1) specificity (i.e., only 20% of CHR individuals 
      convert to psychosis) and (2) the expertise and training needed to administer 
      these interviews is limited. The purpose of our study is to develop the 
      computerized assessment of psychosis risk (CAPR) battery, consisting of 
      behavioral tasks that require minimal training to administer, can be administered 
      online, and are tied to the neurobiological systems and computational mechanisms 
      implicated in psychosis. The aims of our study are as follows: (1A) to develop a 
      psychosis-risk calculator through the application of machine learning (ML) 
      methods to the measures from the CAPR battery, (1B) evaluate group differences on 
      the risk calculator score and test the hypothesis that the risk calculator score 
      of the CHR group will differ from help-seeking and healthy controls, (1C) 
      evaluate how baseline CAPR battery performance relates to symptomatic outcome two 
      years later (i.e., conversion and symptomatic worsening). These aims will be 
      explored in 500 CHR participants, 500 help-seeking individuals, and 500 healthy 
      controls across the study sites. This project will provide a next-generation CHR 
      battery, tied to illness mechanisms and powered by cutting-edge computational 
      methods that can be used to facilitate the earliest possible detection of 
      psychosis risk.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Institutes for Policy Research (IPR) and Innovations in Developmental Sciences 
      (DevSci), Departments of Psychology, Psychiatry, Medical Social Sciences, 
      Northwestern University, Evanston, IL 60208, USA.
FAU - Ellman, Lauren M
AU  - Ellman LM
AD  - Department of Psychology, Temple University, Philadelphia, PA 19122, USA.
FAU - Strauss, Gregory P
AU  - Strauss GP
AD  - Departments of Psychology and Neuroscience, University of Georgia, Athens, GA 
      30602, USA.
FAU - Walker, Elaine F
AU  - Walker EF
AD  - Department of Psychology and Program in Neuroscience, Emory University, Atlanta, 
      GA 30322, USA.
FAU - Corlett, Philip R
AU  - Corlett PR
AD  - Department of Psychiatry, Yale University, New Haven, CT 06519, USA.
FAU - Schiffman, Jason
AU  - Schiffman J
AD  - Department of Psychological Science, 4201 Social and Behavioral Sciences Gateway, 
      University of California, Irvine, CA 92697, USA.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, CT 06519, USA.
FAU - Powers, Albert R
AU  - Powers AR
AD  - Department of Psychiatry, Yale University, New Haven, CT 06519, USA.
FAU - Silverstein, Steven M
AU  - Silverstein SM
AD  - Center for Visual Science, Departments of Psychiatry, Neuroscience and 
      Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.
FAU - Waltz, James A
AU  - Waltz JA
AD  - Maryland Psychiatric Research Center, Department of Psychiatry, University of 
      Maryland School of Medicine, Baltimore, MD 21228, USA.
FAU - Zinbarg, Richard
AU  - Zinbarg R
AD  - Department of Psychology, Northwestern University, Evanston, IL 60208, USA.
AD  - The Family Institute at Northwestern University, Evanston, IL 60208, USA.
FAU - Chen, Shuo
AU  - Chen S
AD  - Maryland Psychiatric Research Center, Department of Psychiatry, University of 
      Maryland School of Medicine, Baltimore, MD 21228, USA.
FAU - Williams, Trevor
AU  - Williams T
AD  - Department of Psychology, Northwestern University, Evanston, IL 60208, USA.
FAU - Kenney, Joshua
AU  - Kenney J
AD  - Department of Psychiatry, Yale University, New Haven, CT 06519, USA.
FAU - Gold, James M
AU  - Gold JM
AD  - Maryland Psychiatric Research Center, Department of Psychiatry, University of 
      Maryland School of Medicine, Baltimore, MD 21228, USA.
LA  - eng
GR  - R01 MH112613/MH/NIMH NIH HHS/United States
GR  - R01 MH112612/MH/NIMH NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - R01 MH120089/MH/NIMH NIH HHS/United States
GR  - K23 MH115252/MH/NIMH NIH HHS/United States
GR  - R01 MH120090/MH/NIMH NIH HHS/United States
GR  - R01 MH112545/MH/NIMH NIH HHS/United States
GR  - R01 MH116039/MH/NIMH NIH HHS/United States
GR  - R21 MH119438/MH/NIMH NIH HHS/United States
GR  - R01 MH120091/MH/NIMH NIH HHS/United States
GR  - R01 MH120088/MH/NIMH NIH HHS/United States
GR  - R01 MH120092/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20210629
PL  - England
TA  - J Psychiatr Brain Sci
JT  - Journal of psychiatry and brain science
JID - 101739159
PMC - PMC8302046
MID - NIHMS1720085
OTO - NOTNLM
OT  - behavioral tasks
OT  - clinical high-risk
OT  - computational psychiatry
OT  - computerized assessment
OT  - precision medicine
OT  - prodrome
OT  - psychosis
OT  - risk calculator
OT  - risk screening
OT  - schizophrenia
COIS- CONFLICTS OF INTEREST The authors report no conflicts of interest.
EDAT- 2021/07/27 06:00
MHDA- 2021/07/27 06:01
PMCR- 2021/07/23
CRDT- 2021/07/26 06:43
PHST- 2021/07/26 06:43 [entrez]
PHST- 2021/07/27 06:00 [pubmed]
PHST- 2021/07/27 06:01 [medline]
PHST- 2021/07/23 00:00 [pmc-release]
AID - e210011 [pii]
AID - 10.20900/jpbs.20210011 [doi]
PST - ppublish
SO  - J Psychiatr Brain Sci. 2021;6(3):e210011. doi: 10.20900/jpbs.20210011. Epub 2021 
      Jun 29.