PMID- 34308024
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 6
IP  - 28
DP  - 2021 Jul 20
TI  - Water-Soluble Blue Fluorescent Nonconjugated Polymer Dots from Hyaluronic Acid 
      and Hydrophobic Amino Acids.
PG  - 17890-17901
LID - 10.1021/acsomega.1c01343 [doi]
AB  - Fluorescent polymers have been increasingly investigated to improve their water 
      solubility and biocompatibility to enhance their performance in drug delivery and 
      theranostic applications. However, the environmentally friendly synthesis and 
      dual functionality of such systems remain a challenge due to the complicated 
      synthesis of conventional fluorescent materials. Herein, we generated a novel 
      blue fluorescent polymer dot through chemical conjugation of hydrophobic amino 
      acids to hyaluronic acid (HA) under one-pot green chemistry conditions. These 
      nonconjugated fluorescent polymer dots (NCPDs) are water soluble, nontoxic to 
      cells, have high fluorescence quantum yield, and can be used for in vitro 
      bioimaging. HA-derived NCPDs exhibit excitation wavelength-dependent fluorescent 
      properties. In addition, the NCPDs also show enhanced doxorubicin loading and 
      delivery in naive and drug-resistant breast cancer cells in 2D and 3D tumor 
      cellular systems. These results demonstrate the potential for successful 
      synthetic scale-up and applications for HA-derived NCPDs.
CI  - (c) 2021 The Authors. Published by American Chemical Society.
FAU - Bhattacharya, Deep S
AU  - Bhattacharya DS
AD  - Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 
      Omaha, Nebraska 68198, United States.
FAU - Bapat, Aishwarya
AU  - Bapat A
AD  - Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 
      Omaha, Nebraska 68198, United States.
FAU - Svechkarev, Denis
AU  - Svechkarev D
AUID- ORCID: 0000-0002-4002-6155
AD  - Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 
      Omaha, Nebraska 68198, United States.
FAU - Mohs, Aaron M
AU  - Mohs AM
AUID- ORCID: 0000-0002-9353-5404
AD  - Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 
      Omaha, Nebraska 68198, United States.
AD  - Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, 
      Omaha, Nebraska 68198, United States.
AD  - Department of Biochemistry and Molecular Biology, University of Nebraska Medical 
      Center, Omaha, Nebraska 68198, United States.
LA  - eng
GR  - P20 GM103427/GM/NIGMS NIH HHS/United States
GR  - P30 GM106397/GM/NIGMS NIH HHS/United States
GR  - P30 CA036727/CA/NCI NIH HHS/United States
GR  - R21 CA212500/CA/NCI NIH HHS/United States
GR  - R01 EB019449/EB/NIBIB NIH HHS/United States
PT  - Journal Article
DEP - 20210709
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
EIN - ACS Omega. 2021 Oct 05;6(41):27598. PMID: 34693181
PMC - PMC8296014
COIS- The authors declare no competing financial interest.
EDAT- 2021/07/27 06:00
MHDA- 2021/07/27 06:01
PMCR- 2021/07/09
CRDT- 2021/07/26 06:45
PHST- 2021/03/16 00:00 [received]
PHST- 2021/06/24 00:00 [accepted]
PHST- 2021/07/26 06:45 [entrez]
PHST- 2021/07/27 06:00 [pubmed]
PHST- 2021/07/27 06:01 [medline]
PHST- 2021/07/09 00:00 [pmc-release]
AID - 10.1021/acsomega.1c01343 [doi]
PST - epublish
SO  - ACS Omega. 2021 Jul 9;6(28):17890-17901. doi: 10.1021/acsomega.1c01343. 
      eCollection 2021 Jul 20.