PMID- 34309792
OWN - NLM
STAT- MEDLINE
DCOM- 20211109
LR  - 20211109
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 41
IP  - 12
DP  - 2021 Dec
TI  - Evaluation of the effect of unilateral late blindness on the retina, optic nerve 
      and choroid parameters in the sighted eye.
PG  - 4083-4089
LID - 10.1007/s10792-021-01981-0 [doi]
AB  - BACKGROUND: To investigate whether unilateral late blindness alters the 
      peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), 
      central macular thickness (CMT) and choroidal thickness (CT). METHODS: The 17 
      healthy eyes of 17 monocular patients with late blindness due to isolated eye 
      trauma in one eye and the 19 eyes of 19 healthy individuals were evaluated in 
      this retrospective study. Patients with at least 10 years of monocular blindness, 
      a refractive error between + 1.5 and -1.5 D in the sighted eye, a best-corrected 
      visual acuity of at least 20/20 and an axial length (AL) < 25 mm were included in 
      the study. Following ophthalmologic examination, the RNFL, GCC, CMT and CT values 
      were measured with spectral domain optic tomography (SD-OCT). Those with ocular, 
      systemic or neurological disease that could influence the measured parameters 
      were excluded from the study. RESULTS: A total of 17 (14 males, 3 females) 
      monocular patients [mean age 41.00 +/- 11.95 (24-64)] and 19 (16 males, 3 females) 
      healthy individuals [mean age 39.79 +/- 6.74 (30-56)], similar in age and gender 
      (p = 0.949 and p = 0.881), were included in the study. The mean duration of being 
      monocular was 22.76 +/- 11.76 (10-49) years. No difference was present between the 
      RNFL, GCC, CMT and CT measurements of the monocular patients and the healthy 
      individuals (p = 0.692, p = 0.294, p = 0.113, p = 0.623, respectively). No 
      significant correlation was found between the duration of monocularity and the 
      retinal and optic nerve parameters. CONCLUSION: The results of our study indicate 
      no difference in the optic nerve, retina and choroid OCT findings in the sighted 
      eyes of subjects with long-term monocular blindness compared to subjects with 
      bilateral normal eyes. Although functional and volumetric neuroimaging studies 
      suggest the possibility of compensation in these patients, our findings indicate 
      that this is not at the ocular level.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Oktem, Caglar
AU  - Oktem C
AD  - Department of Ophthalmology, Alaaddin Keykubat University Alanya Education and 
      Research Hospital, 07400, Antalya, Turkey. cglroktm@gmail.com.
FAU - Aslan, Fatih
AU  - Aslan F
AD  - Department of Ophthalmology, Alaaddin Keykubat University Alanya Education and 
      Research Hospital, 07400, Antalya, Turkey.
FAU - Oktem, Ece Ozdemir
AU  - Oktem EO
AD  - Department of Neurology, Alaaddin Keykubat University Alanya Education and 
      Research Hospital, Antalya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210726
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
SB  - IM
MH  - Adult
MH  - Blindness
MH  - Choroid
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers
MH  - *Optic Disk
MH  - Optic Nerve
MH  - Retina
MH  - Retinal Ganglion Cells
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Central macular thickness
OT  - Choroidal thickness
OT  - Ganglion cell complex
OT  - Healthy eye
OT  - Retinal nerve fiber layer
OT  - Unilateral late blindness
EDAT- 2021/07/27 06:00
MHDA- 2021/11/10 06:00
CRDT- 2021/07/26 12:33
PHST- 2020/09/03 00:00 [received]
PHST- 2021/07/16 00:00 [accepted]
PHST- 2021/07/27 06:00 [pubmed]
PHST- 2021/11/10 06:00 [medline]
PHST- 2021/07/26 12:33 [entrez]
AID - 10.1007/s10792-021-01981-0 [pii]
AID - 10.1007/s10792-021-01981-0 [doi]
PST - ppublish
SO  - Int Ophthalmol. 2021 Dec;41(12):4083-4089. doi: 10.1007/s10792-021-01981-0. Epub 
      2021 Jul 26.