PMID- 34309800
OWN - NLM
STAT- MEDLINE
DCOM- 20220425
LR  - 20220425
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 200
IP  - 5
DP  - 2022 May
TI  - Comparison of the Toxic Effects of Pristine and Photocatalytically Used TiO(2) 
      Nanoparticles in Mice.
PG  - 2298-2311
LID - 10.1007/s12011-021-02846-4 [doi]
AB  - TiO(2) nanoparticles used in the photocatalytic degradation of pollutants in 
      water treatment processes undergo physiochemical changes; therefore, their 
      toxicological effects may be potentially different from those of the pristine 
      nanoparticles. This study compared the toxic effects of exposure to pristine and 
      photocatalytically used TiO(2) nanoparticles in mice. To obtain used TiO(2), the 
      nanoparticles were used for photocatalytic degradation of a model pollutant under 
      UV irradiation several times. Two groups of mice were exposed to pristine (PT 
      group) and photocatalytically used TiO(2) (UT group) at three different 
      concentrations (5-20 mg/m(3)) using whole-body exposure chambers (2 h/day, 
      5 days/weeks, 4 weeks). Exposure to both pristine and used TiO(2) increased the 
      levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), 
      alkaline phosphate (ALP), lactate dehydrogenase (LDH), C-reactive protein (CRP), 
      and creatine kinase (CK-MB) significantly. Both exposed groups showed higher 
      levels of WBC, lymphocytes, platelets, hematocrits, hemoglobin, and mean 
      corpuscular volume (MCV) and lower levels of RBC and mean corpuscular hemoglobin 
      concentration (MCHC) in a concentration-dependent manner. In all analyses, there 
      were small non-significant differences between the PT and UT groups. More 
      pathological changes were observed in the lung, kidney, and brain of the UT 
      group, while the PT group showed more pathological effects in the liver and 
      heart. The histological observations indicated that damage was mostly in the form 
      of vascular endothelial injury. These two types of TiO(2) may activate different 
      pathways to promote adverse effects. Further studies are required to evaluate and 
      distinguish the mechanisms through which pristine and used TiO(2) induce 
      toxicity.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Hadei, Mostafa
AU  - Hadei M
AD  - Department of Environmental Health Engineering, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Rabbani, Shahram
AU  - Rabbani S
AD  - Research Center for Advanced Technologies in Cardiovascular Medicine, 
      Cardiovascular Diseases Research Institute, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Nabizadeh, Ramin
AU  - Nabizadeh R
AD  - Department of Environmental Health Engineering, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - Center for Air Pollution Research (CAPR), Institute for Environmental Research 
      (IER), Tehran University of Medical Sciences, Tehran, Iran.
FAU - Mahvi, Amir Hossein
AU  - Mahvi AH
AD  - Department of Environmental Health Engineering, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - Center for Solid Waste Research (CSWR), Institute for Environmental Research 
      (IER), Tehran University of Medical Sciences, Tehran, Iran.
FAU - Mesdaghinia, Alireza
AU  - Mesdaghinia A
AD  - Department of Environmental Health Engineering, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Naddafi, Kazem
AU  - Naddafi K
AD  - Department of Environmental Health Engineering, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran. knadafi@tums.ac.ir.
AD  - Center for Air Pollution Research (CAPR), Institute for Environmental Research 
      (IER), Tehran University of Medical Sciences, Tehran, Iran. knadafi@tums.ac.ir.
LA  - eng
GR  - 98017354/iran national science foundation/
PT  - Journal Article
DEP - 20210726
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase
MH  - Animals
MH  - Aspartate Aminotransferases
MH  - Mice
MH  - *Nanoparticles/toxicity
MH  - *Titanium/toxicity
OTO - NOTNLM
OT  - Environmental toxicology
OT  - Inhalation exposure
OT  - Nanotoxicity
OT  - TiO2 nanoparticles
OT  - Toxicological assessment
OT  - Water treatment
EDAT- 2021/07/27 06:00
MHDA- 2022/04/26 06:00
CRDT- 2021/07/26 12:33
PHST- 2021/05/25 00:00 [received]
PHST- 2021/07/17 00:00 [accepted]
PHST- 2021/07/27 06:00 [pubmed]
PHST- 2022/04/26 06:00 [medline]
PHST- 2021/07/26 12:33 [entrez]
AID - 10.1007/s12011-021-02846-4 [pii]
AID - 10.1007/s12011-021-02846-4 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2022 May;200(5):2298-2311. doi: 10.1007/s12011-021-02846-4. 
      Epub 2021 Jul 26.