PMID- 34310121 OWN - NLM STAT- MEDLINE DCOM- 20220209 LR - 20240403 IS - 1520-5126 (Electronic) IS - 0002-7863 (Print) IS - 0002-7863 (Linking) VI - 143 IP - 30 DP - 2021 Aug 4 TI - Order from Disorder with Intrinsically Disordered Peptide Amphiphiles. PG - 11879-11888 LID - 10.1021/jacs.1c06133 [doi] AB - Amphiphilic molecules and their self-assembled structures have long been the target of extensive research due to their potential applications in fields ranging from materials design to biomedical and cosmetic applications. Increasing demands for functional complexity have been met with challenges in biochemical engineering, driving researchers to innovate in the design of new amphiphiles. An emerging class of molecules, namely, peptide amphiphiles, combines key advantages and circumvents some of the disadvantages of conventional phospholipids and block copolymers. Herein, we present new peptide amphiphiles composed of an intrinsically disordered peptide conjugated to two variants of hydrophobic dendritic domains. These molecules, termed intrinsically disordered peptide amphiphiles (IDPA), exhibit a sharp pH-induced micellar phase-transition from low-dispersity spheres to extremely elongated worm-like micelles. We present an experimental characterization of the transition and propose a theoretical model to describe the pH-response. We also present the potential of the shape transition to serve as a mechanism for the design of a cargo hold-and-release application. Such amphiphilic systems demonstrate the power of tailoring the interactions between disordered peptides for various stimuli-responsive biomedical applications. FAU - Jacoby, Guy AU - Jacoby G AUID- ORCID: 0000-0002-7559-542X AD - Raymond & Beverly Sackler School of Physics & Astronomy, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for Physics & Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for NanoTechnology & NanoScience, Tel Aviv Univeristy, Tel Aviv 6997801, Israel. FAU - Segal Asher, Merav AU - Segal Asher M AUID- ORCID: 0000-0003-0088-9033 AD - The Center for Physics & Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for NanoTechnology & NanoScience, Tel Aviv Univeristy, Tel Aviv 6997801, Israel. AD - Raymond & Beverly Sackler School of Chemistry, Tel Aviv University, Tel Aviv 6997801, Israel. FAU - Ehm, Tamara AU - Ehm T AD - Raymond & Beverly Sackler School of Physics & Astronomy, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for Physics & Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for NanoTechnology & NanoScience, Tel Aviv Univeristy, Tel Aviv 6997801, Israel. AD - Faculty of Physics and Center for NanoScience, Ludwig-Maximilians-Universitat, Munchen D-80539, Germany. FAU - Abutbul Ionita, Inbal AU - Abutbul Ionita I AD - CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel. FAU - Shinar, Hila AU - Shinar H AUID- ORCID: 0000-0001-6973-8757 AD - Raymond & Beverly Sackler School of Physics & Astronomy, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for Physics & Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for NanoTechnology & NanoScience, Tel Aviv Univeristy, Tel Aviv 6997801, Israel. FAU - Azoulay-Ginsburg, Salome AU - Azoulay-Ginsburg S AUID- ORCID: 0000-0002-9140-5331 AD - Raymond & Beverly Sackler School of Chemistry, Tel Aviv University, Tel Aviv 6997801, Israel. FAU - Zemach, Ido AU - Zemach I AUID- ORCID: 0000-0001-9031-9952 AD - Raymond & Beverly Sackler School of Physics & Astronomy, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for Physics & Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for NanoTechnology & NanoScience, Tel Aviv Univeristy, Tel Aviv 6997801, Israel. FAU - Koren, Gil AU - Koren G AUID- ORCID: 0000-0002-2596-6472 AD - Raymond & Beverly Sackler School of Physics & Astronomy, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for Physics & Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for NanoTechnology & NanoScience, Tel Aviv Univeristy, Tel Aviv 6997801, Israel. FAU - Danino, Dganit AU - Danino D AD - CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel. AD - Guangdong-Technion Israel Institute of Technology, Shantou, Guangdong Province 515063, China. FAU - Kozlov, Michael M AU - Kozlov MM AD - The Center for Physics & Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel. AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. FAU - Amir, Roey J AU - Amir RJ AUID- ORCID: 0000-0002-8502-3302 AD - The Center for Physics & Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for NanoTechnology & NanoScience, Tel Aviv Univeristy, Tel Aviv 6997801, Israel. AD - Raymond & Beverly Sackler School of Chemistry, Tel Aviv University, Tel Aviv 6997801, Israel. FAU - Beck, Roy AU - Beck R AUID- ORCID: 0000-0003-3121-4530 AD - Raymond & Beverly Sackler School of Physics & Astronomy, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for Physics & Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel. AD - The Center for NanoTechnology & NanoScience, Tel Aviv Univeristy, Tel Aviv 6997801, Israel. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210726 PL - United States TA - J Am Chem Soc JT - Journal of the American Chemical Society JID - 7503056 RN - 0 (Intrinsically Disordered Proteins) RN - 0 (Micelles) RN - 0 (Surface-Active Agents) SB - IM MH - Hydrogen-Ion Concentration MH - Intrinsically Disordered Proteins/*chemistry MH - Micelles MH - Particle Size MH - Protein Conformation MH - Surface-Active Agents/*chemistry PMC - PMC8397319 COIS- The authors declare no competing financial interest. EDAT- 2021/07/27 06:00 MHDA- 2022/02/10 06:00 PMCR- 2021/08/27 CRDT- 2021/07/26 17:13 PHST- 2021/07/27 06:00 [pubmed] PHST- 2022/02/10 06:00 [medline] PHST- 2021/07/26 17:13 [entrez] PHST- 2021/08/27 00:00 [pmc-release] AID - 10.1021/jacs.1c06133 [doi] PST - ppublish SO - J Am Chem Soc. 2021 Aug 4;143(30):11879-11888. doi: 10.1021/jacs.1c06133. Epub 2021 Jul 26.