PMID- 34310502
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20230413
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 53
IP  - 12
DP  - 2021 Dec 1
TI  - Chronic Exercise Protects against the Progression of Renal Cyst Growth and 
      Dysfunction in Rats with Polycystic Kidney Disease.
PG  - 2485-2494
LID - 10.1249/MSS.0000000000002737 [doi]
AB  - INTRODUCTION: Polycystic kidney disease (PKD) is a genetic disorder characterized 
      by the progressive enlargement of renal epithelial cysts and renal dysfunction. 
      Previous studies have reported the beneficial effects of chronic exercise on 
      chronic kidney disease. However, the effects of chronic exercise have not been 
      fully examined in PKD patients or models. The effects of chronic exercise on the 
      progression of PKD were investigated in a polycystic kidney (PCK) rat model. 
      METHODS: Six-week-old male PCK rats were divided into a sedentary group and an 
      exercise group. The exercise group underwent forced treadmill exercise for 12 wk 
      (28 m.min-1, 60 min.d-1, 5 d.wk-1). After 12 wk, renal function and histology 
      were examined, and signaling cascades of PKD progression, including arginine 
      vasopressin (AVP), were investigated. RESULTS: Chronic exercise reduced the 
      excretion of urinary protein, liver-type fatty acid-binding protein, plasma 
      creatinine, urea nitrogen, and increased plasma irisin and urinary AVP excretion. 
      Chronic exercise also slowed renal cyst growth, glomerular damage, and 
      interstitial fibrosis and led to reduced Ki-67 expression. Chronic exercise had 
      no effect on cAMP content but decreased the renal expression of B-Raf and reduced 
      the phosphorylation of extracellular signal-regulated kinase (ERK), mammalian 
      target of rapamycin (mTOR), and S6. CONCLUSION: Chronic exercise slows renal cyst 
      growth and damage in PCK rats, despite increasing AVP, with the downregulation of 
      the cAMP/B-Raf/ERK and mTOR/S6 pathways in the kidney of PCK rats.
CI  - Copyright (c) 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American College of Sports Medicine.
FAU - Qiu, Jiahe
AU  - Qiu J
AD  - Department of Internal Medicine and Rehabilitation Science, Tohoku University 
      Graduate School of Medicine, Sendai, JAPAN.
FAU - Sato, Yoichi
AU  - Sato Y
AD  - Department of Internal Medicine and Rehabilitation Science, Tohoku University 
      Graduate School of Medicine, Sendai, JAPAN.
FAU - Xu, Lusi
AU  - Xu L
FAU - Miura, Takahiro
AU  - Miura T
AD  - Department of Internal Medicine and Rehabilitation Science, Tohoku University 
      Graduate School of Medicine, Sendai, JAPAN.
FAU - Kohzuki, Masahiro
AU  - Kohzuki M
AD  - Department of Internal Medicine and Rehabilitation Science, Tohoku University 
      Graduate School of Medicine, Sendai, JAPAN.
FAU - Ito, Osamu
AU  - Ito O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Disease Models, Animal
MH  - *Disease Progression
MH  - Humans
MH  - Physical Exertion/*physiology
MH  - Polycystic Kidney Diseases/*pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC8594502
EDAT- 2021/07/27 06:00
MHDA- 2022/02/15 06:00
PMCR- 2021/11/16
CRDT- 2021/07/26 17:23
PHST- 2021/07/27 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
PHST- 2021/07/26 17:23 [entrez]
PHST- 2021/11/16 00:00 [pmc-release]
AID - 00005768-202112000-00003 [pii]
AID - MSSE_210161 [pii]
AID - 10.1249/MSS.0000000000002737 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2021 Dec 1;53(12):2485-2494. doi: 
      10.1249/MSS.0000000000002737.