PMID- 34310896
OWN - NLM
STAT- MEDLINE
DCOM- 20220221
LR  - 20240226
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 99
IP  - 12
DP  - 2021 Dec
TI  - The S1PR1 agonist SEW2871 promotes the survival of skin flap.
PG  - 1280-1287
LID - 10.1139/cjpp-2021-0006 [doi]
AB  - Skin flap transfer is an important method to repair and reconstruct various 
      tissue defects; however, avascular necrosis largely affects the success of flap 
      transfer. The sphingosine 1-phosphate receptor 1 (S1PR1) agonist SEW2871 has been 
      proven to ameliorate ischemic injury; however, its effect on flap survival has 
      not been reported. In this study, an experimental skin flap model was established 
      in rats to investigate the roles of SEW2871. The results indicated that SEW2871 
      greatly increased the survival of the skin flap, alleviated pathological injury, 
      promoted the angiogenesis, and inhibited cells apoptosis in skin flap tissues. 
      SEW2871 activated S1PR1 downstream signaling pathways, including heat shock 
      protein 27 (HSP27), extracellular regulated protein kinases (ERK), and protein 
      kinase B (Akt). In addition, SEW2871 promoted the expression of S1PR1. These 
      findings may provide novel insights for skin flap transfer.
FAU - Zhang, Dongdong
AU  - Zhang D
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
FAU - Qi, Dongxu
AU  - Qi D
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
FAU - Xu, Yi
AU  - Xu Y
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
FAU - Hu, Chunhe
AU  - Hu C
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
FAU - Zhang, Xiao
AU  - Zhang X
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
FAU - Yang, Qingjian
AU  - Yang Q
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
FAU - Shang, Zikun
AU  - Shang Z
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
FAU - Zhang, Guisheng
AU  - Zhang G
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
AD  - Department of Hand Surgery, The Third Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050051, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210726
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 0 (HSP27 Heat-Shock Proteins)
RN  - 0 (Oxadiazoles)
RN  - 0 (S1PR1 protein, rat)
RN  - 0 (SEW2871)
RN  - 0 (Sphingosine-1-Phosphate Receptors)
RN  - 0 (Thiophenes)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Angiogenesis Inducing Agents
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Gene Expression/drug effects
MH  - Graft Survival/*drug effects/*genetics
MH  - HSP27 Heat-Shock Proteins/metabolism
MH  - Oxadiazoles/*pharmacology
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects/genetics
MH  - Skin/*blood supply/pathology
MH  - Skin Transplantation/*methods
MH  - Sphingosine-1-Phosphate Receptors/genetics/metabolism/*physiology
MH  - Surgical Flaps/blood supply/*transplantation
MH  - Thiophenes/*pharmacology
MH  - Rats
OTO - NOTNLM
OT  - angiogenesis
OT  - angiogenese
OT  - apoptose
OT  - apoptosis
OT  - lambeau cutane
OT  - skin flap
OT  - sphingosine 1-phosphate
EDAT- 2021/07/27 06:00
MHDA- 2022/02/22 06:00
CRDT- 2021/07/26 20:09
PHST- 2021/07/27 06:00 [pubmed]
PHST- 2022/02/22 06:00 [medline]
PHST- 2021/07/26 20:09 [entrez]
AID - 10.1139/cjpp-2021-0006 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2021 Dec;99(12):1280-1287. doi: 10.1139/cjpp-2021-0006. 
      Epub 2021 Jul 26.