PMID- 34311227
OWN - NLM
STAT- MEDLINE
DCOM- 20211229
LR  - 20211229
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 92
DP  - 2021 Aug
TI  - Higher concentrations of vitamin D in Canadian children with juvenile idiopathic 
      arthritis compared to healthy controls are associated with more frequent use of 
      vitamin D supplements and season of birth.
PG  - 139-149
LID - S0271-5317(21)00029-4 [pii]
LID - 10.1016/j.nutres.2021.05.007 [doi]
AB  - A number of studies have demonstrated that patients with autoimmune disease have 
      lower levels of vitamin D prompting speculation that vitamin D might suppress 
      inflammation and immune responses in children with juvenile idiopathic arthritis 
      (JIA).  The objective of this study was to compare vitamin D levels in children 
      with JIA at disease onset with healthy children. We hypothesized that children 
      and adolescents with JIA have lower vitamin D levels than healthy children and 
      adolescents. Data from a Canadian cohort of children with new-onset JIA (n= 164, 
      data collection 2007-2012) were compared to Canadian Health Measures Survey 
      (CHMS) data (n=4027, data collection 2007-2011). We compared 25-hydroxy vitamin D 
      (25(OH)D) concentrations with measures of inflammation, vitamin D supplement use, 
      milk intake, and season of birth. Mean 25(OH)D level was significantly higher in 
      patients with JIA (79 +/- 3.1 nmol/L) than in healthy controls (68 +/- 1.8 nmol/L P 
      <.05). Patients with JIA more often used vitamin D containing supplements (50% 
      vs. 7%; P <.05). The prevalence of 25(OH)D deficiency (<30 nmol/L) was 6% for 
      both groups. Children with JIA with 25(OH)D deficiency or insufficiency (<50 
      nmol/L) had higher C-reactive protein levels. Children with JIA were more often 
      born in the fall and winter compared to healthy children. In contrast to earlier 
      studies, we found vitamin D levels in Canadian children with JIA were higher 
      compared to healthy children and associated with more frequent use of vitamin D 
      supplements. Among children with JIA, low vitamin D levels were associated with 
      indicators of greater inflammation.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Finch, Sarah L
AU  - Finch SL
AD  - University of Saskatchewan, Saskatoon, Canada; University of Prince Edward 
      Island, Charlottetown, Canada.
FAU - Rosenberg, Alan M
AU  - Rosenberg AM
AD  - University of Saskatchewan, Saskatoon, Canada. Electronic address: 
      alan.rosenberg@usask.ca.
FAU - Kusalik, Anthony J
AU  - Kusalik AJ
AD  - University of Saskatchewan, Saskatoon, Canada.
FAU - Maleki, Farhad
AU  - Maleki F
AD  - University of Saskatchewan, Saskatoon, Canada.
FAU - Rezaei, Elham
AU  - Rezaei E
AD  - University of Saskatchewan, Saskatoon, Canada.
FAU - Baxter-Jones, Adam
AU  - Baxter-Jones A
AD  - University of Saskatchewan, Saskatoon, Canada.
FAU - Benseler, Susanne
AU  - Benseler S
AD  - Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, 
      Calgary, Canada.
FAU - Boire, Gilles
AU  - Boire G
AD  - University of Sherbrooke, Sherbrooke, Canada.
FAU - Cabral, David
AU  - Cabral D
AD  - BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
FAU - Campillo, Sarah
AU  - Campillo S
AD  - McGill University Health Center, Montreal, Canada.
FAU - Chedeville, Gaelle
AU  - Chedeville G
AD  - McGill University Health Center, Montreal, Canada.
FAU - Chetaille, Anne-Laure
AU  - Chetaille AL
AD  - le Centre Hospitalier Universitaire de Quebec, Quebec, Canada.
FAU - Dancey, Paul
AU  - Dancey P
AD  - Janeway Children's Health and Rehabilitation Centre, St. John's, Canada.
FAU - Duffy, Ciaran
AU  - Duffy C
AD  - Children's Hospital of Eastern Ontario, Ottawa, Canada.
FAU - Duffy, Karen Watanabe
AU  - Duffy KW
AD  - Children's Hospital of Eastern Ontario, Ottawa, Canada.
FAU - Guzman, Jaime
AU  - Guzman J
AD  - BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
FAU - Houghton, Kristin
AU  - Houghton K
AD  - BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
FAU - Huber, Adam M
AU  - Huber AM
AD  - IWK Health Centre and Dalhousie University, Halifax, Canada.
FAU - Jurencak, Roman
AU  - Jurencak R
AD  - Children's Hospital of Eastern Ontario, Ottawa, Canada.
FAU - Lang, Bianca
AU  - Lang B
AD  - IWK Health Centre and Dalhousie University, Halifax, Canada.
FAU - Laxer, Ron M
AU  - Laxer RM
AD  - The University of Toronto and The Hospital for Sick Children, Toronto, Canada.
FAU - Morishita, Kimberly
AU  - Morishita K
AD  - BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
FAU - Oen, Kiem G
AU  - Oen KG
AD  - University of Manitoba, Winnipeg, Canada.
FAU - Petty, Ross E
AU  - Petty RE
AD  - BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
FAU - Ramsey, Suzanne E
AU  - Ramsey SE
AD  - IWK Health Centre and Dalhousie University, Halifax, Canada.
FAU - Roth, Johannes
AU  - Roth J
AD  - Children's Hospital of Eastern Ontario, Ottawa, Canada.
FAU - Schneider, Rayfel
AU  - Schneider R
AD  - The University of Toronto and The Hospital for Sick Children, Toronto, Canada.
FAU - Scuccimarri, Rosie
AU  - Scuccimarri R
AD  - McGill University Health Center, Montreal, Canada.
FAU - Stringer, Elizabeth
AU  - Stringer E
AD  - IWK Health Centre and Dalhousie University, Halifax, Canada.
FAU - Tse, Shirley M L
AU  - Tse SML
AD  - The University of Toronto and The Hospital for Sick Children, Toronto, Canada.
FAU - Tucker, Lori B
AU  - Tucker LB
AD  - BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
FAU - Turvey, Stuart E
AU  - Turvey SE
AD  - BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
FAU - Szafron, Michael
AU  - Szafron M
AD  - University of Saskatchewan, Saskatoon, Canada.
FAU - Whiting, Susan
AU  - Whiting S
AD  - University of Saskatchewan, Saskatoon, Canada.
FAU - Yeung, Rae Sm
AU  - Yeung RS
AD  - The University of Toronto and The Hospital for Sick Children, Toronto, Canada.
FAU - Vatanparast, Hassan
AU  - Vatanparast H
AD  - University of Saskatchewan, Saskatoon, Canada. Electronic address: 
      vatan.h@usask.ca.
CN  - BBOP Study Group
LA  - eng
GR  - FRN 82517/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210613
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 1406-16-2 (Vitamin D)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Animals
MH  - Arthritis, Juvenile/*blood/complications/immunology
MH  - Autoimmune Diseases
MH  - C-Reactive Protein/metabolism
MH  - Canada/epidemiology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - *Dietary Supplements
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Inflammation/etiology/metabolism
MH  - Male
MH  - Milk
MH  - *Parturition
MH  - *Seasons
MH  - Vitamin D/analogs & derivatives/*blood/therapeutic use
MH  - Vitamin D Deficiency/*blood/complications/drug therapy/immunology
OTO - NOTNLM
OT  - Arthritis
OT  - Childhood arthritis
OT  - Inflamation
OT  - Juvenile idiopathic arthritis
OT  - Vitamin D
EDAT- 2021/07/27 06:00
MHDA- 2021/12/30 06:00
CRDT- 2021/07/26 20:20
PHST- 2020/10/02 00:00 [received]
PHST- 2021/05/05 00:00 [revised]
PHST- 2021/05/23 00:00 [accepted]
PHST- 2021/07/27 06:00 [pubmed]
PHST- 2021/12/30 06:00 [medline]
PHST- 2021/07/26 20:20 [entrez]
AID - S0271-5317(21)00029-4 [pii]
AID - 10.1016/j.nutres.2021.05.007 [doi]
PST - ppublish
SO  - Nutr Res. 2021 Aug;92:139-149. doi: 10.1016/j.nutres.2021.05.007. Epub 2021 Jun 
      13.