PMID- 34314549
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20230302
IS  - 1399-5618 (Electronic)
IS  - 1398-5647 (Print)
IS  - 1398-5647 (Linking)
VI  - 24
IP  - 2
DP  - 2022 Mar
TI  - Bipolar symptoms, somatic burden, and functioning in older-age bipolar disorder: 
      Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder 
      Database project.
PG  - 195-206
LID - 10.1111/bdi.13119 [doi]
AB  - OBJECTIVE: Literature on older-age bipolar disorder (OABD) is limited. This 
      first-ever analysis of the Global Aging & Geriatric Experiments in Bipolar 
      Disorder Database (GAGE-BD) investigated associations among age, BD symptoms, 
      comorbidity, and functioning. METHODS: This analysis used harmonized, baseline, 
      cross-sectional data from 19 international studies (N = 1377). Standardized 
      measures included the Young Mania Rating Scale (YMRS), Hamilton Depression Rating 
      Scale (HAM-D), Montgomery-Asberg Depression Rating Scale (MADRS), and Global 
      Assessment of Functioning (GAF). RESULTS: Mean sample age was 60.8 years 
      (standard deviation [SD] 12.2 years), 55% female, 72% BD I. Mood symptom severity 
      was low: mean total YMRS score of 4.3 (SD 5.4) and moderate-to-severe depression 
      in only 22%. Controlled for sample effects, both manic and depressive symptom 
      severity appeared lower among older individuals (p's < 0.0001). The negative 
      relationship between older age and symptom severity was similar across sexes, but 
      was stronger among those with lower education levels. GAF was mildly impaired 
      (mean =62.0, SD = 13.3) and somatic burden was high (mean =2.42, SD = 1.97). 
      Comorbidity burden was not associated with GAF. However, higher depressive 
      (p < 0.0001) and manic (p < 0.0001) symptoms were associated with lower GAF, most 
      strongly among older individuals. CONCLUSIONS: Findings suggest an attenuation of 
      BD symptoms in OABD, despite extensive somatic burden. Depressive symptom 
      severity was strongly associated with worse functioning in older individuals, 
      underscoring the need for effective treatments of BD depression in older people. 
      This international collaboration lays a path for the development of a better 
      understanding of aging in BD.
CI  - (c) 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Sajatovic, Martha
AU  - Sajatovic M
AUID- ORCID: 0000-0002-3073-668X
AD  - Case Western Reserve University School of Medicine, University Hospitals 
      Cleveland Medical Center, Cleveland, OH, USA.
FAU - Dols, Annemiek
AU  - Dols A
AUID- ORCID: 0000-0003-1964-0318
AD  - GGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam Neuroscience, Amsterdam 
      Public Health Research Institute, Amsterdam, the Netherlands.
FAU - Rej, Soham
AU  - Rej S
AUID- ORCID: 0000-0002-3908-9124
AD  - Lady Davis Institute, McGill University, Montreal, Canada.
FAU - Almeida, Osvaldo P
AU  - Almeida OP
AUID- ORCID: 0000-0002-8689-6199
AD  - University of Western Australia, Perth, Australia.
FAU - Beunders, Alexandra J M
AU  - Beunders AJM
AUID- ORCID: 0000-0001-9620-2579
AD  - GGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam Neuroscience, Amsterdam 
      Public Health Research Institute, Amsterdam, the Netherlands.
FAU - Blumberg, Hilary P
AU  - Blumberg HP
AUID- ORCID: 0000-0002-6363-4698
AD  - Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
FAU - Briggs, Farren B S
AU  - Briggs FBS
AD  - Department of Population and Quantitative Health Sciences, Case Western Reserve 
      University School of Medicine, Cleveland, OH, USA.
FAU - Forester, Brent P
AU  - Forester BP
AD  - Division of Geriatric Psychiatry, McLean Hospital, Belmont, MA, USA.
AD  - Harvard Medical School, Boston, MA, USA.
FAU - Patrick, Regan E
AU  - Patrick RE
AD  - Division of Geriatric Psychiatry, McLean Hospital, Belmont, MA, USA.
FAU - Forlenza, Orestes V
AU  - Forlenza OV
AD  - Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, 
      HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 
      Brazil.
FAU - Gildengers, Ariel
AU  - Gildengers A
AUID- ORCID: 0000-0001-9216-988X
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA, USA.
FAU - Jimenez, Esther
AU  - Jimenez E
AD  - Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, 
      IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
FAU - Vieta, Eduard
AU  - Vieta E
AUID- ORCID: 0000-0002-0548-0053
AD  - Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, 
      IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
FAU - Mulsant, Benoit
AU  - Mulsant B
AD  - Department of Psychiatry, University of Toronto, Center for Addiction and Mental 
      Health, Toronto, ON, Canada.
FAU - Schouws, Sigfried
AU  - Schouws S
AUID- ORCID: 0000-0003-0591-5405
AD  - GGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam, the Netherlands.
FAU - Paans, Nadine
AU  - Paans N
AD  - GGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam Public Health Research 
      Institute, Amsterdam, the Netherlands.
FAU - Strejilevich, Sergio
AU  - Strejilevich S
AUID- ORCID: 0000-0001-8410-7187
AD  - AREA, Assistance and Research in Affective Disorders, Buenos Aires, Argentina.
FAU - Sutherland, Ashley
AU  - Sutherland A
AD  - Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
FAU - Tsai, Shangying
AU  - Tsai S
AUID- ORCID: 0000-0001-5662-0055
AD  - Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
FAU - Wilson, Betsy
AU  - Wilson B
AD  - Case Western Reserve University School of Medicine, Cleveland, OH, USA.
FAU - Eyler, Lisa T
AU  - Eyler LT
AD  - Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
AD  - Desert-Pacific Mental Illness Research Education and Clinical Center, VA San 
      Diego Healthcare System, San Diego, CA, USA.
LA  - eng
GR  - R01 MH113230/MH/NIMH NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - R01 MH084921/MH/NIMH NIH HHS/United States
GR  - R01 MH070902/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210812
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
SB  - IM
MH  - Aged
MH  - Aging
MH  - *Bipolar Disorder/diagnosis/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Medically Unexplained Symptoms
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
PMC - PMC8792096
MID - NIHMS1728236
OTO - NOTNLM
OT  - aging
OT  - bipolar disorder
OT  - depression
OT  - functioning
OT  - mania
OT  - medical burden
EDAT- 2021/07/28 06:00
MHDA- 2022/04/06 06:00
PMCR- 2023/03/01
CRDT- 2021/07/27 17:24
PHST- 2021/06/22 00:00 [revised]
PHST- 2020/11/23 00:00 [received]
PHST- 2021/07/20 00:00 [accepted]
PHST- 2021/07/28 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
PHST- 2021/07/27 17:24 [entrez]
PHST- 2023/03/01 00:00 [pmc-release]
AID - 10.1111/bdi.13119 [doi]
PST - ppublish
SO  - Bipolar Disord. 2022 Mar;24(2):195-206. doi: 10.1111/bdi.13119. Epub 2021 Aug 12.