PMID- 34315133
OWN - NLM
STAT- MEDLINE
DCOM- 20211209
LR  - 20211214
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 14
DP  - 2021 Jul 27
TI  - Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by 
      suppressing inflammation, restoring Th1/Th2 balance, and improving cellular 
      metabolism.
PG  - 18423-18441
LID - 10.18632/aging.203292 [doi]
AB  - We investigated the mechanisms underlying the therapeutic effects of Yiqi Jiemin 
      decoction (YJD), a traditional Chinese medicine (TCM), in the ovalbumin 
      (OVA)-induced allergic rhinitis (AR) model in guinea pigs. YJD significantly 
      decreased infiltration of mast cells and eosinophils into the nasal mucosa of AR 
      model guinea pigs. YJD also increased expression of TGF-beta in the nasal mucosa, 
      restored the balance of Th1/Th2 immune cell responses, and decreased serum levels 
      of various pro-inflammatory mediators, including histamine (HA), neuropeptide Y 
      (NPY), acetylcholine (ACH), norepinephrine and immunoglobulin E (IgE). Metabolic 
      analyses using liquid chromatography coupled with high-resolution mass 
      spectrometry revealed that YJD improved cellular metabolism in AR model guinea 
      pigs and increased serum levels of glycocholic acid while decreasing levels 
      1-palmitoyl lysophosphatidic acid. RNA-sequencing analysis identified BPIFB2 as a 
      potential diagnostic biomarker and therapeutic target for AR. Functional 
      enrichment analyses showed that YJD significantly inhibited cytokine secretion 
      pathways in AR model guinea pigs. These findings demonstrate that YJD protects 
      against OVA-induced AR in guinea pigs by suppressing inflammation in the nasal 
      mucosa, restoring Th1/Th2 balance, and improving cellular metabolism.
FAU - Yan, Zhanfeng
AU  - Yan Z
AD  - Department of Otorhinolaryngology, Dongzhimen Hospital, The First Affiliated 
      Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.
FAU - Liu, Lili
AU  - Liu L
AD  - Department of Otorhinolaryngology, Dongzhimen Hospital, The First Affiliated 
      Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.
FAU - Yuan, Jingjing
AU  - Yuan J
AD  - Department of Otorhinolaryngology, Dongzhimen Hospital, The First Affiliated 
      Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.
FAU - Jiao, Lulu
AU  - Jiao L
AD  - Department of Otorhinolaryngology, Dongzhimen Hospital, The First Affiliated 
      Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.
FAU - Zhou, Mo
AU  - Zhou M
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang 
      Hospital, Capital Medical University, Beijing 100000, China.
FAU - Liu, Jinfeng
AU  - Liu J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang 
      Hospital, Capital Medical University, Beijing 100000, China.
FAU - Wen, Xiaohui
AU  - Wen X
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang 
      Hospital, Capital Medical University, Beijing 100000, China.
FAU - Liu, Siming
AU  - Liu S
AD  - Department of Otorhinolaryngology, Dongzhimen Hospital, The First Affiliated 
      Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.
FAU - Hao, Pengpeng
AU  - Hao P
AD  - Department of Otorhinolaryngology, Dongzhimen Hospital, The First Affiliated 
      Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.
FAU - Liu, Jianhua
AU  - Liu J
AD  - Department of Otorhinolaryngology, Dongzhimen Hospital, The First Affiliated 
      Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.
FAU - Wu, Wei
AU  - Wu W
AD  - Department of Otorhinolaryngology, Dongzhimen Hospital, The First Affiliated 
      Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210727
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Biomarkers
MH  - Carrier Proteins/genetics/metabolism
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Eosinophils/metabolism
MH  - Guinea Pigs
MH  - Histamine/metabolism
MH  - Immunoglobulin E/blood
MH  - Mast Cells/metabolism
MH  - Mice
MH  - Nasal Mucosa/drug effects/immunology/metabolism
MH  - Ovalbumin
MH  - Rhinitis, Allergic/chemically induced/genetics/immunology/*prevention & control
MH  - Th1 Cells/*drug effects/immunology/metabolism
MH  - Th1-Th2 Balance/*drug effects
MH  - Th2 Cells/*drug effects/immunology/metabolism
PMC - PMC8351690
OTO - NOTNLM
OT  - Yiqi Jiemin decoction
OT  - allergic rhinitis
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interest.
EDAT- 2021/07/28 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/07/31
CRDT- 2021/07/27 20:30
PHST- 2021/04/26 00:00 [received]
PHST- 2021/06/14 00:00 [accepted]
PHST- 2021/07/28 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/07/27 20:30 [entrez]
PHST- 2021/07/31 00:00 [pmc-release]
AID - 203292 [pii]
AID - 10.18632/aging.203292 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 Jul 27;13(14):18423-18441. doi: 10.18632/aging.203292. 
      Epub 2021 Jul 27.