PMID- 34315495
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20221207
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 20
IP  - 1
DP  - 2021 Jul 27
TI  - High lipoprotein(a) concentrations are associated with lower type 2 diabetes risk 
      in the Chinese Han population: a large retrospective cohort study.
PG  - 76
LID - 10.1186/s12944-021-01504-x [doi]
LID - 76
AB  - BACKGROUND: Lipoprotein (a) [Lp(a)] is a proven independent risk factor for 
      coronary heart disease. It is also associated with type 2 diabetes mellitus 
      (T2DM). However, the correlation between Lp(a) and T2DM has not been clearly 
      elucidated. METHODS: This was a retrospective cohort study involving 9248 T2DM 
      patients and 18,496 control individuals (1:2 matched). Patients were randomly 
      selected from among inpatients in the Second Affiliated Hospital of Nanchang 
      University between 2006 and 2017. Clinical characteristics were compared between 
      the two groups. Spearman rank-order correlation coefficients were used to 
      evaluate the strength and direction of monotonic associations of serum Lp(a) with 
      other metabolic risk factors. Binary logistic regression analysis was used to 
      establish the correlation between Lp(a) levels and T2DM risk. RESULTS: The median 
      Lp(a) concentration was lower in T2DM patients than in controls (16.42 vs. 
      16.88 mg/dL). Based on four quartiles of Lp(a) levels, there was a decrease in 
      T2DM risk from 33.7% (Q1) to 31.96% (Q4) (P for trend < 0.0001). Then, Lp(a) 
      levels > 28.72 mg/dL (Q4) were associated with a significantly lower T2DM risk in 
      the unadjusted model [0.924 (0.861, 0.992), P = 0.030]. Similar results were 
      obtained in adjusted models 1 [Q4, 0.925 (0.862, 0.993), P = 0.031] and 2 [Q4, 
      0.919 (0.854, 0.990), P = 0.026]. Furthermore, in the stratified analysis, Q4 of 
      Lp(a) was associated with a significantly lower T2DM risk among men [0.813 
      (0.734, 0.900), P < 0.001] and those age > 60 years [0.819 (0.737, 0.910), 
      P < 0.001]. In contrast, the low-density lipoprotein cholesterol (LDL-C) levels 
      and coronary heart disease (CHD) did not impact these correlations between Lp(a) 
      and diabetes. CONCLUSIONS: There is an inverse association between Lp(a) levels 
      and T2DM risk in the Chinese population. Male patients, especially those aged 
      more than 60 years with Lp(a) > 28.72 mg/dL, are low-risk T2DM individuals, 
      regardless of LDL-C levels and CHD status.
CI  - (c) 2021. The Author(s).
FAU - Fu, Qingan
AU  - Fu Q
AD  - Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi, China.
FAU - Hu, Lijuan
AU  - Hu L
AD  - Department of Nursing, Science and Technology College of Jiangxi University of 
      Traditional Chinese Medicine, Nanchang, China.
FAU - Xu, Yuan
AU  - Xu Y
AD  - Department of Medical Big Data Center, the Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi, China.
FAU - Yi, Yingping
AU  - Yi Y
AD  - Department of Medical Big Data Center, the Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi, China.
FAU - Jiang, Long
AU  - Jiang L
AUID- ORCID: 0000-0002-1506-7385
AD  - Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi, China. skyiadx@hotmail.com.
LA  - eng
GR  - No. 81700792/National Natural Science Foundation for Young Scientists of China/
GR  - 2018YFC1312902/National Key R&D Program of China/
GR  - No. 2018ACB21035/Natural Science Foundation of Jiangxi Province for Distinguished 
      Young Scholars of China/
GR  - No. 20171BAB215004/Natural Science Foundation of Jiangxi Province (CN)/
GR  - No. PY201821/Nanchang University youth teacher training fund/
GR  - 20193ABC03A043/the 03-special project of jiangxi science and technology 
      department/
PT  - Journal Article
DEP - 20210727
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Lipoprotein(a))
SB  - IM
MH  - Asian People/statistics & numerical data
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Hyperlipoproteinemias/blood/*complications
MH  - Lipoprotein(a)/*blood
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC8317300
COIS- All authors have given permission to submit, and there are no conflicts of 
      interests to report. The Authors declare that there is no conflict of interest.
EDAT- 2021/07/29 06:00
MHDA- 2022/03/29 06:00
PMCR- 2021/07/27
CRDT- 2021/07/28 05:36
PHST- 2021/04/15 00:00 [received]
PHST- 2021/07/15 00:00 [accepted]
PHST- 2021/07/28 05:36 [entrez]
PHST- 2021/07/29 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/07/27 00:00 [pmc-release]
AID - 10.1186/s12944-021-01504-x [pii]
AID - 1504 [pii]
AID - 10.1186/s12944-021-01504-x [doi]
PST - epublish
SO  - Lipids Health Dis. 2021 Jul 27;20(1):76. doi: 10.1186/s12944-021-01504-x.