PMID- 34315734
OWN - NLM
STAT- MEDLINE
DCOM- 20210729
LR  - 20230728
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 14
IP  - 7
DP  - 2021 Jul 27
TI  - Anti-glomerular basement membrane disease and IgA nephropathy in a patient with 
      previous renal cell carcinoma.
LID - 10.1136/bcr-2020-236555 [doi]
LID - e236555
AB  - A 66-year-old Asian woman presented with severe kidney injury, microscopic 
      haematuria and subnephrotic range proteinuria with elevated serum anti-glomerular 
      basement membrane (anti-GBM) titre. She had a history of renal cell carcinoma. 
      Renal biopsy revealed dual pathology with immunofluorescence showing 3+ linear 
      glomerular IgG staining and 3+ IgA mesangial staining. Cellular crescents were 
      present on light microscopy and electron microscopy revealed increased mesangial 
      matrix. She was treated with plasma exchange and immunosuppression and remained 
      in stage 4 chronic kidney disease. This case describes the coexistence of 
      anti-GBM disease and IgA nephropathy, a phenomenon not well described in the 
      literature. The report also explores the association of malignancy and 
      glomerulonephritis as well as the role of genetics and the utility of human 
      leukocyte antigen (HLA) typing in risk stratification.
CI  - (c) BMJ Publishing Group Limited 2021. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Khor, Candice
AU  - Khor C
AD  - Department of Nephrology, Royal North Shore Hospital, Sydney, New South Wales, 
      Australia khor.candice@gmail.com.
FAU - Wong, Muh Geot
AU  - Wong MG
AD  - Department of Nephrology, Royal North Shore Hospital, Sydney, New South Wales, 
      Australia.
AD  - Department of Medicine, Univeristy of Sydney, Sydney, New South Wales, Australia.
FAU - Reagh, Jessica
AU  - Reagh J
AD  - Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, New South 
      Wales, Australia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210727
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Aged
MH  - *Anti-Glomerular Basement Membrane Disease/complications/diagnosis
MH  - Autoantibodies
MH  - *Carcinoma, Renal Cell/complications
MH  - Female
MH  - Glomerular Basement Membrane
MH  - *Glomerulonephritis, IGA/complications/diagnosis
MH  - Humans
MH  - *Kidney Neoplasms/complications
PMC - PMC8319966
OTO - NOTNLM
OT  - acute renal failure
OT  - genetics
OT  - pathology
OT  - proteinurea
OT  - vasculitis
COIS- Competing interests: None declared.
EDAT- 2021/07/29 06:00
MHDA- 2021/07/30 06:00
PMCR- 2023/07/27
CRDT- 2021/07/28 05:45
PHST- 2021/07/28 05:45 [entrez]
PHST- 2021/07/29 06:00 [pubmed]
PHST- 2021/07/30 06:00 [medline]
PHST- 2023/07/27 00:00 [pmc-release]
AID - 14/7/e236555 [pii]
AID - bcr-2020-236555 [pii]
AID - 10.1136/bcr-2020-236555 [doi]
PST - epublish
SO  - BMJ Case Rep. 2021 Jul 27;14(7):e236555. doi: 10.1136/bcr-2020-236555.