PMID- 34315760
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210827
IS  - 2211-4599 (Print)
IS  - 2211-4599 (Electronic)
IS  - 2211-4599 (Linking)
VI  - 15
IP  - 4
DP  - 2021 Aug
TI  - The Influence of Sex on Clinical Outcomes in Minimally Invasive Lumbar 
      Decompression.
PG  - 763-769
LID - 10.14444/8098 [doi]
AB  - BACKGROUND: Research focused on postoperative outcomes among men and women 
      undergoing minimally invasive lumbar decompression (MIS LD) spine surgery is 
      sparse. This study aims to assess the influence of sex on postoperative 
      patient-reported outcome measure (PROM) evaluations and achievement of a minimum 
      clinically important difference (MCID). METHODS: A prospectively maintained 
      surgical database was retrospectively queried for patients undergoing primary or 
      revision, single or multilevel LD procedures from 2011 to 2019. Patients with 
      incomplete visual analog scale (VAS) leg or back surveys were excluded. 
      Demographic and operative variables were recorded, and a chi-squared analysis or 
      t tests were used to compare by sex. PROMs were evaluated from preoperative to 
      postoperative time points. PROM score differences and postoperative improvement 
      were evaluated between sexes by a t test. Achievement of MCID by sex was compared 
      using chi-squared analysis. RESULTS: The study cohort (n = 572) was 70% male (n = 
      398), had an average age of 47 years, and 42% were obese. Sexes differed in 
      preoperative VAS leg, Oswestry Disability Index (ODI), and 12-item short form 
      (SF-12)-physical composite score (PCS) scores (all P < .05) and in ODI at 6 and 
      12 weeks (P = .048; P = .001) and VAS back and leg scores at 6 months (P = .039; 
      P = .019). Both sexes significantly improved (P < .050) all PROMs at all time 
      points except for VAS back at 1 year for women and ODI at 6 weeks and 6 months 
      for men. The only significant difference in achievement of MCID was for ODI at 6 
      months (P = .008). CONCLUSIONS: Significant preoperative differences were 
      observed among sexes with ODI, SF-12-PCS, and VAS leg scores. By 1 year, there 
      were no significant sex differences for any PROM or for achievement of MCID. MIS 
      LD has an equivalent role for both sexes in achieving MCID. LEVEL OF EVIDENCE: 3. 
      CLINICAL RELEVANCE: Results demonstrate no sex difference in PROMs following LD.
CI  - This manuscript is generously published free of charge by ISASS, the 
      International Society for the Advancement of Spine Surgery. Copyright (c) 2021 
      ISASS.
FAU - Nolte, Michael T
AU  - Nolte MT
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, 
      Illinois.
FAU - Jenkins, Nathaniel W
AU  - Jenkins NW
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, 
      Illinois.
FAU - Parrish, James M
AU  - Parrish JM
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, 
      Illinois.
FAU - Mohan, Shruthi
AU  - Mohan S
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, 
      Illinois.
FAU - Geoghegan, Cara E
AU  - Geoghegan CE
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, 
      Illinois.
FAU - Jadczak, Caroline N
AU  - Jadczak CN
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, 
      Illinois.
FAU - Hrynewycz, Nadia M
AU  - Hrynewycz NM
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, 
      Illinois.
FAU - Singh, Kern
AU  - Singh K
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, 
      Illinois.
LA  - eng
PT  - Journal Article
DEP - 20210727
PL  - Netherlands
TA  - Int J Spine Surg
JT  - International journal of spine surgery
JID - 101579005
PMC - PMC8375674
OTO - NOTNLM
OT  - LD
OT  - MCID
OT  - lumbar decompression
OT  - minimum clinically important difference
OT  - sex
COIS- Disclosures and COI: None.
EDAT- 2021/07/29 06:00
MHDA- 2021/07/29 06:01
PMCR- 2021/08/19
CRDT- 2021/07/28 05:45
PHST- 2021/07/29 06:00 [pubmed]
PHST- 2021/07/29 06:01 [medline]
PHST- 2021/07/28 05:45 [entrez]
PHST- 2021/08/19 00:00 [pmc-release]
AID - 8098 [pii]
AID - 10.14444/8098 [doi]
PST - ppublish
SO  - Int J Spine Surg. 2021 Aug;15(4):763-769. doi: 10.14444/8098. Epub 2021 Jul 27.