PMID- 34318377
OWN - NLM
STAT- MEDLINE
DCOM- 20220103
LR  - 20220103
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 188
IP  - 8
DP  - 2021 Jul 27
TI  - Simultaneous trace-level monitoring of seven opioid analgesic drugs in biological 
      samples by pipette-tip micro solid phase extraction based on PVA-PAA/CNT-CNC 
      composite nanofibers followed by  HPLC-UV analysis.
PG  - 275
LID - 10.1007/s00604-021-04931-w [doi]
AB  - Electrospun poly(vinyl alcohol)-(PVA)-poly(acrylic acid) (PAA)/carbon 
      nanotubes(CNTs)-cellulose nanocrystal (CNC) (PVA-PAA/CNT-CNC) composite 
      nanofibers were prepared and characterized using Fourier transform-infrared 
      spectroscopy and field emission scanning electron microscopy. The resultant 
      composite was used as an effective and novel sorbent for pipette-tip micro-solid 
      phase extraction (PT-muSPE) of seven opioid analgesics (OAs) in biological samples 
      followed by HPLC-UV analysis. Addition of CNT-CNC with the high specific surface 
      area and plenty of OH-functional groups endows the nanofibers with considerable 
      extraction efficiency. Under the optimum conditions, the linearity was obtained 
      in the range 1.5 to 700.0 ng mL(-1) for morphine, codeine, oxycodone, and 
      tramadol, and 0.5 to 1000.0 ng mL(-1) for nalbuphine, thebaine, and noscapine 
      with coefficient of determination (r(2)) >/= 0.9990. Detection limits (LODs) based 
      on S/N = 3 were in the range of 0.15-0.50 ng mL(-1). The relative standard 
      deviations (RSDs) of 4.1-5.4% (intra-day, n = 5) and 5.2-6.4% (inter-day, n = 3) 
      for three consecutive days were achieved. Finally, the efficiency of the 
      PT-muSPE-HPLC-UV method was evaluated for the determination of OAs in human plasma 
      and urine samples with good recoveries (87.3 to 97.8%). A: Schematic illustration 
      for the preparation of PVA-PAA/CNT-CNC composite nanofibers. B: Schematic 
      presentation of applying PVA-PAA/CNT-CNC composite nanofibers as the sorbent in 
      pipette-tip micro solid-phase extraction (PT-muSPE) for the preconcentration of 
      seven opioid analgesic drugs in biological samples before HPLC-UV analysis.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, 
      part of Springer Nature.
FAU - Hejabri Kandeh, Saeed
AU  - Hejabri Kandeh S
AD  - Department of Analytical Chemistry and Pollutants, Faculty of Chemistry and 
      Petroleum Sciences, Shahid Beheshti University, Tehran, Iran.
FAU - Amini, Shima
AU  - Amini S
AD  - Department of Analytical Chemistry and Pollutants, Faculty of Chemistry and 
      Petroleum Sciences, Shahid Beheshti University, Tehran, Iran.
FAU - Ebrahimzadeh, Homeira
AU  - Ebrahimzadeh H
AUID- ORCID: 0000-0002-9137-8740
AD  - Department of Analytical Chemistry and Pollutants, Faculty of Chemistry and 
      Petroleum Sciences, Shahid Beheshti University, Tehran, Iran. 
      h-ebrahim@sbu.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20210727
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
RN  - 0 (Acrylic Resins)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Nanotubes, Carbon)
RN  - 4Q93RCW27E (carbopol 940)
RN  - 9002-89-5 (Polyvinyl Alcohol)
RN  - 9004-34-6 (Cellulose)
SB  - IM
MH  - Acrylic Resins/chemistry
MH  - Adsorption
MH  - Analgesics, Opioid/blood/chemistry/*isolation & purification/urine
MH  - Cellulose/chemistry
MH  - Chromatography, High Pressure Liquid
MH  - Humans
MH  - Limit of Detection
MH  - Nanocomposites/*chemistry
MH  - Nanofibers/*chemistry
MH  - Nanoparticles/chemistry
MH  - Nanotubes, Carbon/chemistry
MH  - Polyvinyl Alcohol/chemistry
MH  - Solid Phase Microextraction/instrumentation/*methods
MH  - Spectrophotometry, Ultraviolet
OTO - NOTNLM
OT  - Biological samples
OT  - Composite nanofibers
OT  - Electrospinning
OT  - Opioid analgesic drugs
OT  - Pipette-tip solid-phase extraction
OT  - Sample pretreatment
EDAT- 2021/07/29 06:00
MHDA- 2022/01/04 06:00
CRDT- 2021/07/28 06:46
PHST- 2021/05/03 00:00 [received]
PHST- 2021/07/06 00:00 [accepted]
PHST- 2021/07/28 06:46 [entrez]
PHST- 2021/07/29 06:00 [pubmed]
PHST- 2022/01/04 06:00 [medline]
AID - 10.1007/s00604-021-04931-w [pii]
AID - 10.1007/s00604-021-04931-w [doi]
PST - epublish
SO  - Mikrochim Acta. 2021 Jul 27;188(8):275. doi: 10.1007/s00604-021-04931-w.