PMID- 34320128
OWN - NLM
STAT- MEDLINE
DCOM- 20210730
LR  - 20230920
IS  - 1678-9849 (Electronic)
IS  - 0037-8682 (Print)
IS  - 0037-8682 (Linking)
VI  - 54
DP  - 2021
TI  - Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis 
      burden: a systematic review and meta-analysis.
PG  - e00172021
LID - S0037-86822021000100328 [pii]
LID - 10.1590/0037-8682-0017-2021 [doi]
LID - e0017-2021
AB  - INTRODUCTION: Tuberculosis (TB) is the leading cause of death worldwide caused by 
      a single infectious disease agent. Brazil, Russia, India, China, and South Africa 
      (BRICS) account for more than half of the world's TB cases. Bacillus 
      Calmette-Guerin (BCG) remains the only vaccine available despite its variable 
      efficacy. Promising antigen-based vaccines have been proposed as prophylactic 
      and/or immunotherapeutic approaches to boost BCG vaccination. Relevant antigens 
      must interact with the range of human leukocyte antigen (HLA) molecules present 
      in target populations; yet this information is currently not available. METHODS: 
      MEDLINE and EMBASE were systematically searched for articles published during 
      2013-2020 to measure the allelic frequencies of HLA-DRB1 in the BRICS. RESULTS: 
      In total, 67 articles involving 3,207,861 healthy individuals were included in 
      the meta-analysis. HLA-DRB1 alleles *03, *04, *07, *11, *13, and *15 were 
      consistently identified at high frequencies across the BRICS, with a combined 
      estimated frequency varying from 52% to 80%. HLA-DRB1 alleles *01, *08, *09, *10, 
      *12, and *14 were found to be relevant in only one or two BRICS populations. 
      CONCLUSIONS: By combining these alleles, it is possible to ensure at least 80% 
      coverage throughout the BRICS populations.
FAU - Sarno, Alice
AU  - Sarno A
AUID- ORCID: 0000-0001-7440-695X
AD  - Fundacao Oswaldo Cruz, Instituto Goncalo Moniz, Salvador, BA, Brasil.
FAU - Daltro, Cleidiane Borges
AU  - Daltro CB
AUID- ORCID: 0000-0001-8395-2768
AD  - Fundacao Oswaldo Cruz, Instituto Goncalo Moniz, Salvador, BA, Brasil.
FAU - Mendes, Carlos Mauricio Cardeal
AU  - Mendes CMC
AUID- ORCID: 0000-0003-2089-5668
AD  - Universidade Federal da Bahia, Instituto de Ciencias da Saude, Salvador, BA, 
      Brasil.
FAU - Barbosa, Theolis
AU  - Barbosa T
AUID- ORCID: 0000-0003-1928-0404
AD  - Fundacao Oswaldo Cruz, Instituto Goncalo Moniz, Salvador, BA, Brasil.
AD  - Rede Brasileira de Pesquisas em Tuberculose, Rio de Janeiro, RJ, Brasil.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210723
PL  - Brazil
TA  - Rev Soc Bras Med Trop
JT  - Revista da Sociedade Brasileira de Medicina Tropical
JID - 7507456
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Brazil
MH  - China
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - India
MH  - Russia
MH  - South Africa
MH  - *Tuberculosis
PMC - PMC8313104
COIS- Conflict of interest: The funders had no role in the study design, data 
      collection and analysis, decision to publish, or preparation of the manuscript. 
      None of the authors has any potential financial conflict of interest related to 
      this manuscript.
EDAT- 2021/07/29 06:00
MHDA- 2021/07/31 06:00
PMCR- 2021/07/23
CRDT- 2021/07/28 17:25
PHST- 2021/02/04 00:00 [received]
PHST- 2021/05/21 00:00 [accepted]
PHST- 2021/07/28 17:25 [entrez]
PHST- 2021/07/29 06:00 [pubmed]
PHST- 2021/07/31 06:00 [medline]
PHST- 2021/07/23 00:00 [pmc-release]
AID - S0037-86822021000100328 [pii]
AID - 10.1590/0037-8682-0017-2021 [doi]
PST - epublish
SO  - Rev Soc Bras Med Trop. 2021 Jul 23;54:e00172021. doi: 
      10.1590/0037-8682-0017-2021. eCollection 2021.