PMID- 34320386
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220113
IS  - 1878-5492 (Electronic)
IS  - 0966-3274 (Linking)
VI  - 68
DP  - 2021 Oct
TI  - Sulforaphane alleviates hepatic ischemia-reperfusion injury through promoting the 
      activation of Nrf-2/HO-1 signaling.
PG  - 101439
LID - S0966-3274(21)00079-4 [pii]
LID - 10.1016/j.trim.2021.101439 [doi]
AB  - BACKGROUND: Sulforaphane (SFN)displays both anti-oxidative stress and 
      anti-inflammatory activity. Given that inflammation and oxidative stress play 
      important roles in hepatic ischemia-reperfusion injury (HI/RI), we examined the 
      protective effect and potential mechanism of SFN on HI/RI. METHODS: The maneuver 
      of Pringle's was used to establish the mode of HI/RI and 60 SD rats were randomly 
      divided into Sham, HI/RI, SFN and ML385 Groups. The expression of 
      aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase 
      (ALP), Nuclear factor-E2-related factor 2(Nrf-2), heme oxygenase 1(HO-1), nitric 
      oxide (NO), Cyclooxygenase2 (COX-2), NADPH quinone oxidoreductase 1 (NQO1), 
      malondialdehyde (MDA), tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) and 
      monocyte chemotactic protein 1(MCP-1) were measured. Moreover, hepatic 
      pathological morphology and the activity of glutathione (GSH), Catalase (CAT), 
      superoxide dismutase (SOD) of the liver were also examined. RESULTS: SFN 
      treatment can significantly decrease the hepatic pathological injury and 
      down-regulate the expression of ALT, AST, ALP, COX-2, TNF-a, IL-6, MCP-1, NO and 
      MDA in HI/RI with increasing the expression of Nrf2, NQO1 and HO-1, and 
      up-regulating the activity of GSH, CAT and SOD. Moreover, Nrf-2 inhibitor, ML385 
      can obliviously reverse the protective effect of SFN on HI/RI. CONCLUSION: 
      Sulforaphane can inhibit the inflammatory response and oxidative stress induced 
      by HI/RI through promoting the activation of the Nrf-2 / HO-1 signal pathway.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Chen, Li
AU  - Chen L
AD  - Department of Gastroenterology, Anyue Country People's Hospital, Ziyang, China.
FAU - Zhang, Wen-Li
AU  - Zhang WL
AD  - Department of Gastroenterology, Changning Hospital of Traditional Chinese 
      Medicine, Yibin 644000, China.
FAU - Xie, De-Qiong
AU  - Xie DQ
AD  - Division of Nephrology, The Second People's Hospital of Yibin, Yibin 644000, 
      China. Electronic address: 1285396756@qq.com.
FAU - Jia, Wang
AU  - Jia W
AD  - General Practice Center, and University of Electronic Science and Technology, 
      Sichuan Academy of Sciences & Sichuan Provincial People's Hospital, Chengdu 
      610072, China. Electronic address: 1329762092@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210725
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (Isothiocyanates)
RN  - 0 (Sulfoxides)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - GA49J4310U (sulforaphane)
SB  - IM
MH  - Animals
MH  - *Heme Oxygenase-1/metabolism
MH  - Isothiocyanates
MH  - Liver/metabolism
MH  - Oxidative Stress
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Reperfusion Injury/drug therapy/metabolism
MH  - Signal Transduction
MH  - Sulfoxides
OTO - NOTNLM
OT  - Hepatic ischemia-reperfusion injury
OT  - Inflammation
OT  - Nrf-2/HO-1
OT  - Oxidative stress
OT  - Sulforaphane
EDAT- 2021/07/29 06:00
MHDA- 2022/01/14 06:00
CRDT- 2021/07/28 20:07
PHST- 2021/04/01 00:00 [received]
PHST- 2021/07/19 00:00 [revised]
PHST- 2021/07/22 00:00 [accepted]
PHST- 2021/07/29 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
PHST- 2021/07/28 20:07 [entrez]
AID - S0966-3274(21)00079-4 [pii]
AID - 10.1016/j.trim.2021.101439 [doi]
PST - ppublish
SO  - Transpl Immunol. 2021 Oct;68:101439. doi: 10.1016/j.trim.2021.101439. Epub 2021 
      Jul 25.