PMID- 34320485
OWN - NLM
STAT- MEDLINE
DCOM- 20210915
LR  - 20210915
IS  - 1741-2552 (Electronic)
IS  - 1741-2552 (Linking)
VI  - 18
IP  - 4
DP  - 2021 Aug 25
TI  - Stroke-induced alteration in multi-layer information transmission of 
      cortico-motor system during elbow isometric contraction modulated by 
      myoelectric-controlled interfaces.
LID - 10.1088/1741-2552/ac18ae [doi]
AB  - Objective. Human movement is a complex process requiring information transmission 
      in inter-cortical, cortico-muscular and inter-muscular networks. Though motor 
      deficits after stroke are associated with impaired networks in the cortico-motor 
      system, the mechanisms underlying these networks are to date not fully 
      understood. The purpose of this study is to investigate the changes in 
      information transmission of the inter-cortical, cortico-muscular and 
      inter-muscular networks after stroke and the effect of myoelectric-controlled 
      interface (MCI) dimensionality on such information transmission in each 
      network.Approach. Fifteen healthy control subjects and 11 post-stroke patients 
      were recruited to perform elbow tracking tasks within different dimensional MCIs 
      in this study. Their electromyography (EMG) and functional near-infrared 
      spectroscopy (fNIRS) signals were recorded simultaneously. Transfer entropy was 
      used to analyse the functional connection that represented the information 
      transmission in each network based on the fNIRS and EMG signals.Main results.The 
      results found that post-stroke patients showed the increased inter-cortical 
      connection versus healthy control subjects, which might be attributed to cortical 
      reorganisation to compensate for motor deficits. Compared to healthy control 
      subjects, a lower strength cortico-muscular connection was found in post-stroke 
      patients due to the reduction of information transmission following a stroke. 
      Moreover, the increased MCI dimensionality strengthened inter-cortical, 
      cortico-muscular and inter-muscular connections because of higher visual 
      information processing demands.Significance. These findings not only provide a 
      comprehensive overview to evaluate changes in the cortico-motor system due to 
      stroke, but also suggest that increased MCI dimensionality may serve as a useful 
      rehabilitation tool for boosting information transmission in the cortico-motor 
      system of post-stroke patients.
CI  - (c) 2021 IOP Publishing Ltd.
FAU - Jian, Chuyao
AU  - Jian C
AD  - Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong 
      Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 
      510275, People's Republic of China.
AD  - Shenzhen Research Institute of Sun Yat-sen University, Shenzhen 518057, People's 
      Republic of China.
FAU - Liu, Huihua
AU  - Liu H
AD  - Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, People's 
      Republic of China.
FAU - Deng, Linchuan
AU  - Deng L
AD  - Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong 
      Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 
      510275, People's Republic of China.
AD  - Shenzhen Research Institute of Sun Yat-sen University, Shenzhen 518057, People's 
      Republic of China.
FAU - Wang, Xiaoyun
AU  - Wang X
AD  - Guangdong Work Injury Rehabilitation Center, Guangzhou 510440, People's Republic 
      of China.
FAU - Yan, Tiebin
AU  - Yan T
AD  - Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, People's 
      Republic of China.
FAU - Song, Rong
AU  - Song R
AUID- ORCID: 0000-0003-3662-116X
AD  - Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong 
      Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 
      510275, People's Republic of China.
AD  - Shenzhen Research Institute of Sun Yat-sen University, Shenzhen 518057, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210825
PL  - England
TA  - J Neural Eng
JT  - Journal of neural engineering
JID - 101217933
SB  - IM
MH  - Elbow
MH  - Electromyography
MH  - Humans
MH  - *Isometric Contraction
MH  - Movement
MH  - Muscle, Skeletal
MH  - *Stroke/complications
OTO - NOTNLM
OT  - cortico-motor system
OT  - motor control
OT  - stroke
OT  - transfer entropy
OT  - visual dimension
EDAT- 2021/07/29 06:00
MHDA- 2021/09/16 06:00
CRDT- 2021/07/28 20:12
PHST- 2021/05/12 00:00 [received]
PHST- 2021/07/28 00:00 [accepted]
PHST- 2021/07/29 06:00 [pubmed]
PHST- 2021/09/16 06:00 [medline]
PHST- 2021/07/28 20:12 [entrez]
AID - 10.1088/1741-2552/ac18ae [doi]
PST - epublish
SO  - J Neural Eng. 2021 Aug 25;18(4). doi: 10.1088/1741-2552/ac18ae.