PMID- 34320936
OWN - NLM
STAT- MEDLINE
DCOM- 20210730
LR  - 20210801
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Jul 29
TI  - Swept-source optical coherence tomography changes and visual acuity among 
      Palestinian retinitis Pigmentosa patients: a cross-sectional study.
PG  - 289
LID - 10.1186/s12886-021-02047-6 [doi]
LID - 289
AB  - BACKGROUND: Retinitis pigmentosa (RP) is a heterogeneous group of inherited 
      ocular diseases that result in progressive retinal degeneration. This study aims 
      to describe different Swept-source Optical Coherence Tomographic (SS-OCT) changes 
      in Palestinian RP patients and to explore possible correlations with Visual 
      Acuity (VA). METHODS: A cross-sectional observational study was conducted on 
      Retinitis Pigmentosa patients diagnosed with RP in a tertiary eye hospital. Full 
      history and ocular examination were made. SS-OCT imaging was done for all eyes 
      assessing the presence of cystoid macular edema, epiretinal membrane, macular 
      holes, and external limiting membrane, ellipsoid zone status. Also, central 
      macular thickness and choroidal vascular thickness were measured. RESULTS: The 
      study was run on 161 eyes of 81 patients; 53 males and 28 females. The average 
      age at examination was 26.1 (6-78) years. Twenty-six eyes (16.1%) were of 
      syndromic RP patients, mostly Usher syndrome; 20 eyes (12.4%). The mean 
      Logaritmic minimal angle of resolution (LogMAR) of Best Corrected Visual Acuity 
      (BCVA)of the study sample was 0.66 +/- 0.7. The most prevalent change was cystoid 
      macular edema [28 eyes, (17.4%)], followed by epiretinal membrane [17eye, 
      (10.6%)]. A macular hole was noted only in one eye (0.6%). Ellipsoid zone and 
      external limiting membrane were absent in 55 eyes (35.0%) and 60 eyes 37.5%. 
      Vitreous hyperreflective foci were found in 35 eyes (43.8%). LogMAR of BCVA was 
      associated significantly with cystoid macular edema (p = 0.001), ellipsoid 
      zone(p = 0.001), and external limiting membrane (p = 0.001). CONCLUSIONS: 
      Detailed SS-OCT assessment in Palestinian patients diagnosed with RP identified 
      different morphologies from other populations. Cystoid macular edema and vitreous 
      hyperreflective foci may reflect signs of early or intermediate stages of the 
      disease. Disease progression can be monitored by measuring the length/width 
      (area) of ellipsoid zone +/- external limiting membrane and choroidal vascular 
      thickness, which should be evaluated serially using high-resolution OCT.
CI  - (c) 2021. The Author(s).
FAU - Shalabi, Orjowan
AU  - Shalabi O
AD  - St. John of Jerusalem Eye Hospital Group, East Jerusalem, 91198, Palestine.
FAU - Nazzal, Zaher
AU  - Nazzal Z
AD  - Department of Family and Community Medicine, Faculty of Medicine and Health 
      Sciences, An-Najah National University, Nablus, Palestine.
FAU - Natsheh, Muath
AU  - Natsheh M
AD  - St. John of Jerusalem Eye Hospital Group, East Jerusalem, 91198, Palestine.
FAU - Iriqat, Salam
AU  - Iriqat S
AD  - St. John of Jerusalem Eye Hospital Group, East Jerusalem, 91198, Palestine.
FAU - Michaelides, Michel
AU  - Michaelides M
AD  - Department of genetics, Moorfields Eye Hospital and UCL Institute of 
      Ophthalmology, London, UK.
FAU - Ghanem, Muyassar
AU  - Ghanem M
AD  - St. John of Jerusalem Eye Hospital Group, East Jerusalem, 91198, Palestine.
FAU - Aslanian, Alice
AU  - Aslanian A
AD  - St. John of Jerusalem Eye Hospital Group, East Jerusalem, 91198, Palestine.
FAU - Alswaiti, Yahya
AU  - Alswaiti Y
AD  - St. John of Jerusalem Eye Hospital Group, East Jerusalem, 91198, Palestine.
FAU - AlTalbishi, Alaa
AU  - AlTalbishi A
AD  - St. John of Jerusalem Eye Hospital Group, East Jerusalem, 91198, Palestine. 
      Dralaa83@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210729
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Arabs
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Retina
MH  - *Retinitis Pigmentosa/diagnosis
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity
PMC - PMC8320214
OTO - NOTNLM
OT  - Cystoid macular edema
OT  - Ellipsoid zone
OT  - Retinitis Pigmentosa, SS-OCT
OT  - Visual acuity
COIS- "The authors declare that they have no competing interests" in this section.
EDAT- 2021/07/30 06:00
MHDA- 2021/07/31 06:00
PMCR- 2021/07/29
CRDT- 2021/07/29 05:33
PHST- 2020/11/13 00:00 [received]
PHST- 2021/07/09 00:00 [accepted]
PHST- 2021/07/29 05:33 [entrez]
PHST- 2021/07/30 06:00 [pubmed]
PHST- 2021/07/31 06:00 [medline]
PHST- 2021/07/29 00:00 [pmc-release]
AID - 10.1186/s12886-021-02047-6 [pii]
AID - 2047 [pii]
AID - 10.1186/s12886-021-02047-6 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2021 Jul 29;21(1):289. doi: 10.1186/s12886-021-02047-6.