PMID- 34321157
OWN - NLM
STAT- MEDLINE
DCOM- 20210812
LR  - 20210812
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 130
DP  - 2020 Oct
TI  - Magnesium lithospermate B ameliorates hypobaric hypoxia-induced pulmonary 
      arterial hypertension by inhibiting endothelial-to-mesenchymal transition and its 
      potential targets.
PG  - 110560
LID - S0753-3322(20)30753-8 [pii]
LID - 10.1016/j.biopha.2020.110560 [doi]
AB  - Pulmonary arterial hypertension (PAH) is a progressive disease characterized by 
      vascular remodeling leading to elevation of pulmonary artery pressure, right 
      ventricular hypertrophy, and death. Currently, there are no cure exists for PAH. 
      Magnesium lithospermate B (MLB) is the major component of Salvia przewalskii 
      water extracts with treating angina and cardiovascular damage, anti-inflammation, 
      anti-oxidation and anti-apoptosis. However, the effects of MLB on PAH still 
      unclear. This study we investigated the efficacy of MLB in the hypobaric 
      hypoxia-induced rat model of PAH. The results showed that MLB relieved mean 
      pulmonary arterial pressure (mPAP) and right ventricular hypertrophy index 
      (RVHI). Meanwhile, MLB significantly reduced pulmonary vascular remodeling. 
      Additionally, MLB inhibited hypobaric hypoxia-induced alpha-smooth muscle actin 
      (alpha-SMA) expression, cell apoptosis, and alpha-SMA and von Willebrand factor (vWF) 
      co-expression in lung, suggesting that MLB could inhibit hypobaric 
      hypoxia-induced endothelial-to-mesenchymal transition (EndMT). Furthermore, after 
      treatment with MLB, the expression of hypoxia inducible factor-1alpha (HIF-1alpha), 
      nuclear factor-kappa B (NF-kappaB), monocyte chemoattractant protein-1 (MCP-1), 
      proliferating cell nuclear antigen (PCNA), cyclin-dependent kinase 4 (CDK4), 
      CyclinD1, RhoA, rho-associated protein kinase 1 (ROCK1) and ROCK2 was decreased. 
      Further, CHK1, PIM1, STK6, LKHA4, PDE5A, BRAF1, PLK1, AKT1, PAK6, PAK7 and ELNE 
      may be the potential targets of MLB. Taken together, our findings suggest that 
      MLB ameliorates hypobaric hypoxia-induced PAH by inhibiting EndMT in rats, and 
      has potential value in the preventment and treatment of PAH.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Wang, Yafeng
AU  - Wang Y
AD  - The First Hospital of Lanzhou University, Lanzhou 730000, China; Qinghai 
      Provincial People's Hospital，Xining 810007,China. Electronic address: 
      gyyxgzz@outlook.com.
FAU - Duo, Delong
AU  - Duo D
AD  - Qinghai Provincial People's Hospital，Xining 810007,China.
FAU - Yan, Yingjun
AU  - Yan Y
AD  - Qinghai Provincial People's Hospital，Xining 810007,China.
FAU - He, Rongyue
AU  - He R
AD  - Qinghai Provincial People's Hospital，Xining 810007,China.
FAU - Wu, Xinan
AU  - Wu X
AD  - The First Hospital of Lanzhou University, Lanzhou 730000, China. Electronic 
      address: xinanwu6511@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200812
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Biomarkers)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 122021-74-3 (lithospermate B)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Disease Management
MH  - Disease Models, Animal
MH  - Disease Susceptibility
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Endothelium, Vascular/*drug effects/*metabolism/pathology
MH  - Gene Expression
MH  - Hypertension, Pulmonary/diagnosis/drug therapy/*etiology/*metabolism
MH  - Hypertrophy, Right Ventricular/etiology/metabolism/pathology
MH  - Hypoxia/*complications
MH  - Rats
MH  - Signal Transduction
OTO - NOTNLM
OT  - Endothelial-to-mesenchymal transition
OT  - Hypoxia
OT  - Magnesium lithospermate B
OT  - Potential targets
OT  - Pulmonary arterial hypertension
EDAT- 2021/07/30 06:00
MHDA- 2021/08/13 06:00
CRDT- 2021/07/29 05:44
PHST- 2020/04/21 00:00 [received]
PHST- 2020/07/22 00:00 [revised]
PHST- 2020/07/25 00:00 [accepted]
PHST- 2021/07/29 05:44 [entrez]
PHST- 2021/07/30 06:00 [pubmed]
PHST- 2021/08/13 06:00 [medline]
AID - S0753-3322(20)30753-8 [pii]
AID - 10.1016/j.biopha.2020.110560 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2020 Oct;130:110560. doi: 10.1016/j.biopha.2020.110560. Epub 
      2020 Aug 12.