PMID- 34323845
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231222
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 789
DP  - 2021 Oct 1
TI  - Joint association of prenatal bisphenol-A and phthalates exposure with risk of 
      atopic dermatitis in 6-month-old infants.
PG  - 147953
LID - S0048-9697(21)03024-2 [pii]
LID - 10.1016/j.scitotenv.2021.147953 [doi]
AB  - BACKGROUND: Prenatal exposure to bisphenol A (BPA) and phthalates could trigger 
      immune response. Few studies have investigated the association between prenatal 
      BPA and phthalate exposure and atopic dermatitis (AD) in infants. OBJECTIVE: We 
      aimed to clarify the joint association of prenatal exposure to BPA and phthalate 
      metabolites with AD incidence in 6-month-old infants. METHODS: We included 413 
      mother-child pairs from the Mothers and Children's Environmental Health (MOCEH) 
      in a prospective birth cohort study. Maternal urinary BPA, 
      mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate 
      (MEOHP), and mono-n-butyl phthalate (MnBP) concentrations were measured during 
      early and late pregnancy. We applied the Bayesian kernel machine regression 
      (BKMR) with probit regression to estimate the association of BPA and phthalate 
      metabolites with AD incidence after adjusting for potential confounders. 
      Individual association was estimated by differences in predicted probabilities 
      comparing each individual chemical concentration at 75th versus 25th percentiles, 
      while other chemicals were set at their median. Overall joint effect was 
      estimated by differences in predicted probabilities comparing all chemical 
      concentrations at 75th versus 25th percentiles. RESULTS: Individual effect of 
      MEHHP in late pregnancy was strongly associated with incident AD [Difference: 
      0.244 (95% credible interval: -0.066, 0.554)] in the model including both early 
      and late exposures. Furthermore, we confirmed overall joint association of 
      urinary BPA and phthalate metabolites during pregnancy with a higher risk of AD 
      [0.347 (0.168, 0.526) for late pregnancy exposure, and 0.307 (0.094, 0.521) for 
      both early and late pregnancy]. Additionally, the joint association was more 
      prominent among girls than that in boys. CONCLUSIONS: The joint association of 
      prenatal exposure to BPA and phthalates could be associated with the incident AD 
      in 6-month-old infants. Further studies are needed to confirm the synergistic 
      effect of BPA and phthalate exposures on AD in children.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Lee, Seulbi
AU  - Lee S
AD  - Department of Occupational and Environmental Medicine, College of Medicine, Ewha 
      Womans University, Seoul, Republic of Korea; Department of Epidemiology, School 
      of Public Health, University of Michigan, Ann Arbor, MI, United States.
FAU - Park, Sung Kyun
AU  - Park SK
AD  - Department of Epidemiology, School of Public Health, University of Michigan, Ann 
      Arbor, MI, United States; Department of Environmental Health Sciences, School of 
      Public Health, University of Michigan, Ann Arbor, MI, United States.
FAU - Park, Hyesook
AU  - Park H
AD  - Department of Preventive Medicine, College of Medicine, Ewha Womans University, 
      Seoul, Republic of Korea; Graduate Program in System Health Science and 
      Engineering, Ewha Womans University, Seoul, Republic of Korea.
FAU - Lee, Woojoo
AU  - Lee W
AD  - Department of Public Health Sciences, Graduate School of Public Health, Seoul 
      National University, Seoul, Republic of Korea.
FAU - Lee, Ji Hyen
AU  - Lee JH
AD  - Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Hong, Yun-Chul
AU  - Hong YC
AD  - Department of Preventive Medicine, College of Medicine, Seoul National 
      University, Seoul, Republic of Korea.
FAU - Ha, Mina
AU  - Ha M
AD  - Department of Preventive Medicine, College of Medicine, Dankook University, 
      Cheonan, Republic of Korea.
FAU - Kim, Yangho
AU  - Kim Y
AD  - Department of Occupational and Environmental Medicine, Ulsan University Hospital, 
      University of Ulsan College of Medicine, Ulsan, Republic of Korea.
FAU - Lee, Bo-Eun
AU  - Lee BE
AD  - Environmental Health Research Division, National Institute of Environmental 
      Research, Incheon, Republic of Korea.
FAU - Ha, Eunhee
AU  - Ha E
AD  - Department of Occupational and Environmental Medicine, College of Medicine, Ewha 
      Womans University, Seoul, Republic of Korea; Graduate Program in System Health 
      Science and Engineering, Ewha Womans University, Seoul, Republic of Korea; Ewha 
      Medical Research Institute, College of Medicine, Ewha Womans University, Seoul, 
      Republic of Korea. Electronic address: Eunheeha@ewha.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20210524
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
SB  - IM
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Bayesian kernel machine regression model
OT  - Bisphenol A
OT  - Multi-pollutant effect
OT  - Phthalates
OT  - Prenatal exposure
OT  - Prospective birth cohort
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/07/30 06:00
MHDA- 2021/07/30 06:01
CRDT- 2021/07/29 12:21
PHST- 2020/12/01 00:00 [received]
PHST- 2021/05/16 00:00 [revised]
PHST- 2021/05/17 00:00 [accepted]
PHST- 2021/07/30 06:01 [medline]
PHST- 2021/07/30 06:00 [pubmed]
PHST- 2021/07/29 12:21 [entrez]
AID - S0048-9697(21)03024-2 [pii]
AID - 10.1016/j.scitotenv.2021.147953 [doi]
PST - ppublish
SO  - Sci Total Environ. 2021 Oct 1;789:147953. doi: 10.1016/j.scitotenv.2021.147953. 
      Epub 2021 May 24.