PMID- 34324162
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20220315
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 45
IP  - 2
DP  - 2022 Feb
TI  - The relationship between serum 25-hydroxyvitamin-D level and sweat function in 
      patients with type 2 diabetes mellitus.
PG  - 361-368
LID - 10.1007/s40618-021-01651-z [doi]
AB  - AIMS: The objective of this study is to explore the relationship between serum 
      25-hydroxyvitamin-D(25-(OH)(2)D(3)) level and sweat function in patients with 
      type 2 diabetes mellitus (T2DM). METHODS: A cross-sectional study of 1021 
      patients with T2DM who underwent 25-(OH)(2)D(3) level detections and sweat 
      function tests was carried out. These individuals were divided into deficient 
      groups (n = 154 cases), insufficient groups (n = 593 cases) and sufficient groups 
      (n = 274 cases). Spearman correlation analysis and multivariate stepwise linear 
      regression analysis were implemented to determine the association of 25-(OH)2D3 
      level and sweat function. RESULTS: The total presence of sweating dysfunction was 
      38.59%. Patients with a lower level of serum 25-(OH)(2)D(3) had more severe sweat 
      secretion impairment (P < 0.05). As the decrease of serum 25-(OH)(2)D(3) level, 
      the presence of sweating dysfunction increased (P < 0.05). 25-(OH)(2)D(3) level 
      was positively correlated with sweat function parameters, age and duration of 
      T2DM were negatively correlated with sweat function parameter (P < 0.05). 
      Multivariate stepwise linear regression analysis explored a significant 
      association between serum 25-(OH)(2)D(3) level with sweat function (P < 0.05). 
      CONCLUSIONS: Serum 25-(OH)(2)D(3) level was positively correlated with sweat 
      function in patients with T2DM.
CI  - (c) 2021. Italian Society of Endocrinology (SIE).
FAU - Chen, T
AU  - Chen T
AUID- ORCID: 0000-0003-1867-8373
AD  - Department of Endocrinology, Jinling Hospital, Nanjing Medical University, 305 
      East Zhongshan Road, Nanjing, 210002, Jiangsu, China.
FAU - Zhang, Z
AU  - Zhang Z
AD  - The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
FAU - Lei, H
AU  - Lei H
AD  - Department of Endocrinology, Jinling Hospital, Southern Medical University, 
      Nanjing, China.
FAU - Fen, Z
AU  - Fen Z
AD  - Department of Endocrinology, Jinling Hospital, Southern Medical University, 
      Nanjing, China.
FAU - Yuan, Y
AU  - Yuan Y
AD  - Department of Endocrinology, Jinling Hospital, Nanjing Medical University, 305 
      East Zhongshan Road, Nanjing, 210002, Jiangsu, China.
FAU - Jin, X
AU  - Jin X
AD  - Department of Endocrinology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, China.
FAU - Zhou, H
AU  - Zhou H
AD  - Department of Endocrinology, Jinling Hospital, Southern Medical University, 
      Nanjing, China.
FAU - Liu, J
AU  - Liu J
AD  - Department of Endocrinology, Jinling Hospital, Southern Medical University, 
      Nanjing, China.
FAU - Wang, W
AU  - Wang W
AD  - Department of Endocrinology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, China.
FAU - Guo, Q
AU  - Guo Q
AD  - Department of Endocrinology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, China.
FAU - Li, L
AU  - Li L
AD  - Department of Endocrinology, Chinese Navy No.971.Hospital, 22Minjiang Road, 
      Qingdao, 266000, Shandong, China. 897426605@qq.com.
FAU - Shao, J
AU  - Shao J
AD  - Department of Endocrinology, Jinling Hospital, Nanjing Medical University, 305 
      East Zhongshan Road, Nanjing, 210002, Jiangsu, China. shaojiaqing@nju.edu.cn.
LA  - eng
GR  - 81774134/National Natural Science Foundation of China/
GR  - 81873174/National Natural Science Foundation of China/
GR  - BK20150558/Natural Science Foundation of Jiangsu Province/
GR  - BK20171331/Natural Science Foundation of Jiangsu Province/
GR  - 1501120C/Postdoctoral Science Foundation of Jiangsu Province/
GR  - QNRC2016902/Young Medical Key Talents Project of Jiangsu Province/
GR  - BRA2017595/Jiangsu Province 333 Talent Funding Project/
PT  - Journal Article
DEP - 20210729
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Correlation of Data
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/blood/complications/physiopathology
MH  - *Diabetic Neuropathies/blood/diagnosis/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sweat/*metabolism
MH  - Sweat Glands/metabolism/physiopathology
MH  - Sweating/physiology
MH  - Vitamin D/*analogs & derivatives/blood
OTO - NOTNLM
OT  - Diabetic peripheral neuropathy
OT  - Serum 25-hydroxyvitamin-D
OT  - Sweat function
OT  - Type 2 diabetes mellitus
EDAT- 2021/07/30 06:00
MHDA- 2022/03/16 06:00
CRDT- 2021/07/29 12:32
PHST- 2021/05/15 00:00 [received]
PHST- 2021/07/24 00:00 [accepted]
PHST- 2021/07/30 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
PHST- 2021/07/29 12:32 [entrez]
AID - 10.1007/s40618-021-01651-z [pii]
AID - 10.1007/s40618-021-01651-z [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2022 Feb;45(2):361-368. doi: 10.1007/s40618-021-01651-z. 
      Epub 2021 Jul 29.