PMID- 34324277
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20221005
IS  - 2470-9239 (Electronic)
IS  - 2470-9239 (Linking)
VI  - 6
IP  - 4
DP  - 2021 Dec
TI  - Human herpesvirus 6 and epilepsy.
PG  - 777-780
LID - 10.1002/epi4.12531 [doi]
AB  - We investigated the association between human herpesvirus 6 (HHV-6) and mesial 
      temporal sclerosis (MTS) in 87 patients who had surgery for drug-resistant 
      epilepsy. Fifty-four had MTS, 22 focal cortical dysplasia (FCD), four tumors, 
      three vascular malformations, and three a history of encephalitis. We extracted 
      DNA from fresh brain tissue immediately after surgery and performed viral 
      detection with quantitative real-time polymerase chain reaction (PCR) or digital 
      droplet PCR specific for HHV-6A and HHV-6B. Tissue was studied with standard 
      clinical techniques, including hematoxylin and eosin, glial fibrillary acidic 
      protein, and NeuN stains. Twenty-nine of 54 patients with MTS, six of 23 with 
      focal cortical dysplasia (FCD), and one of three with a history of encephalitis 
      were positive for HHV-6 (P < .02). Febrile seizure history was not associated 
      with HHV-6 detection. Patients with MTS had significantly lower seizure onset age 
      than those with other pathologies. Thirteen patients had positron emission 
      tomography with [11C]PBR28, a marker for reactive astrocytes and activated 
      microglia; there was a trend for HHV-6-positive patients to have higher binding 
      in their seizure foci, suggesting inflammation. Our study supports a potential 
      role for HHV-6 in the etiology of MTS.
CI  - Published 2021. This article is a U.S. Government work and is in the public 
      domain in the USA. Epilepsia Open published by Wiley Periodicals LLC on behalf of 
      International League Against Epilepsy.
FAU - Theodore, William H
AU  - Theodore WH
AUID- ORCID: 0000-0002-4669-5747
AD  - Division of Intramural Research, National Institute of Neurological Disorders and 
      Stroke, Bethesda, MD, USA.
FAU - Leibovitch, Emily
AU  - Leibovitch E
AD  - Division of Intramural Research, National Institute of Neurological Disorders and 
      Stroke, Bethesda, MD, USA.
FAU - Billioux, Bridgette J
AU  - Billioux BJ
AD  - Division of Intramural Research, National Institute of Neurological Disorders and 
      Stroke, Bethesda, MD, USA.
FAU - Inati, Sara K
AU  - Inati SK
AUID- ORCID: 0000-0002-7587-5085
AD  - Division of Intramural Research, National Institute of Neurological Disorders and 
      Stroke, Bethesda, MD, USA.
FAU - Zaghloul, Kareem
AU  - Zaghloul K
AUID- ORCID: 0000-0001-8575-3578
AD  - Division of Intramural Research, National Institute of Neurological Disorders and 
      Stroke, Bethesda, MD, USA.
FAU - Heiss, John
AU  - Heiss J
AD  - Division of Intramural Research, National Institute of Neurological Disorders and 
      Stroke, Bethesda, MD, USA.
FAU - Gaillard, William D
AU  - Gaillard WD
AUID- ORCID: 0000-0001-5709-0033
AD  - Department of Neurology, Children's National Medical Center, Washington, DC, USA.
FAU - Jacobson, Steven
AU  - Jacobson S
AD  - Division of Intramural Research, National Institute of Neurological Disorders and 
      Stroke, Bethesda, MD, USA.
LA  - eng
GR  - ZIA NS002236/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20210808
PL  - United States
TA  - Epilepsia Open
JT  - Epilepsia open
JID - 101692036
RN  - 0 (DNA, Viral)
SB  - IM
MH  - DNA, Viral/analysis/genetics
MH  - *Epilepsy
MH  - *Herpesvirus 6, Human/genetics
MH  - Humans
MH  - Real-Time Polymerase Chain Reaction
MH  - Tomography, X-Ray Computed
PMC - PMC8633468
OTO - NOTNLM
OT  - HHV-6
OT  - focal epilepsy
OT  - mesial temporal sclerosis
COIS- None of the authors reports any conflicts of interest. We confirm that we have 
      read the Journal's position on issues involved in ethical publication and affirm 
      that this report is consistent with those guidelines.
EDAT- 2021/07/30 06:00
MHDA- 2022/03/19 06:00
PMCR- 2021/08/08
CRDT- 2021/07/29 12:43
PHST- 2021/07/21 00:00 [revised]
PHST- 2021/06/01 00:00 [received]
PHST- 2021/07/22 00:00 [accepted]
PHST- 2021/07/30 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2021/07/29 12:43 [entrez]
PHST- 2021/08/08 00:00 [pmc-release]
AID - EPI412531 [pii]
AID - 10.1002/epi4.12531 [doi]
PST - ppublish
SO  - Epilepsia Open. 2021 Dec;6(4):777-780. doi: 10.1002/epi4.12531. Epub 2021 Aug 8.