PMID- 34324395 OWN - NLM STAT- MEDLINE DCOM- 20230110 LR - 20230111 IS - 1547-6510 (Electronic) IS - 1040-8347 (Linking) VI - 53 IP - 1 DP - 2023 TI - Current Progress in Natural Deep Eutectic Solvents for the Extraction of Active Components from Plants. PG - 177-198 LID - 10.1080/10408347.2021.1946659 [doi] AB - In the last decade, natural deep eutectic solvents (NADESs) have gained more and more attention due to their green, convenient preparation, low toxicity and biodegradability. It is widely used in various fields, especially in the extraction of active components from plants, formed by the combination of hydrogen bond donors (HBDs) and hydrogen bond acceptors (HBAs) at a certain condition. In this article, six preparation methods of NADESs were summarized and the interactions that occur in the eutectic behavior of NADES including hydrogen bonding, electrostatic interaction and van der Waals force were also reviewed. What is more, its significant extraction capacity on flavonoids, phenols, alkaloids and plant pigments endows its extensive applications in the extraction of active components from medicinal plants. Extraction factors including solvents properties (viscosity, carbon chain length, number of hydroxyl groups), extraction condition (water content, extraction temperature, extraction time, solid-liquid ratio), extraction method and recycling method were discussed. In addition, NADESs can also be combined with other technologies, like molecular imprinting, monolithic column, to achieve efficient and specific extraction of active ingredients. Further systematic studies on the biodegradability and biotoxicity are put forward to be urgent. FAU - Zuo, Jiale AU - Zuo J AD - College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China. AD - Engineering Research Center of Dairy Products Quality and Safety Control Technology, Ministry of Education, Inner Mongolian University, Hohhot, China. FAU - Geng, Shuqin AU - Geng S AD - College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China. AD - Engineering Research Center of Dairy Products Quality and Safety Control Technology, Ministry of Education, Inner Mongolian University, Hohhot, China. FAU - Kong, Yangzhi AU - Kong Y AUID- ORCID: 0000-0003-1005-5796 AD - College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China. AD - Engineering Research Center of Dairy Products Quality and Safety Control Technology, Ministry of Education, Inner Mongolian University, Hohhot, China. FAU - Ma, Peirong AU - Ma P AD - College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China. AD - Engineering Research Center of Dairy Products Quality and Safety Control Technology, Ministry of Education, Inner Mongolian University, Hohhot, China. FAU - Fan, Zhaosheng AU - Fan Z AUID- ORCID: 0000-0002-2417-7287 AD - Technology Center, Shanghai Tobacco Group Beijing Cigarette Factory Co.,Ltd, Tongzhou Dis, Beijing, China. FAU - Zhang, Yanling AU - Zhang Y AUID- ORCID: 0000-0002-7315-5420 AD - College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China. AD - Engineering Research Center of Dairy Products Quality and Safety Control Technology, Ministry of Education, Inner Mongolian University, Hohhot, China. FAU - Dong, Alideertu AU - Dong A AD - College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China. AD - Engineering Research Center of Dairy Products Quality and Safety Control Technology, Ministry of Education, Inner Mongolian University, Hohhot, China. LA - eng PT - Journal Article PT - Review DEP - 20210729 PL - United States TA - Crit Rev Anal Chem JT - Critical reviews in analytical chemistry JID - 9004784 RN - 0 (Deep Eutectic Solvents) RN - 0 (Solvents) RN - 0 (Phenols) RN - 0 (Plant Extracts) SB - IM MH - *Deep Eutectic Solvents MH - Solvents/chemistry MH - *Phenols/chemistry MH - Green Chemistry Technology/methods MH - Plant Extracts/chemistry MH - Plants OTO - NOTNLM OT - Extraction of active components OT - hydrogen bond acceptors OT - hydrogen bond donors OT - natural deep eutectic solvents EDAT- 2021/07/30 06:00 MHDA- 2023/01/11 06:00 CRDT- 2021/07/29 17:18 PHST- 2021/07/30 06:00 [pubmed] PHST- 2023/01/11 06:00 [medline] PHST- 2021/07/29 17:18 [entrez] AID - 10.1080/10408347.2021.1946659 [pii] AID - 10.1080/10408347.2021.1946659 [doi] PST - ppublish SO - Crit Rev Anal Chem. 2023;53(1):177-198. doi: 10.1080/10408347.2021.1946659. Epub 2021 Jul 29.