PMID- 34324992
OWN - NLM
STAT- MEDLINE
DCOM- 20211228
LR  - 20211228
IS  - 1879-1336 (Electronic)
IS  - 1054-8807 (Linking)
VI  - 55
DP  - 2021 Nov-Dec
TI  - Light chain deposition disease presenting as an atrial mass: a case report and 
      review of literature.
PG  - 107368
LID - S1054-8807(21)00052-1 [pii]
LID - 10.1016/j.carpath.2021.107368 [doi]
AB  - Light chain deposition disease (LCDD) also known as nonamyloidotic immunoglobulin 
      deposition disease is a rare systemic disorder due to the abnormal deposition of 
      immunoglobulin in multiple organs caused by the clonal proliferation of B 
      lymphocytes and plasma cells. Renal involvement is the most common with cardiac 
      manifestations being the most common extra renal presentation of the disease. 
      Renal involvement is not always associated with LCDD. Isolated cardiac 
      involvement can manifest in a wide variety of ways: heart failure, 
      cardiomyopathy, arrhythmias, angina, myocardial infarction, etc. We hereby 
      present an unusual case of 59-year-old female who presented to clinic for routine 
      follow up. A murmur on physical exam was evaluated with echocardiogram which led 
      to the discovery of an incidental right atrial mass. Cardiac magnetic resonance 
      imaging was completed 6 months later for follow up which showed increasing size 
      of the mass. The mass was excised and found to be consistent with LCDD. To the 
      best of our knowledge, this is the first reported case of LCDD manifesting as an 
      atrial mass. Through this case report and review of literature we would like to 
      generate awareness among our fellow pathologists and clinicians to maintain a 
      high level of suspicion for LCDD as it can manifest in many unusual ways, with or 
      without kidney involvement.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Hudak, Madeline
AU  - Hudak M
AD  - Department of Internal Medicine, Fairfield Medical Center, Lancaster, Ohio.
FAU - Sardana, Ruhani
AU  - Sardana R
AD  - Department of Pathology, The Ohio State University Medical Center and 
      Comprehensive Cancer Center, Columbus, Ohio.
FAU - Parwani, Anil V
AU  - Parwani AV
AD  - Department of Pathology, The Ohio State University Medical Center and 
      Comprehensive Cancer Center, Columbus, Ohio.
FAU - Mathewson, Roger C
AU  - Mathewson RC
AD  - Department of Pathology, Fairfield Medical Center, Lancaster, Ohio.
FAU - Gibson, Christopher G
AU  - Gibson CG
AD  - Department of Internal Medicine, Fairfield Medical Center, Lancaster, Ohio.
FAU - Cohen, P Aryeh
AU  - Cohen PA
AD  - Department of Cardiothoracic Surgery, Fairfield Medical Center, Lancaster, Ohio.
FAU - Lazarus, John J
AU  - Lazarus JJ
AD  - Department of Cardiology, Fairfield Medical Center, Lancaster, Ohio.
FAU - Bruce, Jarrod T
AU  - Bruce JT
AD  - Department of Pulmonary Medicine, Fairfield Medical Center, Lancaster, Ohio.
FAU - Son, Jae H
AU  - Son JH
AD  - Department of Internal Medicine, Fairfield Medical Center, Lancaster, Ohio.
FAU - Tynski, Zofia
AU  - Tynski Z
AD  - Department of Pathology, Fairfield Medical Center, Lancaster, Ohio. Electronic 
      address: drztynski@fmchealth.org.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20210727
PL  - United States
TA  - Cardiovasc Pathol
JT  - Cardiovascular pathology : the official journal of the Society for Cardiovascular 
      Pathology
JID - 9212060
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Female
MH  - Heart Atria
MH  - *Heart Neoplasms/etiology
MH  - *Hematologic Diseases/diagnosis
MH  - Humans
MH  - *Immunoglobulin Light Chains/analysis
MH  - Middle Aged
OTO - NOTNLM
OT  - Light chain deposition disease
OT  - free light chains
OT  - nonamyloidotic immunoglobulin deposition disease
COIS- Declaration of competing interest The authors declare no conflicts of interest.
EDAT- 2021/07/30 06:00
MHDA- 2021/12/29 06:00
CRDT- 2021/07/29 20:13
PHST- 2020/10/22 00:00 [received]
PHST- 2021/06/30 00:00 [revised]
PHST- 2021/07/02 00:00 [accepted]
PHST- 2021/07/30 06:00 [pubmed]
PHST- 2021/12/29 06:00 [medline]
PHST- 2021/07/29 20:13 [entrez]
AID - S1054-8807(21)00052-1 [pii]
AID - 10.1016/j.carpath.2021.107368 [doi]
PST - ppublish
SO  - Cardiovasc Pathol. 2021 Nov-Dec;55:107368. doi: 10.1016/j.carpath.2021.107368. 
      Epub 2021 Jul 27.