PMID- 34325160
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1879-0380 (Electronic)
IS  - 0959-437X (Linking)
VI  - 71
DP  - 2021 Dec
TI  - Recombination-mediated genome rearrangements.
PG  - 63-71
LID - S0959-437X(21)00078-2 [pii]
LID - 10.1016/j.gde.2021.06.008 [doi]
AB  - Homologous recombination (HR) is a universal DNA double-strand break (DSB) repair 
      pathway that uses an intact DNA molecule as a template. Signature HR reactions 
      are homology search and DNA strand invasion catalyzed by the prototypical 
      RecA-ssDNA filament (Rad51 and Dmc1 in eukaryotes), which produces heteroduplex 
      DNA-containing joint molecules (JMs). These reactions uniquely infringe on the 
      DNA strands association established at replication, on the basis of substantial 
      sequence similarity. For that reason, and despite the high fidelity of its 
      templated nature, DSB repair by HR authorizes the alteration of genome structure, 
      guided by repetitive DNA elements. The resulting structural variations (SVs) can 
      involve vast genomic regions, potentially affecting multiple coding sequences and 
      regulatory elements at once, with possible pathological consequences. Here, we 
      discuss recent advances in our understanding of genetic and molecular 
      vulnerabilities of HR leading to SVs, and of the various fidelity-enforcing 
      factors acting across scales on the balancing act of this complex pathway. An 
      emphasis is put on extra-chomosomal DNAs, both product of, and substrate for 
      HR-mediated chromosomal rearrangements.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Savocco, Jerome
AU  - Savocco J
AD  - Universite de Lyon, ENS de Lyon, Universite Claude Bernard, CNRS UMR5239, 
      Laboratoire de Biologie et Modelisation de la Cellule, Lyon, France.
FAU - Piazza, Aurele
AU  - Piazza A
AD  - Universite de Lyon, ENS de Lyon, Universite Claude Bernard, CNRS UMR5239, 
      Laboratoire de Biologie et Modelisation de la Cellule, Lyon, France. Electronic 
      address: aurele.piazza@ens-lyon.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210727
PL  - England
TA  - Curr Opin Genet Dev
JT  - Current opinion in genetics & development
JID - 9111375
RN  - 0 (DNA, Single-Stranded)
RN  - EC 2.7.7.- (Rad51 Recombinase)
SB  - IM
MH  - *DNA Breaks, Double-Stranded
MH  - DNA Repair/genetics
MH  - DNA Replication
MH  - DNA, Single-Stranded/genetics
MH  - *Homologous Recombination/genetics
MH  - Rad51 Recombinase/chemistry/genetics/metabolism
EDAT- 2021/07/30 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/07/29 20:17
PHST- 2021/05/15 00:00 [received]
PHST- 2021/06/20 00:00 [revised]
PHST- 2021/06/29 00:00 [accepted]
PHST- 2021/07/30 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/07/29 20:17 [entrez]
AID - S0959-437X(21)00078-2 [pii]
AID - 10.1016/j.gde.2021.06.008 [doi]
PST - ppublish
SO  - Curr Opin Genet Dev. 2021 Dec;71:63-71. doi: 10.1016/j.gde.2021.06.008. Epub 2021 
      Jul 27.