PMID- 34325544
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230814
IS  - 2192-5682 (Print)
IS  - 2192-5690 (Electronic)
IS  - 2192-5682 (Linking)
VI  - 13
IP  - 5
DP  - 2023 Jun
TI  - Somnolence and Dizziness During Mirogabalin Treatment in Patients With 
      Neuropathic Pain Related to Lumbar Disease Who Switched From Pregabalin: A 
      Retrospective Study.
PG  - 1319-1324
LID - 10.1177/21925682211031185 [doi]
AB  - STUDY DESIGN: Multicenter retrospective study. OBJECTIVES: To investigate adverse 
      events (AEs) in patients with neuropathic pain related to lumbar disease who 
      switched to mirogabalin from pregabalin. METHODS: This study surveyed the records 
      of 82 patients with peripheral neuropathic leg pain related to lumbar disease who 
      switched to mirogabalin from pregabalin. We evaluated AEs associated with 
      pregabalin and mirogabalin, the continuation rate of mirogabalin, and the 
      pain-relieving effect at 4 weeks after switching from pregabalin to mirogabalin. 
      We compared patients who switched due to lack of efficacy (LoE group) and 
      patients who switched due to AEs (AE group). RESULTS: The incidence rates of 
      somnolence and dizziness with pregabalin were 12.2% and 14.6%, respectively, 
      while the incidence rates with mirogabalin were reduced to 7.3% for somnolence 
      and 4.9% for dizziness. The incidence of AEs with pregabalin was significantly 
      higher in the AE group (LoE group: 11.1%, AE group 100%), especially for 
      somnolence (LoE group: 3.2%, AE group: 47.1%) and dizziness (LoE group: 4.8%, AE: 
      52.9%). After switching, the incidences of AEs with mirogabalin were not 
      significantly different between the 2 groups (LoE group: 15.9%, AE group: 23.5%), 
      including for somnolence (LoE group: 7.9%, AE group: 5.9%) and dizziness (LoE 
      group: 4.8%, AE group: 5.9%). There were no significant differences in 
      continuation rate of mirogabalin or the pain-relieving effect between groups. 
      CONCLUSIONS: The patients who experience somnolence and dizziness with pregabalin 
      might be able to continue safely receiving treatment for their pain by switching 
      to mirogabalin.
FAU - Akazawa, Tsutomu
AU  - Akazawa T
AUID- ORCID: 0000-0003-2348-0994
AD  - Department of Orthopaedic Surgery, St. Marianna University School of Medicine, 
      Kawasaki, Kanagawa, Japan.
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
FAU - Inoue, Gen
AU  - Inoue G
AUID- ORCID: 0000-0001-6500-9004
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Kitasato University School of Medicine, 
      Sagamihara, Kanagawa, Japan.
FAU - Tanaka, Masahiro
AU  - Tanaka M
AD  - Department of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, 
      Kanagawa, Japan.
FAU - Umehara, Tasuku
AU  - Umehara T
AD  - Department of Orthopaedic Surgery, St. Marianna University Yokohama Seibu 
      Hospital, Yokohama, Kanagawa, Japan.
FAU - Nagai, Toshihiro
AU  - Nagai T
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Tokai University Oiso Hospital, Oiso, 
      Kanagawa, Japan.
FAU - Oshita, Yusuke
AU  - Oshita Y
AUID- ORCID: 0000-0003-1908-2803
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Showa University Northern Yokohama Hospital, 
      Yokohama, Kanagawa, Japan.
FAU - Imura, Takayuki
AU  - Imura T
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Kitasato University School of Medicine, 
      Sagamihara, Kanagawa, Japan.
FAU - Miyagi, Masayuki
AU  - Miyagi M
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Kitasato University School of Medicine, 
      Sagamihara, Kanagawa, Japan.
FAU - Saito, Wataru
AU  - Saito W
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Kitasato University School of Medicine, 
      Sagamihara, Kanagawa, Japan.
FAU - Sako, Kosuke
AU  - Sako K
AD  - Department of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, 
      Kanagawa, Japan.
FAU - Nomura, Satoshi
AU  - Nomura S
AD  - Department of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, 
      Kanagawa, Japan.
FAU - Hiyama, Akihiko
AU  - Hiyama A
AUID- ORCID: 0000-0002-2474-9118
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, 
      Kanagawa, Japan.
FAU - Katoh, Hiroyuki
AU  - Katoh H
AUID- ORCID: 0000-0003-0046-3008
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, 
      Kanagawa, Japan.
FAU - Sakai, Daisuke
AU  - Sakai D
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, 
      Kanagawa, Japan.
FAU - Sato, Masato
AU  - Sato M
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, 
      Kanagawa, Japan.
FAU - Yoshida, Atsuhiro
AU  - Yoshida A
AD  - Department of Orthopaedic Surgery, St. Marianna University School of Medicine, 
      Kawasaki, Kanagawa, Japan.
FAU - Iinuma, Masahiro
AU  - Iinuma M
AD  - Department of Orthopaedic Surgery, St. Marianna University School of Medicine, 
      Kawasaki, Kanagawa, Japan.
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
FAU - Niki, Hisateru
AU  - Niki H
AD  - Department of Orthopaedic Surgery, St. Marianna University School of Medicine, 
      Kawasaki, Kanagawa, Japan.
FAU - Takaso, Masashi
AU  - Takaso M
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Kitasato University School of Medicine, 
      Sagamihara, Kanagawa, Japan.
FAU - Watanabe, Masahiko
AU  - Watanabe M
AD  - Kanagawa Spine Research Society, Isehara, Kanagawa, Japan.
AD  - Department of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, 
      Kanagawa, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210730
PL  - England
TA  - Global Spine J
JT  - Global spine journal
JID - 101596156
PMC - PMC10416605
OTO - NOTNLM
OT  - adverse event
OT  - lumbar disease
OT  - mirogabalin
OT  - neuropathic pain
OT  - pregabalin
COIS- The author(s) declared the following potential conflicts of interest with respect 
      to the research, authorship, and/or publication of this article: Tsutomu Akazawa 
      received honoraria from Daiichi Sankyo Co., Ltd. Hisateru Niki received 
      scholarship donations provided by Asahi Kasei Pharma Corporation, Mochida 
      Pharmaceutical Co., Ltd., and Taisho Pharmaceutical Co., Ltd. as a representative 
      of Department of Orthopaedic Surgery, St. Marianna University School of Medicine.
EDAT- 2021/07/31 06:00
MHDA- 2021/07/31 06:01
PMCR- 2021/07/30
CRDT- 2021/07/30 05:29
PHST- 2021/07/31 06:01 [medline]
PHST- 2021/07/31 06:00 [pubmed]
PHST- 2021/07/30 05:29 [entrez]
PHST- 2021/07/30 00:00 [pmc-release]
AID - 10.1177_21925682211031185 [pii]
AID - 10.1177/21925682211031185 [doi]
PST - ppublish
SO  - Global Spine J. 2023 Jun;13(5):1319-1324. doi: 10.1177/21925682211031185. Epub 
      2021 Jul 30.