PMID- 34325877
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20220131
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 156
DP  - 2021 Oct 1
TI  - Long-term (>/=15 years) Follow-up of Percutaneous Coronary Intervention of 
      Unprotected Left Main (From the GRAVITY Registry).
PG  - 72-78
LID - S0002-9149(21)00566-X [pii]
LID - 10.1016/j.amjcard.2021.06.008 [doi]
AB  - Long term survival and its determinants after Percutaneous Coronary Intervention 
      (PCI) on Unprotected Left Main Coronary Artery (ULMCA) remain to be appraised. In 
      9 European Centers 470 consecutive patients performing PCI on ULMCA between 2002 
      and 2005 were retrospectively enrolled. Survival from all cause and 
      cardiovascular (CV) death were the primary end points, while their predictors at 
      multivariate analysis the secondary ones. Among the overall cohort 81.5% of 
      patients were male and mean age was 66 +/- 12 years. After 15 years (IQR 13 to 16), 
      223 patients (47%) died, 81 (17.2%) due to CV etiology. At multivariable 
      analysis, older age (HR 1.06, 95%CI 1.02 to 1.11), LVEF < 35% (HR 2.97, 95%CI 
      1.24 to 7.15) and number of vessels treated during the index PCI (HR 1.75, 95%CI 
      1.12 to 2.72) were related to all-cause mortality, while only LVEF <35% (HR 4.71, 
      95%CI 1.90 to 11.66) to CV death. Repeated PCI on ULMCA occurred in 91 (28%) 
      patients during the course of follow up and did not significantly impact on 
      freedom from all-cause or CV mortality. In conclusion, in a large, unselected 
      population treated with PCI on ULMCA, 47% died after 15 years, 17% due to CV 
      causes. Age, number of vessels treated during index PCI and depressed LVEF 
      increased risk of all cause death, while re-PCI on ULMCA did not impact survival.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - D'Ascenzo, Fabrizio
AU  - D'Ascenzo F
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy. Electronic address: fabrizio.dascenzo@gmail.com.
FAU - Elia, Edoardo
AU  - Elia E
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy.
FAU - Marengo, Giorgio
AU  - Marengo G
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy.
FAU - Wanha, Wojciech
AU  - Wanha W
AD  - Division of Cardiology and Structural Heart Diseases, Medical University of 
      Silesia, Katowice, Poland.
FAU - Gonzalez Ferreiro, R
AU  - Gonzalez Ferreiro R
AD  - Department of Cardiology, University Hospital Alvaro Cunqueiro, Vigo, Spain.
FAU - Truffa, Alessandra
AU  - Truffa A
AD  - Division of Cardiology, Ospedale di Asti, Italy.
FAU - Trabattoni, Daniela
AU  - Trabattoni D
AD  - Division of Cardiology, Ospedale Monzino, Milan, Italy.
FAU - Figini, Filippo
AU  - Figini F
AD  - Division of Cardiology, Pederzoli Hospital-Peschiera del Garda, Verona, Italy.
FAU - Verardi, Roberto
AU  - Verardi R
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy; U.O.C. Cardiologia, Ospedale Maggiore, Bologna, Italy.
FAU - Di Palma, G
AU  - Di Palma G
AD  - Cardiovascular Research Team, San Carlo Clinic, Milan, Italy.
FAU - Infusino, Fabio
AU  - Infusino F
AD  - Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, 
      Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
FAU - Pivato, Carlo
AU  - Pivato C
AD  - Cardio Center, Humanitas Clinical and Research Center IRCCS, Rozzano-Milan, 
      Italy.
FAU - Ochala, Andrzej
AU  - Ochala A
AD  - Division of Cardiology and Structural Heart Diseases, Medical University of 
      Silesia, Katowice, Poland.
FAU - Omede, Pierluigi
AU  - Omede P
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy.
FAU - Milewski, Marek
AU  - Milewski M
AD  - Division of Cardiology and Structural Heart Diseases, Medical University of 
      Silesia, Katowice, Poland.
FAU - Estevez, Roi
AU  - Estevez R
AD  - Department of Cardiology, University Hospital Alvaro Cunqueiro, Vigo, Spain.
FAU - Raporeiras Roubin, S
AU  - Raporeiras Roubin S
AD  - Department of Cardiology, University Hospital Alvaro Cunqueiro, Vigo, Spain.
FAU - De Filippo, O
AU  - De Filippo O
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy.
FAU - Conrotto, Federico
AU  - Conrotto F
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy.
FAU - Montefusco, Antonio
AU  - Montefusco A
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy.
FAU - Gili, Sebastiano
AU  - Gili S
AD  - Division of Cardiology, Ospedale Monzino, Milan, Italy.
FAU - Cortese, Bernardo
AU  - Cortese B
AD  - Cardiovascular Research Team, San Carlo Clinic, Milan, Italy.
FAU - Dusi, Veronica
AU  - Dusi V
AD  - Department of Molecular Medicine, Section of Cardiology, University of Pavia, 
      Pavia, Italy.
FAU - Gallone, Guglielmo
AU  - Gallone G
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy.
FAU - Manfredi, Roberto
AU  - Manfredi R
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy.
FAU - Mancone, Massimo
AU  - Mancone M
AD  - Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, 
      Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
FAU - Biondi Zoccai, G
AU  - Biondi Zoccai G
AD  - Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University, 
      Rome, Italy; Mediterranea Cardiocentro, Naples, Italy.
FAU - Casella, Gianni
AU  - Casella G
AD  - U.O.C. Cardiologia, Ospedale Maggiore, Bologna, Italy.
FAU - Templin, Christian
AU  - Templin C
AD  - Department of Cardiology, University Heart Center, University Hospital Zurich, 
      Zurich, Switzerland.
FAU - Stefanini, Giulio
AU  - Stefanini G
AD  - Cardio Center, Humanitas Clinical and Research Center IRCCS, Rozzano-Milan, 
      Italy.
FAU - Wojakowski, Wojciech
AU  - Wojakowski W
AD  - Division of Cardiology and Structural Heart Diseases, Medical University of 
      Silesia, Katowice, Poland.
FAU - Sheiban, Imad
AU  - Sheiban I
AD  - Division of Cardiology, Pederzoli Hospital-Peschiera del Garda, Verona, Italy.
FAU - De Ferrari, G M
AU  - De Ferrari GM
AD  - Department of Medical Science, Citta Della Salute e della Scienza, Division of 
      Cardiology, Turin, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20210727
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Coronary Angiography
MH  - Coronary Artery Disease/diagnosis/mortality/*surgery
MH  - Coronary Vessels/*diagnostic imaging/surgery
MH  - Europe/epidemiology
MH  - Follow-Up Studies
MH  - *Forecasting
MH  - Humans
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/*methods
MH  - *Registries
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Survival Rate/trends
EDAT- 2021/07/31 06:00
MHDA- 2021/09/21 06:00
CRDT- 2021/07/30 05:41
PHST- 2021/03/28 00:00 [received]
PHST- 2021/06/04 00:00 [revised]
PHST- 2021/06/14 00:00 [accepted]
PHST- 2021/07/31 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2021/07/30 05:41 [entrez]
AID - S0002-9149(21)00566-X [pii]
AID - 10.1016/j.amjcard.2021.06.008 [doi]
PST - ppublish
SO  - Am J Cardiol. 2021 Oct 1;156:72-78. doi: 10.1016/j.amjcard.2021.06.008. Epub 2021 
      Jul 27.