PMID- 34326955
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210731
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 12
IP  - 7
DP  - 2021 Jul 15
TI  - Multi-omics: Opportunities for research on mechanism of type 2 diabetes mellitus.
PG  - 1070-1080
LID - 10.4239/wjd.v12.i7.1070 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a burdensome global disease. In-depth 
      understanding of its mechanism will help to optimize diagnosis and treatment, 
      which reduces the burden. Multi-omics research has unparalleled advantages in 
      contributing to the overall understanding of the mechanism of this chronic 
      metabolic disease. In the past two decades, the study of multi-omics on 
      T2DM-related intestinal flora perturbation and plasma dyslipidemia has shown 
      tremendous potential and is expected to achieve major breakthroughs. The 
      regulation of intestinal flora in diabetic patients has been confirmed by 
      multiple studies. The use of metagenomics, 16S RNA sequencing, and metabolomics 
      has comprehensively identified the overall changes in the intestinal flora and 
      the metabolic disturbances that could directly or indirectly participate in the 
      intestinal flora-host interactions. Lipidomics combined with other "omics" has 
      characterized lipid metabolism disorders in T2DM. The combined application and 
      cross-validation of multi-omics can screen for dysregulation in T2DM, which will 
      provide immense opportunities to understand the mechanisms behind T2DM.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Wang, Shuai
AU  - Wang S
AD  - Institute of Toxicology, School of Public Health, Cheeloo College of Medicine, 
      Shandong University, Jinan 250012, Shandong Province, China.
FAU - Yong, Hui
AU  - Yong H
AD  - Institute of Toxicology, School of Public Health, Cheeloo College of Medicine, 
      Shandong University, Jinan 250012, Shandong Province, China.
FAU - He, Xiao-Dong
AU  - He XD
AD  - Department of Physical and Chemical Inspection, School of Public Health, Cheeloo 
      College of Medicine, Shandong University, Jinan 250012, Shandong Province, China. 
      xiaodong.he@sdu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC8311486
OTO - NOTNLM
OT  - Dyslipidemias
OT  - Gastrointestinal microbiome
OT  - Intestinal flora
OT  - Lipid metabolism disorders
OT  - Metabolomics
OT  - Type 2 diabetes mellitus
COIS- Conflict-of-interest statement: The authors declare no conflicts of interest for 
      this article.
EDAT- 2021/07/31 06:00
MHDA- 2021/07/31 06:01
PMCR- 2021/07/15
CRDT- 2021/07/30 06:45
PHST- 2021/01/24 00:00 [received]
PHST- 2021/03/22 00:00 [revised]
PHST- 2021/05/22 00:00 [accepted]
PHST- 2021/07/30 06:45 [entrez]
PHST- 2021/07/31 06:00 [pubmed]
PHST- 2021/07/31 06:01 [medline]
PHST- 2021/07/15 00:00 [pmc-release]
AID - 10.4239/wjd.v12.i7.1070 [doi]
PST - ppublish
SO  - World J Diabetes. 2021 Jul 15;12(7):1070-1080. doi: 10.4239/wjd.v12.i7.1070.