PMID- 34327609
OWN - NLM
STAT- MEDLINE
DCOM- 20220425
LR  - 20220425
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 200
IP  - 5
DP  - 2022 May
TI  - Hydrogen-Rich Medium Regulates Cr(VI)-Induced ER Stress and Autophagy Signaling 
      in DF-1 Cells.
PG  - 2329-2337
LID - 10.1007/s12011-021-02850-8 [doi]
AB  - Related studies have shown that chromium (Cr) is toxic to cells, and hydrogen can 
      protect cells by regulating endoplasmic reticulum (ER) stress and autophagy. 
      However, there are few reports on the protective effects of hydrogen on heavy 
      metal-induced cell damage. The objective of this study was to investigate the 
      protection of hydrogen-rich medium (HRM) on Cr(VI)-induced ER stress and 
      autophagy in DF-1 cells. Therefore, HRM were pretreated for 30 min before Cr(VI) 
      treatment, and detected the autophagy and ER stress-related indicators to 
      determine the role of HRM. The results showed that HRM could reduce the cell 
      damage caused by Cr(VI), and 3-methyladenine (3-MA) could protect cells by 
      inhibiting over autophagy. HRM can reverse the changes of ER stress- and 
      autophagy-related indexes caused by Cr(VI), and inhibit the excessive autophagy 
      caused by Cr(VI). In conclusion, HRM can protect cells from damage induced by 
      Cr(VI), and play a role by inhibiting ER stress-mediated autophagy.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Liu, Kangping
AU  - Liu K
AUID- ORCID: 0000-0001-5570-8004
AD  - College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, 
      Shandong, China.
FAU - Cui, Yukun
AU  - Cui Y
AUID- ORCID: 0000-0002-6951-1904
AD  - Research Center for Animal Disease Control Engineering, Shandong Agricultural 
      University, Tai'an, 271018, Shandong, China.
FAU - Li, Hongyan
AU  - Li H
AUID- ORCID: 0000-0002-7436-6393
AD  - Central Hospital of Tai'an City, Tai'an, 271018, Shandong, China.
FAU - Qi, Changxi
AU  - Qi C
AUID- ORCID: 0000-0002-6030-751X
AD  - Research Center for Animal Disease Control Engineering, Shandong Agricultural 
      University, Tai'an, 271018, Shandong, China.
FAU - Cheng, Guodong
AU  - Cheng G
AUID- ORCID: 0000-0003-3378-9231
AD  - College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, 
      Shandong, China.
FAU - Gao, Xin
AU  - Gao X
AUID- ORCID: 0000-0001-6515-5239
AD  - College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, 
      Shandong, China.
FAU - Zhang, Zhuanglong
AU  - Zhang Z
AUID- ORCID: 0000-0002-0230-8792
AD  - College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, 
      Shandong, China.
FAU - Liu, Yongxia
AU  - Liu Y
AUID- ORCID: 0000-0001-6125-8599
AD  - Research Center for Animal Disease Control Engineering, Shandong Agricultural 
      University, Tai'an, 271018, Shandong, China. liuyongxia@sdau.edu.cn.
FAU - Liu, Jianzhu
AU  - Liu J
AUID- ORCID: 0000-0003-3634-0712
AD  - College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, 
      Shandong, China. liujz@sdau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210730
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0R0008Q3JB (Chromium)
RN  - 18540-29-9 (chromium hexavalent ion)
RN  - 7YNJ3PO35Z (Hydrogen)
SB  - IM
MH  - *Apoptosis
MH  - Autophagy
MH  - Chromium/toxicity
MH  - Endoplasmic Reticulum Stress
MH  - *Hydrogen/pharmacology
OTO - NOTNLM
OT  - COX-2
OT  - Chromium(VI)
OT  - DF-1 cells
OT  - Endoplasmic reticulum stress
OT  - Hydrogen-rich medium
EDAT- 2021/07/31 06:00
MHDA- 2022/04/26 06:00
CRDT- 2021/07/30 06:56
PHST- 2021/07/05 00:00 [received]
PHST- 2021/07/21 00:00 [accepted]
PHST- 2021/07/31 06:00 [pubmed]
PHST- 2022/04/26 06:00 [medline]
PHST- 2021/07/30 06:56 [entrez]
AID - 10.1007/s12011-021-02850-8 [pii]
AID - 10.1007/s12011-021-02850-8 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2022 May;200(5):2329-2337. doi: 10.1007/s12011-021-02850-8. 
      Epub 2021 Jul 30.