PMID- 34329768
OWN - NLM
STAT- MEDLINE
DCOM- 20220201
LR  - 20220201
IS  - 1878-1519 (Electronic)
IS  - 1569-9048 (Linking)
VI  - 294
DP  - 2021 Dec
TI  - Computational model of trachea-alveoli gas movement during spontaneous breathing.
PG  - 103767
LID - S1569-9048(21)00152-X [pii]
LID - 10.1016/j.resp.2021.103767 [doi]
AB  - A computational model of the transport of gases involved in spontaneous 
      breathing, from the trachea inlet to the alveoli was developed for healthy 
      patients. Convective and diffusive transport mechanisms were considered 
      simultaneously, using a diffusion coefficient (D) that has considered the four 
      main species of gases present in the exchange carried out by the human lung, 
      nitrogen (N(2)), oxygen (O(2)), carbon dioxide (CO(2)) and water vapor (H(2)O). A 
      Matlab(R) script was programmed to simulate the trachea-alveolus gas exchange model 
      under three respiratory frequencies: 12, 24 and 40 breaths per minute (BPM), each 
      with three diaphragmatic movements of 2 cm, 4 cm, and 6 cm. During the 
      simulations, the CO(2) inlet concentrations in the alveoli and the O(2) 
      concentration at the inlet of the trachea were kept constant. A simplified but 
      stable model of mass transport between the trachea and alveoli was obtained, 
      allowing the concentrations to be determined dynamically at the selected test 
      points in the airway.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Jimenez-Posada, L D
AU  - Jimenez-Posada LD
AD  - Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: 
      leon.jimenez@eia.edu.co.
FAU - Maya, Juan C
AU  - Maya JC
AD  - Universidad Nacional de Colombia - Sede Medellin, Facultad de Minas - 
      Departamento de Procesos y Energia - TAYEA, Cr 80 No 65 - 233, Medellin, 050034, 
      Colombia. Electronic address: jcmaya@unal.edu.co.
FAU - Sanchez-Ocampo, M
AU  - Sanchez-Ocampo M
AD  - Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: 
      maria.sanchez22@eia.edu.co.
FAU - Lopez-Isaza, S
AU  - Lopez-Isaza S
AD  - Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: 
      sergio.lopez@eia.edu.co.
FAU - Cortes-Ospina, S
AU  - Cortes-Ospina S
AD  - Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: 
      Santiago.cortes80@eia.edu.co.
FAU - Montagut-Ferizzola, Y J
AU  - Montagut-Ferizzola YJ
AD  - Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: 
      yeison.montagut@eia.edu.co.
FAU - Torres, R
AU  - Torres R
AD  - Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: 
      robinson.torres@eia.edu.co.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210728
PL  - Netherlands
TA  - Respir Physiol Neurobiol
JT  - Respiratory physiology & neurobiology
JID - 101140022
SB  - IM
MH  - Humans
MH  - *Models, Theoretical
MH  - Pulmonary Alveoli/*physiology
MH  - Pulmonary Gas Exchange/*physiology
MH  - *Respiration
MH  - Trachea/*physiology
OTO - NOTNLM
OT  - Convective and diffusive gas transport
OT  - Lung model simulations
OT  - Mathematical model
OT  - Oxygen and carbon dioxide transport
OT  - Pulmonary gas transport models
EDAT- 2021/07/31 06:00
MHDA- 2022/02/02 06:00
CRDT- 2021/07/30 20:13
PHST- 2021/05/07 00:00 [received]
PHST- 2021/07/15 00:00 [revised]
PHST- 2021/07/25 00:00 [accepted]
PHST- 2021/07/31 06:00 [pubmed]
PHST- 2022/02/02 06:00 [medline]
PHST- 2021/07/30 20:13 [entrez]
AID - S1569-9048(21)00152-X [pii]
AID - 10.1016/j.resp.2021.103767 [doi]
PST - ppublish
SO  - Respir Physiol Neurobiol. 2021 Dec;294:103767. doi: 10.1016/j.resp.2021.103767. 
      Epub 2021 Jul 28.