PMID- 34331958
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20220216
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 240
DP  - 2021 Oct 15
TI  - Targeting executive function for weight loss in adults with overweight or 
      obesity.
PG  - 113540
LID - S0031-9384(21)00230-4 [pii]
LID - 10.1016/j.physbeh.2021.113540 [doi]
AB  - Obesity is associated with a multitude of negative health sequalae. Behavioral 
      weight loss (BWL) is currently the recommended behavioral treatment for obesity; 
      however, it is not effective for approximately half of the individuals who 
      participate. BWL requires individuals to carry out many tasks requiring executive 
      function (EF; i.e., higher order cognitive functions such as planning and problem 
      solving) in order to be successful. Growing research supports that lower EF may 
      be associated with attenuated weight loss following BWL, and targeting EF in 
      treatment could improve outcomes. This paper aims to describe the rationale for 
      the development of Novel Executive Function Training for Obesity (NEXT), which 
      adapts Compensatory Cognitive Training to be delivered in conjunction with BWL. 
      We summarize evidence relating EF to obesity and reduced weight loss following 
      BWL, as well as the past success of cognitive training on EF. Then we describe 
      the treatment model for NEXT followed by initial data suggesting that NEXT is 
      feasible and acceptable and may impact EF and weight. Obesity treatments 
      incorporating cognitive training, especially those that train compensatory 
      strategies, may improve weight-loss outcomes and provide a more durable treatment 
      than traditional interventions, but larger randomized control trials are 
      necessary.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Eichen, Dawn M
AU  - Eichen DM
AD  - Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, San 
      Diego, CA 92093 USA. Electronic address: deichen@ucsd.edu.
FAU - Pasquale, Ellen K
AU  - Pasquale EK
AD  - Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, San 
      Diego, CA 92093 USA.
FAU - Twamley, Elizabeth W
AU  - Twamley EW
AD  - Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, San 
      Diego, CA 92093 USA; Center of Excellence for Stress and Mental Health and 
      Research Service, VA San Diego Healthcare System, USA.
FAU - Boutelle, Kerri N
AU  - Boutelle KN
AD  - Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, San 
      Diego, CA 92093 USA; Department of Psychiatry, University of California San 
      Diego, 9500 Gilman Dr, San Diego, CA 92093 USA; Herbert Wertheim School of Public 
      Health and Human Longevity Science, University of California San Diego, 9500 
      Gilman Dr, San Diego, CA 92093 USA.
LA  - eng
GR  - K23 DK114480/DK/NIDDK NIH HHS/United States
GR  - UL1 TR001442/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210728
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
SB  - IM
MH  - Adult
MH  - *Executive Function
MH  - Humans
MH  - Obesity/therapy
MH  - Overweight
MH  - Treatment Outcome
MH  - *Weight Loss
PMC - PMC8823407
MID - NIHMS1773365
OTO - NOTNLM
OT  - Cognitive training
OT  - Eating behavior
OT  - Executive function
OT  - Physical activity
OT  - Weight loss
COIS- Declaration of Competing Interest: None
EDAT- 2021/08/01 06:00
MHDA- 2021/10/26 06:00
PMCR- 2022/02/08
CRDT- 2021/07/31 20:11
PHST- 2020/12/23 00:00 [received]
PHST- 2021/07/09 00:00 [revised]
PHST- 2021/07/26 00:00 [accepted]
PHST- 2021/08/01 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/07/31 20:11 [entrez]
PHST- 2022/02/08 00:00 [pmc-release]
AID - S0031-9384(21)00230-4 [pii]
AID - 10.1016/j.physbeh.2021.113540 [doi]
PST - ppublish
SO  - Physiol Behav. 2021 Oct 15;240:113540. doi: 10.1016/j.physbeh.2021.113540. Epub 
      2021 Jul 28.