PMID- 34332429
OWN - NLM
STAT- MEDLINE
DCOM- 20211019
LR  - 20211019
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 235
DP  - 2021 Sep
TI  - Enhancing stress reactivity and wellbeing in early schizophrenia: A randomized 
      controlled trial of Integrated Coping Awareness Therapy (I-CAT).
PG  - 91-101
LID - S0920-9964(21)00275-9 [pii]
LID - 10.1016/j.schres.2021.07.022 [doi]
AB  - Individuals with schizophrenia spectrum disorders (SSD) are at heightened risk 
      for exposure to stressful life events which can lead to increased sensitivity to 
      stress and a dysregulated stress response, which are in turn associated with poor 
      long-term functioning. Stress reactivity is thus a promising treatment target in 
      the early stages of SSD. Integrated-Coping Awareness Therapy (I-CAT) is a 
      manualized intervention integrating mindfulness and positive psychology to target 
      a dysregulated stress response in SSD. The current study is a preliminary 
      randomized-controlled trial (RCT) comparing I-CAT (n = 18) with treatment as 
      usual (TAU; n = 18) in individuals in the early stages of SSD. I-CAT was 
      hypothesized to be more effective than TAU on primary outcomes: increasing 
      positive emotions, decreasing negative emotions, reducing stress, and improving 
      functioning and quality of life; and secondary outcomes: reducing symptoms, 
      increasing mindfulness, and improving overall well-being. Excellent therapy 
      attendance rates, low study attrition, and positive participant feedback 
      demonstrated that I-CAT was a feasible and well-tolerated psychosocial 
      intervention. Results suggest I-CAT led to greater reduction in symptoms (i.e., 
      overall, negative, and disorganized symptoms), increased observational 
      mindfulness, increased endorsement of a sense of purpose in life, and 
      preservation of work abilities and school social functioning compared with TAU. 
      Future work should replicate and extend these findings in a larger-scale RCT.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Halverson, Tate F
AU  - Halverson TF
AD  - Department of Psychology and Neuroscience, The University of North Carolina at 
      Chapel Hill, United States of America. Electronic address: 
      tate.halverson@unc.edu.
FAU - Meyer-Kalos, Piper S
AU  - Meyer-Kalos PS
AD  - Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical 
      School, United States of America.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry, The University of North Carolina at Chapel Hill, United 
      States of America.
FAU - Gaylord, Susan A
AU  - Gaylord SA
AD  - Department of Physical Medicine and Rehabilitation, The University of North 
      Carolina at Chapel Hill, United States of America.
FAU - Palsson, Olafur S
AU  - Palsson OS
AD  - Department of Medicine, The University of North Carolina at Chapel Hill, United 
      States of America.
FAU - Nye, Lana
AU  - Nye L
AD  - College of Social Work, The University of Utah, United States of America.
FAU - Algoe, Sara B
AU  - Algoe SB
AD  - Department of Psychology and Neuroscience, The University of North Carolina at 
      Chapel Hill, United States of America.
FAU - Grewen, Karen
AU  - Grewen K
AD  - Department of Psychiatry, The University of North Carolina at Chapel Hill, United 
      States of America.
FAU - Penn, David L
AU  - Penn DL
AD  - Department of Psychology and Neuroscience, The University of North Carolina at 
      Chapel Hill, United States of America; School of Behavioural and Health Sciences, 
      Australian Catholic University, Australia.
LA  - eng
GR  - R33 MH100250/MH/NIMH NIH HHS/United States
GR  - R21 MH100250/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20210728
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adaptation, Psychological
MH  - Humans
MH  - *Mindfulness
MH  - Quality of Life
MH  - *Schizophrenia/therapy
OTO - NOTNLM
OT  - Early intervention
OT  - First episode psychosis
OT  - Mindfulness
OT  - Positive psychology
OT  - Stress reactivity
EDAT- 2021/08/01 06:00
MHDA- 2021/10/21 06:00
CRDT- 2021/07/31 20:28
PHST- 2020/10/20 00:00 [received]
PHST- 2021/03/14 00:00 [revised]
PHST- 2021/07/19 00:00 [accepted]
PHST- 2021/08/01 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/07/31 20:28 [entrez]
AID - S0920-9964(21)00275-9 [pii]
AID - 10.1016/j.schres.2021.07.022 [doi]
PST - ppublish
SO  - Schizophr Res. 2021 Sep;235:91-101. doi: 10.1016/j.schres.2021.07.022. Epub 2021 
      Jul 28.