PMID- 3433247
OWN - NLM
STAT- MEDLINE
DCOM- 19880316
LR  - 20141120
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 58
IP  - 3
DP  - 1987 Oct 28
TI  - Kinetics and in vivo distribution of in-111-labelled platelets and platelet 
      function in familial hypercholesterolaemia.
PG  - 811-6
AB  - The kinetics, in vivo distribution and sites of sequestration of autologous 
      In-111-labelled platelets and other platelet function parameters were studied in 
      ten patients with type IIa or IIb familial hypercholesterolaemia and thrombotic 
      complications of atherosclerosis. The in vitro platelet aggregation response to 
      ADP (P = 0.50) and collagen (P = 0.46); binding of fibrinogen to platelets (P = 
      0.61); and plasma beta-thromboglobulin levels (P = 0.42) of the patients and 
      normal reference subjects did not differ significantly. The in vivo distribution 
      of In-111-labelled platelets at equilibrium was within normal limits, and at the 
      end of platelet life-span the sequestration pattern of labelled platelets in the 
      reticuloendothelial system was also normal (spleen P = 0.31; liver P = 0.54). 
      There was minimal evidence of in vivo platelet activation: only mean platelet 
      lifespan (MPLS), 195 +/- 57 hours (difference between mean MPLS of patients and 
      controls was 25 hours, with a 95% confidence interval from 23 to 31 hours; P = 
      0.02); mean platelet platelet turnover, 2298 +/- 824 platelets/microliter/hour (P 
      = 0.005); plasma platelet factor 4 (P = 0.02); and the mean circulating platelet 
      aggregate ratio, 0.8 +/- 0.1 (P = 0.02); differed significantly from normal. 
      These results suggest that abnormalities of platelet function and kinetics 
      observed in type II hyperlipoproteinaemia cannot be ascribed wholly to the 
      hyperlipidaemia, but may be induced by the associated atherosclerosis.
FAU - Wessels, P
AU  - Wessels P
AD  - MRC Blood Platelet Research Unit, University of the Orange Free State, 
      Bloemfontein, South Africa.
FAU - Heyns, A D
AU  - Heyns AD
FAU - Esterhuysen, A J
AU  - Esterhuysen AJ
FAU - Badenhorst, P N
AU  - Badenhorst PN
FAU - Lotter, M G
AU  - Lotter MG
FAU - Pieters, H
AU  - Pieters H
FAU - Kotze, H F
AU  - Kotze HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Indium Radioisotopes)
SB  - IM
MH  - Adult
MH  - Arteriosclerosis/blood/complications
MH  - Blood Platelets/*physiology
MH  - Cell Survival
MH  - Humans
MH  - Hyperlipoproteinemia Type II/*blood/complications
MH  - In Vitro Techniques
MH  - Indium Radioisotopes
MH  - Kinetics
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation
EDAT- 1987/10/28 00:00
MHDA- 1987/10/28 00:01
CRDT- 1987/10/28 00:00
PHST- 1987/10/28 00:00 [pubmed]
PHST- 1987/10/28 00:01 [medline]
PHST- 1987/10/28 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1987 Oct 28;58(3):811-6.