PMID- 3433248
OWN - NLM
STAT- MEDLINE
DCOM- 19880316
LR  - 20141120
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 58
IP  - 3
DP  - 1987 Oct 28
TI  - Experimental studies on the relative efficacy of dermatan sulphate and heparin as 
      antithrombotic agents.
PG  - 839-42
AB  - In this study, the anticoagulant and antithrombotic properties of unfractionated 
      heparin (UFH) and dermatan sulphate (DS) were compared. The ability of UFH and DS 
      to impair thrombin generation in vitro and in ex vivo plasma samples was also 
      studied. DS has minimal anticoagulant activity by conventional assays but impairs 
      thrombin generation both in vitro and in ex vivo plasma samples. However, 
      thrombin generation could not be suppressed below about 35% of control values at 
      all doses of DS studied. While this was sufficient to impair experimental venous 
      thrombosis during 10 minutes' stasis, DS was ineffective in preventing thrombosis 
      following 20 minutes' stasis in doses up to 1.25 mg/kg. In contrast, 1 
      microgram/ml of UFH completely suppressed thrombin generation in vitro, and 150 
      micrograms/kg prevented thrombogenesis over a period of 20 minutes' stasis. 
      Neither drug prolonged the bleeding time (BT) at effective antithrombotic doses, 
      but 2.5 mg/kg UFH significantly increased the BT, whereas DS did not. While DS 
      has antithrombotic activity, it is less effective than UFH in inhibiting thrombin 
      generation, and as an antithrombotic agent.
FAU - Merton, R E
AU  - Merton RE
AD  - National Institute for Biological Standards and Control, London, U.K.
FAU - Thomas, D P
AU  - Thomas DP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Anticoagulants)
RN  - 0 (Fibrinolytic Agents)
RN  - 24967-94-0 (Dermatan Sulfate)
RN  - 9005-49-6 (Heparin)
RN  - 9007-27-6 (Chondroitin)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Animals
MH  - Anticoagulants
MH  - Chondroitin/*analogs & derivatives
MH  - Dermatan Sulfate/*pharmacology
MH  - *Fibrinolytic Agents
MH  - Heparin/*pharmacology
MH  - Humans
MH  - In Vitro Techniques
MH  - Rabbits
MH  - Thrombin/biosynthesis
MH  - Thrombophlebitis/prevention & control
EDAT- 1987/10/28 00:00
MHDA- 1987/10/28 00:01
CRDT- 1987/10/28 00:00
PHST- 1987/10/28 00:00 [pubmed]
PHST- 1987/10/28 00:01 [medline]
PHST- 1987/10/28 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1987 Oct 28;58(3):839-42.