PMID- 34332579
OWN - NLM
STAT- MEDLINE
DCOM- 20220103
LR  - 20220103
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 20
IP  - 1
DP  - 2021 Jul 31
TI  - Aggravation of functional mitral regurgitation on left ventricle stiffness in 
      type 2 diabetes mellitus patients evaluated by CMR tissue tracking.
PG  - 158
LID - 10.1186/s12933-021-01354-y [doi]
LID - 158
AB  - BACKGROUND: Functional mitral regurgitation (FMR) is one of the most common heart 
      valve diseases in diabetes and may increase left ventricular (LV) preload and 
      aggravate myocardial stiffness. This study aimed to investigate the aggravation 
      of FMR on the deterioration of LV strain in type 2 diabetes mellitus (T2DM) 
      patients and explore the independent indicators of LV peak strain (PS). MATERIALS 
      AND METHODS: In total, 157 T2DM patients (59 patients with and 98 without FMR) 
      and 52 age- and sex-matched healthy control volunteers were included and 
      underwent cardiac magnetic resonance examination. T2DM with FMR patients were 
      divided into T2DM patients with mild (n = 21), moderate (n = 19) and severe 
      (n = 19) regurgitation. LV function and global strain parameters were compared 
      among groups. Multivariate analysis was used to identify the independent 
      indicators of LV PS. RESULTS: The T2DM with FMR had lower LV strain parameters in 
      radial, circumferential and longitudinal direction than both the normal and the 
      T2DM without FMR (all P < 0.05). The mild had mainly decreased peak diastolic 
      strain rate (PDSR) compared to the normal. The moderate had decreased peak 
      systolic strain rate (PSSR) compared to the normal and PDSR compared to the mild 
      and the normal. The severe FMR group had decreased PDSR and PSSR compared to the 
      mild and the normal (all P < 0.05). Multiple linear regression showed that the 
      regurgitation degree was independent associated with radial (beta = - 0.272), 
      circumferential (beta = - 0.412) and longitudinal (beta = - 0.347) PS; the months with 
      diabetes was independently associated with radial (beta = - 0.299) and longitudinal 
      (beta = - 0.347) PS in T2DM with FMR. CONCLUSION: FMR may aggravate the 
      deterioration of LV stiffness in T2DM patients, resulting in decline of LV strain 
      and function. The regurgitation degree and months with diabetes were 
      independently correlated with LV global PS in T2DM with FMR.
CI  - (c) 2021. The Author(s).
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Yan, Wei-Feng
AU  - Yan WF
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Jiang, Li
AU  - Jiang L
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Shen, Meng-Ting
AU  - Shen MT
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Li, Yuan
AU  - Li Y
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Huang, Shan
AU  - Huang S
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Shi, Ke
AU  - Shi K
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Yang, Zhi-Gang
AU  - Yang ZG
AUID- ORCID: 0000-0001-9341-7697
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China. yangzg666@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210731
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis
MH  - Diabetic Cardiomyopathies/*diagnostic imaging/etiology/physiopathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*diagnostic imaging/physiopathology
MH  - Mitral Valve Insufficiency/*diagnostic imaging/etiology/physiopathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/physiopathology
MH  - *Ventricular Function, Left
PMC - PMC8325822
OTO - NOTNLM
OT  - Functional mitral regurgitation
OT  - Left ventricle
OT  - Magnetic resonance imaging
OT  - Strain
OT  - Type 2 diabetes mellitus
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2021/08/02 06:00
MHDA- 2022/01/04 06:00
PMCR- 2021/07/31
CRDT- 2021/08/01 20:26
PHST- 2021/06/09 00:00 [received]
PHST- 2021/07/22 00:00 [accepted]
PHST- 2021/08/01 20:26 [entrez]
PHST- 2021/08/02 06:00 [pubmed]
PHST- 2022/01/04 06:00 [medline]
PHST- 2021/07/31 00:00 [pmc-release]
AID - 10.1186/s12933-021-01354-y [pii]
AID - 1354 [pii]
AID - 10.1186/s12933-021-01354-y [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2021 Jul 31;20(1):158. doi: 10.1186/s12933-021-01354-y.