PMID- 34333170
OWN - NLM
STAT- MEDLINE
DCOM- 20211013
LR  - 20211013
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1653
DP  - 2021 Sep 13
TI  - Determination of 6 biogenic amines in food using high-performance liquid 
      chromatography-tandem mass spectrometry without derivatization.
PG  - 462415
LID - S0021-9673(21)00539-2 [pii]
LID - 10.1016/j.chroma.2021.462415 [doi]
AB  - A rapid and simple method for the determination of 6 biogenic amines (BAs) in 
      food was established on HPLC-MS /MS without derivatization. Samples were 
      extracted with 5% perchloric acid and cleaned with n-hexane for lipid removal. 
      The analytes were separated on Waters XBridge(R) HILIC (150 mm x 2.1 mm, 3.5 microm) 
      and analyzed with multiple-reaction monitoring (MRM) mode after positive 
      electrospray ionization on HPLC-MS/MS. Good linearity with high correlation 
      coefficient was obtained between 10-1000 microg/L for cadaverine (CAD), putrescine 
      (PUT), tyramine (TYR) and 2-phenylethylamine (2-PHE) and between 1-100 microg/L for 
      histamine (HIS) and tryptamine (TRY), with the detection limits of the method 
      ranging from 0.1 mg/kg for HIS and TRY, and 1.0 mg/kg for CAD, PUT, TYR and 
      2-PHE, which are under the residue limit of Chinese regulation. Spiking 
      experiments demonstrated good recoveries between 70.2-114.6%, with relative 
      standard deviations (RSDs) between 0.44-13.01%. This method was validated for BAs 
      determination in liquor, fermented meat products, vegetable products, soybean 
      products, dairy products, seafood and its derived products. These results promise 
      high feasibility for BAs monitoring in various food with easy-to-operate and fast 
      sample preparation process, stable analysis on HPLC-MS/MS without derivatization.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Zhang, Xuan
AU  - Zhang X
AD  - Key Laboratory of East China Sea Fishery Resources Exploitation, Ministry of 
      Agriculture and Rural Affairs, East China Sea Fisheries Research Institute, 
      Chinese Academy of Fishery Sciences, Shanghai 200090, China.
FAU - Hui, Yunhua
AU  - Hui Y
AD  - Key Laboratory of East China Sea Fishery Resources Exploitation, Ministry of 
      Agriculture and Rural Affairs, East China Sea Fisheries Research Institute, 
      Chinese Academy of Fishery Sciences, Shanghai 200090, China.
FAU - Jiang, Mei
AU  - Jiang M
AD  - Key Laboratory of East China Sea Fishery Resources Exploitation, Ministry of 
      Agriculture and Rural Affairs, East China Sea Fisheries Research Institute, 
      Chinese Academy of Fishery Sciences, Shanghai 200090, China.
FAU - Cai, Youqiong
AU  - Cai Y
AD  - Key Laboratory of East China Sea Fishery Resources Exploitation, Ministry of 
      Agriculture and Rural Affairs, East China Sea Fisheries Research Institute, 
      Chinese Academy of Fishery Sciences, Shanghai 200090, China.
FAU - Huang, Dongmei
AU  - Huang D
AD  - Key Laboratory of East China Sea Fishery Resources Exploitation, Ministry of 
      Agriculture and Rural Affairs, East China Sea Fisheries Research Institute, 
      Chinese Academy of Fishery Sciences, Shanghai 200090, China. Electronic address: 
      hdm2001@126.com.
FAU - Yang, Guangxin
AU  - Yang G
AD  - Key Laboratory of East China Sea Fishery Resources Exploitation, Ministry of 
      Agriculture and Rural Affairs, East China Sea Fisheries Research Institute, 
      Chinese Academy of Fishery Sciences, Shanghai 200090, China. Electronic address: 
      yangpai0717@163.com.
FAU - Kong, Cong
AU  - Kong C
AD  - Key Laboratory of East China Sea Fishery Resources Exploitation, Ministry of 
      Agriculture and Rural Affairs, East China Sea Fisheries Research Institute, 
      Chinese Academy of Fishery Sciences, Shanghai 200090, China. Electronic address: 
      kongc@ecsf.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20210721
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Biogenic Amines)
SB  - IM
MH  - *Biogenic Amines/analysis/isolation & purification
MH  - *Chromatography, High Pressure Liquid
MH  - *Food Analysis/methods
MH  - *Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Biogenic amines
OT  - HILIC
OT  - High-performance liquid chromatography-tandem mass spectrometry
OT  - Histamine
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/08/02 06:00
MHDA- 2021/10/14 06:00
CRDT- 2021/08/01 20:46
PHST- 2021/04/06 00:00 [received]
PHST- 2021/07/13 00:00 [revised]
PHST- 2021/07/16 00:00 [accepted]
PHST- 2021/08/02 06:00 [pubmed]
PHST- 2021/10/14 06:00 [medline]
PHST- 2021/08/01 20:46 [entrez]
AID - S0021-9673(21)00539-2 [pii]
AID - 10.1016/j.chroma.2021.462415 [doi]
PST - ppublish
SO  - J Chromatogr A. 2021 Sep 13;1653:462415. doi: 10.1016/j.chroma.2021.462415. Epub 
      2021 Jul 21.