PMID- 34333253
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210819
IS  - 2210-2612 (Print)
IS  - 2210-2612 (Electronic)
IS  - 2210-2612 (Linking)
VI  - 85
DP  - 2021 Aug
TI  - Malignant pleural mesothelioma showing rare morphology indistinguishable from 
      myxofibrosarcoma concomitant with EGFR-mutated lung adenocarcinoma: A case 
      report.
PG  - 106237
LID - S2210-2612(21)00739-2 [pii]
LID - 10.1016/j.ijscr.2021.106237 [doi]
LID - 106237
AB  - INTRODUCTION AND IMPORTANCE: Primary tumors of the pleura are rare, with 
      malignant mesothelioma being the most common of these neoplasms. Pathological 
      diagnosis of sarcomatoid mesothelioma can be more challenging than that of 
      epithelioid malignant mesothelioma because of its similarities with true sarcomas 
      and restricted or inconsistent expression of mesothelial markers in 
      immunohistochemistry analysis. PRESENTATION OF CASE: Here, we present an unusual 
      case of malignant pleural mesothelioma concomitant with lung adenocarcinoma in a 
      72-year-old Japanese man, a smoker with no family history of cancer and asbestos 
      exposure. Malignant pleural mesothelioma is composed of epithelial and 
      spindle-shaped cells. Spindle-shaped cells with scant eosinophilic cytoplasm and 
      hyperchromatic nuclei proliferated in abundant myxoid stroma containing 
      thin-walled blood vessels, mimicking myxofibrosarcoma. The loss of BAP1 
      (BRCA1-associated protein 1) expression, as assessed by immunohistochemistry, and 
      homozygous deletions of CDKN2A, detected using fluorescence in situ hybridization 
      (FISH), were observed in both components. Targeted sequencing revealed that lung 
      adenocarcinoma harbored EGFR mutations, whereas no mutations were detected in 
      either component of biphasic mesothelioma. DISCUSSION: Although alcian 
      blue-stained mucins were detected in biphasic mesothelioma subsets, the 
      clinicopathological significance of myxoid stroma in biphasic and sarcomatoid 
      mesothelioma remains largely unknown. CONCLUSION: Our case presented a unique 
      morphology mimicking myxofibrosarcoma in a sarcomatoid component of biphasic 
      mesothelioma; therefore, it raises a question on the clinicopathological 
      significance of myxoid stroma in sarcomatous areas of biphasic and sarcomatoid 
      mesothelioma.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Onagi, Hiroko
AU  - Onagi H
AD  - Department of Human Pathology, Juntendo University Graduate School of Medicine, 
      Bunkyo-ku, Tokyo 113-8421, Japan.
FAU - Hayashi, Takuo
AU  - Hayashi T
AD  - Department of Human Pathology, Juntendo University Graduate School of Medicine, 
      Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address: tkhyz@juntendo.ac.jp.
FAU - Saito, Tsuyoshi
AU  - Saito T
AD  - Department of Human Pathology, Juntendo University Graduate School of Medicine, 
      Bunkyo-ku, Tokyo 113-8421, Japan.
FAU - Kishikawa, Satsuki
AU  - Kishikawa S
AD  - Department of Human Pathology, Juntendo University Graduate School of Medicine, 
      Bunkyo-ku, Tokyo 113-8421, Japan.
FAU - Takamochi, Kazuya
AU  - Takamochi K
AD  - Department of General Thoracic Surgery, Juntendo University School of Medicine, 
      Bunkyo-ku, Tokyo 113-8421, Japan.
FAU - Suzuki, Kenji
AU  - Suzuki K
AD  - Department of General Thoracic Surgery, Juntendo University School of Medicine, 
      Bunkyo-ku, Tokyo 113-8421, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210727
PL  - Netherlands
TA  - Int J Surg Case Rep
JT  - International journal of surgery case reports
JID - 101529872
PMC - PMC8346637
OTO - NOTNLM
OT  - Biphasic subtype
OT  - Homozygous deletions of p16
OT  - Malignant mesothelioma
OT  - Myxofibrosarcoma
COIS- None declared.
EDAT- 2021/08/02 06:00
MHDA- 2021/08/02 06:01
PMCR- 2021/07/27
CRDT- 2021/08/01 20:50
PHST- 2021/06/30 00:00 [received]
PHST- 2021/07/21 00:00 [revised]
PHST- 2021/07/22 00:00 [accepted]
PHST- 2021/08/02 06:00 [pubmed]
PHST- 2021/08/02 06:01 [medline]
PHST- 2021/08/01 20:50 [entrez]
PHST- 2021/07/27 00:00 [pmc-release]
AID - S2210-2612(21)00739-2 [pii]
AID - 106237 [pii]
AID - 10.1016/j.ijscr.2021.106237 [doi]
PST - ppublish
SO  - Int J Surg Case Rep. 2021 Aug;85:106237. doi: 10.1016/j.ijscr.2021.106237. Epub 
      2021 Jul 27.