PMID- 34333669 OWN - NLM STAT- MEDLINE DCOM- 20220406 LR - 20220406 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) VI - 272 IP - 3 DP - 2022 Apr TI - Temporal and time-frequency features of auditory oddball response in distinct subtypes of patients at clinical high risk for psychosis. PG - 449-459 LID - 10.1007/s00406-021-01316-1 [doi] AB - Individuals at clinical high risk (CHR) for psychosis exhibit a reduced P300 oddball response, which indicates deficits in attention and working memory processes. Previous studies have mainly researched these responses in the temporal domain; hence, non-phase-locked or induced neural activities may have been ignored. Event-related potential (ERP) and time-frequency (TF) information, combined with clinical and cognitive profiles, may provide an insight into the pathophysiology and psychopathology of the CHR stage. The 104 CHR individuals who completed cognitive assessments and ERP tests were recruited and followed up between 2016 and 2018. Individuals with CHR were classified by three clinical subtypes demonstrated before, specifically 32 from Cluster-1 (characterized by extensive negative symptoms and cognitive deficits, at the highest risk for conversion to psychosis), 34 from Cluster-2 (characterized by thought and behavioral disorganization, with moderate cognitive impairment), and 38 from Cluster-3 (characterized by the mildest symptoms and cognitive deficits). Electroencephalograms were recorded during the auditory oddball paradigm. The P300 ERPs were analyzed in the temporal domain. The event-related spectral perturbation (ERSP) and inter-trial coherence (ITC) were acquired by TF analysis. A reduced P300 response to target tones was noted in Cluster-1 relative to the other two clusters. Moreover, the P300 amplitude of Cluster-1 was associated with speed of processing (SoP) scores. Furthermore, the P300 amplitude of Cluster-3 was significantly correlated with verbal and visual learning scores. In the TF analysis, decreased delta ERSP and ITC were observed in Cluster-1; delta ITC was associated with SoP scores in Cluster-3. The results indicate relatively disrupted oddball responses in a certain CHR subtype and a close affinity between these electrophysiological indexes and attention, working memory, and declarative memory within different CHR clusters. These findings suggest that the auditory oddball response is a potential neurophysiological marker for distinct clinical subtypes of CHR. CI - (c) 2021. Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Wu, GuiSen AU - Wu G AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Tang, XiaoChen AU - Tang X AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Gan, RanPiao AU - Gan R AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Zeng, JiaHui AU - Zeng J AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Hu, YeGang AU - Hu Y AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Xu, LiHua AU - Xu L AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Wei, YanYan AU - Wei Y AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Tang, YingYing AU - Tang Y AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Chen, Tao AU - Chen T AD - Big Data Research Lab, University of Waterloo, Waterloo, ON, Canada. AD - Senior Research Fellow, Labor and Worklife Program, Harvard University, Cambridge, MA, USA. AD - Niacin (Shanghai) Technology Co., Ltd., Shanghai, People's Republic of China. FAU - Li, ChunBo AU - Li C AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Wang, JiJun AU - Wang J AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. jijunwang27@163.com. AD - Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, People's Republic of China. jijunwang27@163.com. AD - Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai, People's Republic of China. jijunwang27@163.com. AD - Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. jijunwang27@163.com. FAU - Zhang, TianHong AU - Zhang T AUID- ORCID: 0000-0002-5379-7119 AD - Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. zhang_tianhong@126.com. LA - eng GR - 81671329, 81671332, 81901832/National Natural Science Foundation of China/ GR - 19441907800, 19ZR1445200, 17411953100, 19410710800, 19411969100, 19411950800/Science and Technology Commission of Shanghai Municipality/ GR - 19MC1911100/Shanghai Clinical Research Center for Mental Health/ GR - CRC2018ZD01, CRC2018ZD04/The Clinical Research Center at Shanghai Mental Health Center/ GR - GWV-10.1-XK18/Project of the Key Discipline Construction, Shanghai 3-Year Public Health Action Plan/ PT - Journal Article DEP - 20210801 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 SB - IM MH - Acoustic Stimulation/methods MH - *Cognition Disorders MH - Electroencephalography/methods MH - Event-Related Potentials, P300/physiology MH - Evoked Potentials MH - Humans MH - *Psychotic Disorders OTO - NOTNLM OT - Event-related spectral perturbation OT - Inter-trial coherence OT - Neurocognitive OT - P300 oddball OT - Subtypes OT - Ultra-high risk EDAT- 2021/08/02 06:00 MHDA- 2022/04/07 06:00 CRDT- 2021/08/01 21:12 PHST- 2021/05/02 00:00 [received] PHST- 2021/07/26 00:00 [accepted] PHST- 2021/08/02 06:00 [pubmed] PHST- 2022/04/07 06:00 [medline] PHST- 2021/08/01 21:12 [entrez] AID - 10.1007/s00406-021-01316-1 [pii] AID - 10.1007/s00406-021-01316-1 [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2022 Apr;272(3):449-459. doi: 10.1007/s00406-021-01316-1. Epub 2021 Aug 1.