PMID- 34334135
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220328
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 20
IP  - 1
DP  - 2021 Aug 1
TI  - Blood lipid profile changes in type 2 diabetic rats after tail suspension and 
      reloading.
PG  - 84
LID - 10.1186/s12944-021-01511-y [doi]
LID - 84
AB  - PURPOSE: The effects of the tail suspension and reloading on the protein and 
      lipid metabolism in muscle and blood in type 2 diabetes mellitus (T2DM) are 
      unclear. This study evaluated the hypothesis that skeletal muscle catabolism is 
      greater in T2DM than in non-diabetes mellitus (non-DM) rats and that the 
      activity-dependent changes in the intramuscular lipid accumulation and blood 
      lipid profile are poorer in T2DM than in non-DM rats. METHODS: T2DM and non-DM 
      rats were suspended for two weeks followed by reloading for two weeks. The muscle 
      and blood were then examined. RESULTS: In contrast to our hypothesis, there was 
      no marked difference between the T2DM and non-DM groups in terms of the skeletal 
      muscle catabolism and activity-dependent changes in intramuscular lipid 
      accumulation. However, the blood lipid profile increased in the T2DM group 
      compared to the non-DM group. One interesting finding in this study was the 
      decrease in non-high-density lipoprotein (non-HDL) cholesterol levels after one 
      week of reloading followed by a significant increase in the non-HDL cholesterol 
      levels after two weeks of reloading in the T2DM group. CONCLUSION: These results 
      suggest that a dramatic increase in activity after a period of inactivity may 
      rapidly improve the blood lipid profile in T2DM rats.
CI  - (c) 2021. The Author(s).
FAU - Tanaka, Shoji
AU  - Tanaka S
AUID- ORCID: 0000-0002-0289-7320
AD  - Department of Rehabilitation, Faculty of Health Sciences, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, 
      Kanazawa, 920-0942, Japan. tanakas@mhs.mp.kanazawa-u.ac.jp.
FAU - Madokoro, Sachiko
AU  - Madokoro S
AD  - Department of Rehabilitation, Faculty of Health Sciences, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, 
      Kanazawa, 920-0942, Japan.
FAU - Inaoka, Pleiades Tiharu
AU  - Inaoka PT
AD  - Department of Rehabilitation, Faculty of Health Sciences, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, 
      Kanazawa, 920-0942, Japan.
FAU - Yamazaki, Toshiaki
AU  - Yamazaki T
AD  - Department of Rehabilitation, Faculty of Health Sciences, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, 
      Kanazawa, 920-0942, Japan.
LA  - eng
GR  - 18K17713/Grants-in Aid for Scientific Research (JP)/
PT  - Journal Article
DEP - 20210801
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Diabetes Mellitus, Type 2/*blood/psychology
MH  - Hindlimb Suspension/*physiology
MH  - Lipids/*blood
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - Physical Conditioning, Animal/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Triglycerides/blood
PMC - PMC8327430
OTO - NOTNLM
OT  - Blood lipid profile
OT  - Non-high-density lipoprotein cholesterol
OT  - Reloading
OT  - Tail suspension
OT  - Type-2 diabetes mellitus
COIS- None.
EDAT- 2021/08/03 06:00
MHDA- 2022/03/29 06:00
PMCR- 2021/08/01
CRDT- 2021/08/02 05:28
PHST- 2021/05/04 00:00 [received]
PHST- 2021/07/22 00:00 [accepted]
PHST- 2021/08/02 05:28 [entrez]
PHST- 2021/08/03 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/08/01 00:00 [pmc-release]
AID - 10.1186/s12944-021-01511-y [pii]
AID - 1511 [pii]
AID - 10.1186/s12944-021-01511-y [doi]
PST - epublish
SO  - Lipids Health Dis. 2021 Aug 1;20(1):84. doi: 10.1186/s12944-021-01511-y.