PMID- 34334136
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210806
IS  - 2055-0294 (Print)
IS  - 2055-0294 (Electronic)
IS  - 2055-0294 (Linking)
VI  - 7
IP  - 1
DP  - 2021 Aug 2
TI  - Anorexia, pain and peripheral neuropathy are associated with a decrease in 
      quality of life in patients with advanced pancreatic cancer receiving outpatient 
      chemotherapy - a retrospective observational study.
PG  - 27
LID - 10.1186/s40780-021-00210-1 [doi]
LID - 27
AB  - BACKGROUND: Cancer chemotherapy usually improves clinical outcomes in patients 
      with advanced pancreatic cancer (APC), but can also cause moderate-to-severe 
      adverse events (AEs). We investigated the relationship between moderate-to-severe 
      AEs and quality of life (QOL) in patients with APC who received outpatient 
      chemotherapy. METHODS: We recruited APC patients who received outpatient 
      chemotherapy in Gifu University Hospital between September 2017 and December 
      2018. Adverse events related to chemotherapy were assessed by a pharmacist 
      collaborating with a physician using common terminology criteria for AEs (CTCAE) 
      ver 4.0, and QOL of patients was self-assessed by patients using the five-level 
      EuroQol five-dimensional questionnaire (EQ-5D-5L Japanese edition 2). 
      Associations between the EQ-5D-5L utility value and serious AEs were assessed 
      using proportional odds logistic regression. RESULTS: A total of 59 patients who 
      received 475 chemotherapy cycles were included. The proportional odds logistic 
      regression indicated that grade >/= 2 anorexia, pain and peripheral neuropathy were 
      significantly correlated with a decreased EQ-5D-5L utility value. Pharmaceutical 
      intervention for these AEs significantly improved the patients' EQ-5D-5L utility 
      value. CONCLUSIONS: Anorexia, pain and peripheral neuropathy were significantly 
      associated with a decrease in QOL. It is assumed that appropriate pharmaceutical 
      intervention with particular emphasis on these AEs can improve the QOL of 
      pancreatic cancer patients receiving outpatient chemotherapy.
CI  - (c) 2021. The Author(s).
FAU - Fujii, Hironori
AU  - Fujii H
AD  - Department of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, 
      Japan. h_fujii@gifu-u.ac.jp.
FAU - Koda, Maaya
AU  - Koda M
AD  - Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical 
      University, Gifu, 501-1196, Japan.
FAU - Sadaka, Shiori
AU  - Sadaka S
AD  - Department of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, 
      Japan.
FAU - Ohata, Koichi
AU  - Ohata K
AD  - Department of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, 
      Japan.
FAU - Kato-Hayashi, Hiroko
AU  - Kato-Hayashi H
AD  - Department of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, 
      Japan.
FAU - Iihara, Hirotoshi
AU  - Iihara H
AD  - Department of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, 
      Japan.
FAU - Kobayashi, Ryo
AU  - Kobayashi R
AD  - Department of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, 
      Japan.
FAU - Ishihara, Takuma
AU  - Ishihara T
AD  - Gifu University Hospital, Innovative and Clinical Research Promotion Center, Gifu 
      University, Gifu, 501-1194, Japan.
FAU - Uemura, Shinya
AU  - Uemura S
AD  - First Department of Internal Medicine, Gifu University Hospital, Gifu, 501-1194, 
      Japan.
FAU - Iwashita, Takuji
AU  - Iwashita T
AD  - First Department of Internal Medicine, Gifu University Hospital, Gifu, 501-1194, 
      Japan.
FAU - Hayashi, Hideki
AU  - Hayashi H
AD  - Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical 
      University, Gifu, 501-1196, Japan.
FAU - Sugiyama, Tadashi
AU  - Sugiyama T
AD  - Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical 
      University, Gifu, 501-1196, Japan.
FAU - Shimizu, Masahito
AU  - Shimizu M
AD  - First Department of Internal Medicine, Gifu University Hospital, Gifu, 501-1194, 
      Japan.
FAU - Suzuki, Akio
AU  - Suzuki A
AD  - Department of Pharmacy, Gifu University Hospital, Yanagido 1-1, Gifu, 501-1194, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20210802
PL  - England
TA  - J Pharm Health Care Sci
JT  - Journal of pharmaceutical health care and sciences
JID - 101672177
PMC - PMC8327438
OTO - NOTNLM
OT  - Adverse events related outpatient cancer chemotherapy
OT  - Pancreatic cancer
OT  - Proportional odds logistic regression model
OT  - Quality of life
OT  - Retrospective observational study
COIS- Not applicable.
EDAT- 2021/08/03 06:00
MHDA- 2021/08/03 06:01
PMCR- 2021/08/02
CRDT- 2021/08/02 05:28
PHST- 2020/11/26 00:00 [received]
PHST- 2021/05/18 00:00 [accepted]
PHST- 2021/08/02 05:28 [entrez]
PHST- 2021/08/03 06:00 [pubmed]
PHST- 2021/08/03 06:01 [medline]
PHST- 2021/08/02 00:00 [pmc-release]
AID - 10.1186/s40780-021-00210-1 [pii]
AID - 210 [pii]
AID - 10.1186/s40780-021-00210-1 [doi]
PST - epublish
SO  - J Pharm Health Care Sci. 2021 Aug 2;7(1):27. doi: 10.1186/s40780-021-00210-1.