PMID- 34335172
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Changes in Resting-State Spontaneous Brain Activity in Patients With Allergic 
      Rhinitis: A Pilot Neuroimaging Study.
PG  - 697299
LID - 10.3389/fnins.2021.697299 [doi]
LID - 697299
AB  - BACKGROUND: Allergic rhinitis (AR) is an inflammatory disorder of the nose caused 
      by immunoglobulin E (IgE)-mediated immune response to allergens. Apart from the 
      typical symptoms of sneezing, itching, rhinorrhea, and nasal congestion, 
      behavioral complications were also reported to be associated with the progression 
      of AR, such as cognitive deficits, mood changes, memory decline, attention 
      deficiency, poor school performance, anxiety, and depression. Recent human 
      studies have suggested that alterations in brain function caused by allergen 
      exposure may precipitate high levels of anxiety and emotional reactivity in 
      asthma patients. But until now, there is no direct evidence of the relationship 
      between brain activity and allergic rhinitis. METHODS: Resting-state functional 
      magnetic resonance imaging (rs-fMRI) was used to excavate whether there remain 
      functional changes of brain activity in AR patients. We measured the amplitude of 
      low-frequency fluctuation (ALFF) and the z conversion of ALFF (zALFF) in 20 
      patients with AR and 20 age- and sex-matched healthy controls (HCs) using the 
      rs-fMRI data. RESULTS: Compared with healthy controls, AR patients exhibited 
      lower ALFF values in the precuneus (PCUN) and higher ALFF values in the anterior 
      cingulate cortex (ACC). The ALFF values of these features were significantly 
      correlated with the visual analog scale (VAS) scores, the Rhinoconjunctivitis 
      Quality of Life Questionnaire (RQLQ) scores, the subscales of RQLQ, and specific 
      IgE, partly. CONCLUSION: We found changes in resting-state spontaneous brain 
      activity in AR patients with hypoactivity in the PCUN and hyperactivity of the 
      ACC. The brain-related symptoms of AR might be another potential clinical 
      intervention target for improving the life quality of AR patients. Further 
      attention to brain activity is essential for a deeper understanding of AR.
CI  - Copyright (c) 2021 Gao, Chen, Xiang, Zhang, Tan, Fan, Liu, Lv and Xu.
FAU - Gao, Ziang
AU  - Gao Z
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Chen, Xixiang
AU  - Chen X
AD  - Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Xiang, Rong
AU  - Xiang R
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Tan, Lu
AU  - Tan L
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Fan, Wenjun
AU  - Fan W
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Liu, Peiqiang
AU  - Liu P
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Lv, Hao
AU  - Lv H
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Xu, Yu
AU  - Xu Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, China.
LA  - eng
PT  - Journal Article
DEP - 20210714
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8317644
OTO - NOTNLM
OT  - allergic rhinitis
OT  - anterior cingulate cortex
OT  - cognition
OT  - memory
OT  - neuroimaging
OT  - precuneus
OT  - resting-state fMRI
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/03 06:00
MHDA- 2021/08/03 06:01
PMCR- 2021/01/01
CRDT- 2021/08/02 05:53
PHST- 2021/04/19 00:00 [received]
PHST- 2021/06/08 00:00 [accepted]
PHST- 2021/08/02 05:53 [entrez]
PHST- 2021/08/03 06:00 [pubmed]
PHST- 2021/08/03 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.697299 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Jul 14;15:697299. doi: 10.3389/fnins.2021.697299. 
      eCollection 2021.