PMID- 34335232
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210803
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 13
DP  - 2021
TI  - Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor: A 2-Year 
      Outcome Study of Chinese People.
PG  - 697029
LID - 10.3389/fnagi.2021.697029 [doi]
LID - 697029
AB  - Background: Essential tremor (ET) is a common movement disorder among elderly 
      individuals worldwide and is occasionally associated with a high risk for mild 
      cognitive impairment and dementia. This retrospective study aimed to determine 
      the clinical outcome of unilateral magnetic resonance-guided focused ultrasound 
      (MRgFUS) thalamotomy in Chinese patients with ET. Methods: In total, 31 male and 
      17 female patients with drug-refractory ET were enrolled in this research study 
      from January 2017 to September 2019. The severity of tremor and disability were 
      assessed using the Clinical Rating Scale for Tremor (CRST) within a 2-year 
      follow-up period. Results: The mean age of the participants was 59.14 +/- 13.5 
      years. The mean skull density ratio (SDR) was 0.5 +/- 0.1. The mean highest 
      temperature was 57.0 +/- 2.4 degrees C. The mean number of sonications was 10.0 +/- 2.6. The 
      average maximum energy was 19,710.5 +/- 8,624.9 J. The total CRST scores and 
      sub-scores after MRgFUS thalamotomy significantly reduced during each follow-up 
      (p < 0.001). All but four (8.3%) of the patients had reversible adverse events 
      (AEs) after the procedure. Conclusions: MRgFUS had sustained clinical efficacy 2 
      years after treatment for intractable ET. Only few patients presented with 
      thalamotomy-related AEs including numbness, weakness, and ataxia for an extended 
      period. Most Chinese patients were treated safely and effectively despite their 
      low SDR.
CI  - Copyright (c) 2021 Wu, Lin, Li, Lai, Lee, Tsai, Chiu, Chang, Wei and Taira.
FAU - Wu, Peihan
AU  - Wu P
AD  - Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua 
      County, Taiwan.
FAU - Lin, Wei
AU  - Lin W
AD  - Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua 
      County, Taiwan.
FAU - Li, Kun Hong
AU  - Li KH
AD  - MR-Guided Focused Ultrasound Center, Chang Bing Show Chwan Memorial Hospital, 
      Changhua County, Taiwan.
FAU - Lai, Hui-Chin
AU  - Lai HC
AD  - MR-Guided Focused Ultrasound Center, Chang Bing Show Chwan Memorial Hospital, 
      Changhua County, Taiwan.
FAU - Lee, Ming-Tsung
AU  - Lee MT
AD  - Research Assistant Center, Show Chwan Memorial Hospital, Changhua, Taiwan.
AD  - Department of Nursing, Hungkuang University, Taichung, Taiwan.
FAU - Tsai, Kevin Wen-Kai
AU  - Tsai KW
AD  - InSightec Ltd., Tirat Carmel, Israel.
FAU - Chiu, Pai-Yi
AU  - Chiu PY
AD  - Department of Neurology, Show Chwan Memorial Hospital, Changhua, Taiwan.
FAU - Chang, Wei-Chieh
AU  - Chang WC
AD  - Department of Neurosurgery, Chang Bing Show Chwan Memorial Hospital, Changhua 
      County, Taiwan.
FAU - Wei, Cheng-Yu
AU  - Wei CY
AD  - Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua 
      County, Taiwan.
AD  - Department of Exercise and Health Promotion, College of Kinesiology and Health, 
      Chinese Culture University, Taipei, Taiwan.
FAU - Taira, Takaomi
AU  - Taira T
AD  - Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210714
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC8317688
OTO - NOTNLM
OT  - MR-guided focused ultrasound
OT  - essential tremor
OT  - focused ultrasound
OT  - functional neurosurgery
OT  - thalamotomy
COIS- KW-KT was employed by company Insightec Ltd. The authors declare that part of 
      this study received funding from Insightec Ltd. under the ET002J protocol. The 
      funder had involvement with the preparation of the manuscript.
EDAT- 2021/08/03 06:00
MHDA- 2021/08/03 06:01
PMCR- 2021/01/01
CRDT- 2021/08/02 05:54
PHST- 2021/04/18 00:00 [received]
PHST- 2021/06/15 00:00 [accepted]
PHST- 2021/08/02 05:54 [entrez]
PHST- 2021/08/03 06:00 [pubmed]
PHST- 2021/08/03 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2021.697029 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2021 Jul 14;13:697029. doi: 10.3389/fnagi.2021.697029. 
      eCollection 2021.