PMID- 34337168
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2405-6324 (Electronic)
IS  - 2405-6324 (Linking)
VI  - 19
DP  - 2021 Sep
TI  - Harmonization of breast cancer radiotherapy treatment planning in the 
      Netherlands.
PG  - 26-32
LID - 10.1016/j.tipsro.2021.06.004 [doi]
AB  - PURPOSE: The aim was to reach consensus in The Netherlands on which parameters 
      should be used to evaluate breast cancer radiotherapy (RT) plans. MATERIALS AND 
      METHODS: A Benchmark Case with delineated planning target volumes (PTVs) and 
      Organs At Risk (OARs) was sent to all Dutch radiotherapy centres in combination 
      with a questionnaire, with the request to generate RT plans prescribing 15 times 
      2.67 Gy for four different treatment indications according to the institutional 
      irradiation technique. The plans and accompanying questionnaire answers were 
      analysed using descriptive statistics. These results, together with a 
      harmonisation proposal, were sent to all centres. The proposal was discussed at a 
      meeting of the Dutch Society of Radiation Oncology breast cancer platform. 
      Distinct parameters were accepted if consensus on them was reached. RESULTS: 19 
      out of 20 Dutch departments participated in this study. PTV coverage varied 
      considerably, with D98% between 63% and 99% for the breast and between 37% and 
      97% for the internal mammary nodes (IMN). Also substantial OAR dose differences 
      were observed, with e.g. mean heart doses ranging between 1.85 Gy and 5.42 Gy in 
      case the IMN were included in the PTV. For evaluation of the PTVs D98%, D2% and 
      Dmean were chosen to report on, with target values of >/= 95% (90% for the 
      PTV_IMN), </= 107%, and 99-101%, respectively. For OARs, consensus was reached on 
      the parameters to be evaluated, without target values: Dmean of the heart, Dmean 
      and V5% of the lungs, and in case of periclavicular radiotherapy V30Gy of the 
      thyroid gland. For patients younger than 40 years a contralateral mean breast 
      dose of </= 1 Gy was agreed upon. CONCLUSION: A new Dutch consensus guideline for 
      evaluation of breast cancer RT plans has been established.
CI  - (c) 2021 The Author(s).
FAU - Hurkmans, Coen
AU  - Hurkmans C
AD  - Department of Radiation Oncology, Catharina Hospital Eindhoven, the Netherlands.
FAU - Duisters, Cindy
AU  - Duisters C
AD  - Department of Radiation Oncology, Catharina Hospital Eindhoven, the Netherlands.
FAU - Peters-Verhoeven, Mieke
AU  - Peters-Verhoeven M
AD  - Department of Radiation Oncology, Catharina Hospital Eindhoven, the Netherlands.
FAU - Boersma, Liesbeth
AU  - Boersma L
AD  - Maastricht University Medical Centre+, Dept. of Radiation Oncology (Maastro), 
      GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands.
FAU - Verhoeven, Karolien
AU  - Verhoeven K
AD  - Maastricht University Medical Centre+, Dept. of Radiation Oncology (Maastro), 
      GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands.
FAU - Bijker, Nina
AU  - Bijker N
AD  - Department of Radiation Oncology, Amsterdam UMC, the Netherlands.
FAU - Crama, Koen
AU  - Crama K
AD  - Department of Radiation Oncology, Amsterdam UMC, the Netherlands.
FAU - Nuver, Tonnis
AU  - Nuver T
AD  - Radiotherapiegroep, the Netherlands.
FAU - van der Sangen, Maurice
AU  - van der Sangen M
AD  - Department of Radiation Oncology, Catharina Hospital Eindhoven, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20210715
PL  - England
TA  - Tech Innov Patient Support Radiat Oncol
JT  - Technical innovations & patient support in radiation oncology
JID - 101762366
EIN - Tech Innov Patient Support Radiat Oncol. 2023 Jan 07;25:100196. PMID: 36659912
PMC - PMC8313838
OTO - NOTNLM
OT  - Breast cancer
OT  - Consensus
OT  - Guideline
OT  - National
OT  - Radiotherapy
OT  - Treatment planning
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/08/03 06:00
MHDA- 2021/08/03 06:01
PMCR- 2021/07/15
CRDT- 2021/08/02 06:11
PHST- 2021/06/22 00:00 [received]
PHST- 2021/06/29 00:00 [revised]
PHST- 2021/06/30 00:00 [accepted]
PHST- 2021/08/02 06:11 [entrez]
PHST- 2021/08/03 06:00 [pubmed]
PHST- 2021/08/03 06:01 [medline]
PHST- 2021/07/15 00:00 [pmc-release]
AID - S2405-6324(21)00027-5 [pii]
AID - 10.1016/j.tipsro.2021.06.004 [doi]
PST - epublish
SO  - Tech Innov Patient Support Radiat Oncol. 2021 Jul 15;19:26-32. doi: 
      10.1016/j.tipsro.2021.06.004. eCollection 2021 Sep.