PMID- 34337826
OWN - NLM
STAT- MEDLINE
DCOM- 20230207
LR  - 20230207
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 29
IP  - 2
DP  - 2023 Mar
TI  - Identification of competing endogenous RNA network in laryngeal squamous cell 
      carcinoma.
PG  - 574-583
LID - 10.1111/odi.13983 [doi]
AB  - OBJECTIVE: This study was conducted to investigate key long noncoding RNAs 
      (lncRNAs) involved in competitive endogenous RNA (ceRNA) network associated with 
      laryngeal squamous cell carcinoma (LSCC). MATERIALS AND METHODS: Three mRNA 
      datasets, two miRNA datasets, and one lncRNA dataset of LSCC were downloaded from 
      GEO database. Following the identification of differentially expressed mRNAs 
      (DEmRNAs), (microRNAs) miRNAs (DEmiRNAs), and lncRNAs (DElncRNAs) in LSCC 
      compared with adjacent tissues, functional enrichment of DEmRNAs was performed. 
      Then, construction of the ceRNA (DElncRNA-DEmiRNA-DEmRNA) regulatory network and 
      functional analyses of all DEmRNAs in ceRNA regulatory network were conducted. 
      Quantitative real-time polymerase chain reactions (qRT-PCR) were used to detect 
      the expression levels of selected DEmRNAs, DEmiRNAs, and DElncRNAs. RESULTS: A 
      total of 3449 DEmRNAs, 40 DEmiRNAs, and 100 DElncRNAs were identified in LSCC. 
      The ceRNA networks, which contained 132 DElncRNA-DEmiRNA pairs and 287 
      DEmiRNA-DEmRNA pairs, involving 44 lncRNAs, 3 miRNAs, and 271 mRNAs, were 
      obtained. DEmRNAs in ceRNA regulatory networks were significantly enriched in 
      pathways in cancer, prostate cancer, and aldosterone-regulated sodium 
      reabsorption. Except for HCG22 and hsa-miR-1246, expressions of the others in the 
      qRT-PCR results played the same pattern with that in our integrated analysis, 
      generally. CONCLUSIONS: We concluded that HCG22/EGOT-hsa-miR-1275-FAM107A and 
      HCG22/EGOT-hsa-miR-1246-Glycerol-3-phosphate dehydrogenase 1 like interaction 
      pairs may play a central role in LSCC.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Cui, Xiao-Feng
AU  - Cui XF
AD  - Shenzhen Key Laboratory of Viral Oncology, Shenzhen, China.
AD  - Department of Otolaryngology, Shenzhen Hospital, Southern Medical University, 
      Shenzhen, China.
FAU - Zhang, Si-Lin
AU  - Zhang SL
AD  - Department of Otolaryngology, Shenzhen Hospital, Southern Medical University, 
      Shenzhen, China.
FAU - Wang, Wei-Ping
AU  - Wang WP
AD  - Department of Otolaryngology, Shenzhen Hospital, Southern Medical University, 
      Shenzhen, China.
FAU - Huang, Xiao-Wu
AU  - Huang XW
AD  - Department of Otolaryngology, Shenzhen Hospital, Southern Medical University, 
      Shenzhen, China.
FAU - Chen, Xiang-Jun
AU  - Chen XJ
AUID- ORCID: 0000-0002-3198-3236
AD  - Department of Otolaryngology, Shenzhen Hospital, Southern Medical University, 
      Shenzhen, China.
LA  - eng
GR  - ZDSYS201707311140430/Shenzhen Key Laboratory of Viral Oncology/
PT  - Journal Article
DEP - 20210812
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
RN  - 0 (MIRN1275 microRNA, human)
MH  - Male
MH  - Humans
MH  - Squamous Cell Carcinoma of Head and Neck/genetics
MH  - *RNA, Long Noncoding/genetics
MH  - Gene Regulatory Networks
MH  - *MicroRNAs/genetics/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - *Head and Neck Neoplasms/genetics
MH  - Gene Expression Regulation, Neoplastic/genetics
OTO - NOTNLM
OT  - GEO
OT  - ceRNA network
OT  - laryngeal squamous cell carcinoma (LSCC)
OT  - long noncoding RNA (lncRNA)
EDAT- 2021/08/03 06:00
MHDA- 2023/02/08 06:00
CRDT- 2021/08/02 06:30
PHST- 2021/06/29 00:00 [revised]
PHST- 2021/04/15 00:00 [received]
PHST- 2021/07/27 00:00 [accepted]
PHST- 2021/08/03 06:00 [pubmed]
PHST- 2023/02/08 06:00 [medline]
PHST- 2021/08/02 06:30 [entrez]
AID - 10.1111/odi.13983 [doi]
PST - ppublish
SO  - Oral Dis. 2023 Mar;29(2):574-583. doi: 10.1111/odi.13983. Epub 2021 Aug 12.