PMID- 34340304
OWN - NLM
STAT- MEDLINE
DCOM- 20210812
LR  - 20221207
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 69
IP  - 31
DP  - 2021 Aug 11
TI  - Lactobacillus rhamnosus LRa05 Ameliorate Hyperglycemia through a Regulating 
      Glucagon-Mediated Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice.
PG  - 8797-8806
LID - 10.1021/acs.jafc.1c02925 [doi]
AB  - In this study, we aimed to explore the antidiabetic effects of Lactobacillus 
      rhamnosus LRa05 on glucose metabolism and gut microbiota in type 2 diabetes 
      mellitus (T2DM) mice. Our data indicated that the fasting blood glucose levels 
      were reduced by 53.5% after treatment with LRa05 at a dose of 10(9) CFU.day(-1). 
      Meanwhile, LRa05 attenuated insulin resistance, relieved hepatic oxidative 
      stress, and alleviated metabolic lipopolysaccharide-related inflammation in T2DM 
      mice. LRa05 promoted the expression of glucose transporter 2, while it inhibited 
      the expression of glucagon receptor, glucose-6-phosphatase, cellular 
      adenosine-3'-5'-cyclic monophosphate-dependent protein kinase, and 
      phosphoenolpyruvate carboxykinase in diabetic mice. Meanwhile, LRa05 reshaped gut 
      microbiota, resulting in increased short-chain fatty acid bacteria 
      (Alloprevotella and Bacteroides) and decreased proinflammatory bacteria 
      (Odoribacter and Mucispirillum). Thus, LRa05 may be used as a functional food 
      supplement for modulating the disorder glucose metabolism and gut microbiota in 
      T2DM.
FAU - Wu, Tao
AU  - Wu T
AUID- ORCID: 0000-0003-1158-4008
AD  - State Key Laboratory of Food Nutrition and Safety, Ministry of Education & 
      Tianjin Key Laboratory of Food Nutrition and Safety, Food Biotechnology 
      Engineering Research Center of Ministry of Education, Tianjin University of 
      Science & Technology, Tianjin 300457, China.
FAU - Zhang, Yongli
AU  - Zhang Y
AD  - State Key Laboratory of Food Nutrition and Safety, Ministry of Education & 
      Tianjin Key Laboratory of Food Nutrition and Safety, Food Biotechnology 
      Engineering Research Center of Ministry of Education, Tianjin University of 
      Science & Technology, Tianjin 300457, China.
FAU - Li, Wen
AU  - Li W
AD  - State Key Laboratory of Food Nutrition and Safety, Ministry of Education & 
      Tianjin Key Laboratory of Food Nutrition and Safety, Food Biotechnology 
      Engineering Research Center of Ministry of Education, Tianjin University of 
      Science & Technology, Tianjin 300457, China.
FAU - Zhao, Yunjiao
AU  - Zhao Y
AD  - State Key Laboratory of Food Nutrition and Safety, Ministry of Education & 
      Tianjin Key Laboratory of Food Nutrition and Safety, Food Biotechnology 
      Engineering Research Center of Ministry of Education, Tianjin University of 
      Science & Technology, Tianjin 300457, China.
FAU - Long, Hairong
AU  - Long H
AD  - State Key Laboratory of Food Nutrition and Safety, Ministry of Education & 
      Tianjin Key Laboratory of Food Nutrition and Safety, Food Biotechnology 
      Engineering Research Center of Ministry of Education, Tianjin University of 
      Science & Technology, Tianjin 300457, China.
AD  - Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi 530023, China.
FAU - Muhindo, Esther Mwizerwa
AU  - Muhindo EM
AD  - Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi 530023, China.
FAU - Liu, Rui
AU  - Liu R
AD  - State Key Laboratory of Food Nutrition and Safety, Ministry of Education & 
      Tianjin Key Laboratory of Food Nutrition and Safety, Food Biotechnology 
      Engineering Research Center of Ministry of Education, Tianjin University of 
      Science & Technology, Tianjin 300457, China.
FAU - Sui, Wenjie
AU  - Sui W
AD  - State Key Laboratory of Food Nutrition and Safety, Ministry of Education & 
      Tianjin Key Laboratory of Food Nutrition and Safety, Food Biotechnology 
      Engineering Research Center of Ministry of Education, Tianjin University of 
      Science & Technology, Tianjin 300457, China.
FAU - Li, Qian
AU  - Li Q
AD  - Tianjin Agricultural University, Tianjin 300384, China.
FAU - Zhang, Min
AU  - Zhang M
AD  - State Key Laboratory of Food Nutrition and Safety, Ministry of Education & 
      Tianjin Key Laboratory of Food Nutrition and Safety, Food Biotechnology 
      Engineering Research Center of Ministry of Education, Tianjin University of 
      Science & Technology, Tianjin 300457, China.
AD  - Tianjin Agricultural University, Tianjin 300384, China.
LA  - eng
PT  - Journal Article
DEP - 20210802
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Blood Glucose)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Experimental
MH  - *Diabetes Mellitus, Type 2
MH  - *Gastrointestinal Microbiome
MH  - Glucagon
MH  - *Hyperglycemia
MH  - *Lacticaseibacillus rhamnosus
MH  - Mice
MH  - Signal Transduction
OTO - NOTNLM
OT  - Lactobacillus rhamnosus LRa05
OT  - T2DM
OT  - anti-hyperglycemic
OT  - glucagon signaling pathway
OT  - gut microbiota
EDAT- 2021/08/04 06:00
MHDA- 2021/08/13 06:00
CRDT- 2021/08/03 05:27
PHST- 2021/08/04 06:00 [pubmed]
PHST- 2021/08/13 06:00 [medline]
PHST- 2021/08/03 05:27 [entrez]
AID - 10.1021/acs.jafc.1c02925 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2021 Aug 11;69(31):8797-8806. doi: 10.1021/acs.jafc.1c02925. 
      Epub 2021 Aug 2.