PMID- 34344069
OWN - NLM
STAT- MEDLINE
DCOM- 20210805
LR  - 20210805
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 50
IP  - 8
DP  - 2021 Aug 8
TI  - [Mesenchymal chondrosarcoma in central nervous system: a clinicopathological 
      analysis].
PG  - 870-875
LID - 10.3760/cma.j.cn112151-20210302-00176 [doi]
AB  - Objective: To investigate the clinicopathological features of central nervous 
      system (CNS) mesenchymal chondrosarcoma (MCS). Methods: Nine cases of CNS MCS 
      were collected at the First Affiliated Hospital of Fujian Medical University from 
      September 2010 to September 2020. The clinical,imaging,histopathological and 
      immunohistochemical features were reviewed. NCOA2 gene rearrangement was 
      evaluated by fluorescence in situ hybridization (FISH). Results: There were three 
      male and six female patients, with age range of 1 to 59 years (median 31 years). 
      Six cases were intracranial and three cases were intraspinal, and the tumors 
      showed dural attachment. They were often diagnosed as meningioma basing on 
      preoperative imaging. Microscopically, the tumors showed a characteristic 
      biphasic histologic pattern composed of undifferentiated mesenchymal small cells 
      and well-differentiated hyaline cartilage islands. The small cells area were 
      positive for SOX9 (9/9), CD99 (8/9), and without BRG1 and INI1 deletion. The 
      cartilaginous component expressed SOX9 (9/9) and S-100 protein (8/9). NCOA2 gene 
      break apart signal was identified in five cases (5/5). Eight patients were 
      followed up for 4-124 months. Three patients (3/8) had recurrences within one 
      year and two patients died of the tumor. Conclusions: CNS MCS is an extremely 
      rare malignant neoplasm with a propensity to dural involvement. Preoperative 
      imaging has low diagnostic accuracy. CNS MCS should be differentiated from other 
      CNS small round cell tumors and chondrosarcoma. FISH detection of NCOA2 gene 
      rearrangement will assist the diagnosis of MCS.
FAU - Huang, Q
AU  - Huang Q
AD  - Department of Pathology, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou 350005, China.
FAU - Chen, Y P
AU  - Chen YP
AD  - Department of Pathology, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou 350005, China.
FAU - Song, F L
AU  - Song FL
AD  - Department of Pathology, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou 350005, China.
FAU - Zheng, L M
AU  - Zheng LM
AD  - Department of Pathology, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou 350005, China.
FAU - Liu, X Y
AU  - Liu XY
AD  - Department of Pathology, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou 350005, China.
FAU - Zhang, S
AU  - Zhang S
AD  - Department of Pathology, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou 350005, China.
FAU - Wang, X F
AU  - Wang XF
AD  - Department of Pathology, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou 350005, China.
LA  - chi
GR  - 2018J01155/Natural Science Foundation of Fujian Province/
GR  - FBJG20170072/Funds of Fujian Provincial Research Project on the Reform of 
      Undergraduate Education and Teaching/
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Bone Neoplasms/diagnostic imaging/genetics
MH  - Central Nervous System
MH  - Child
MH  - Child, Preschool
MH  - *Chondrosarcoma/diagnostic imaging/genetics/surgery
MH  - *Chondrosarcoma, Mesenchymal/diagnostic imaging/genetics/surgery
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2021/08/04 06:00
MHDA- 2021/08/06 06:00
CRDT- 2021/08/03 23:10
PHST- 2021/08/03 23:10 [entrez]
PHST- 2021/08/04 06:00 [pubmed]
PHST- 2021/08/06 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20210302-00176 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2021 Aug 8;50(8):870-875. doi: 
      10.3760/cma.j.cn112151-20210302-00176.