PMID- 34345271
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210806
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Print)
IS  - 1792-0981 (Linking)
VI  - 22
IP  - 3
DP  - 2021 Sep
TI  - Systemic immune-inflammation index predicts a reduced risk of end-stage renal 
      disease in Chinese patients with myeloperoxidase-anti-neutrophil cytoplasmic 
      antibody-associated vasculitis: A retrospective observational study.
PG  - 989
LID - 10.3892/etm.2021.10421 [doi]
LID - 989
AB  - Chronic inflammation has been indicated to be important in the pathogenesis of 
      anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). The systemic 
      immune-inflammation index (SII) is a novel marker of inflammation. The present 
      study was thus performed to explore the association between the SII at diagnosis 
      and inflammatory response and disease activity in Chinese patients with 
      myeloperoxidase (MPO)-AAV. Furthermore, it was evaluated whether the SII is able 
      to predict the progression to end-stage renal disease (ESRD) and patient 
      survival. A total of 190 patients with MPO-AAV were included in the present 
      study. The baseline SII was positively correlated with C-reactive protein (CRP; 
      r=0.274, P<0.0001) and the erythrocyte sedimentation rate (ESR; r=0.481, 
      P<0.0001). However, the SII had no obvious correlation with the Birmingham 
      vasculitis activity score. Patients with SII>/=2,136.45 exhibited better cumulative 
      renal survival rates than those with SII<2,136.45 (P=0.001). However, no 
      significant difference in patient survival was indicated between patients with 
      SII>/=2,136.45 and those with SII<2,136.45 at diagnosis. In conclusion, the SII was 
      positively correlated with CRP and ESR in Chinese patients with MPO-AAV. 
      Furthermore, the SII may be an independent factor associated with a reduced risk 
      of ESRD.
CI  - Copyright: (c) Chen et al.
FAU - Chen, Jin-Biao
AU  - Chen JB
AD  - Department of Medical Records & Information, Xiangya Hospital, Central South 
      University, Changsha, Hunan 410008, P.R. China.
FAU - Tang, Rong
AU  - Tang R
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Zhong, Yong
AU  - Zhong Y
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Zhou, Ya-Ou
AU  - Zhou YO
AD  - Department of Rheumatology and Immunology, Xiangya Hospital, Central South 
      University, Changsha, Hunan 410008, P.R. China.
FAU - Zuo, Xiaoxia
AU  - Zuo X
AD  - Department of Rheumatology and Immunology, Xiangya Hospital, Central South 
      University, Changsha, Hunan 410008, P.R. China.
FAU - Luo, Hui
AU  - Luo H
AD  - Department of Rheumatology and Immunology, Xiangya Hospital, Central South 
      University, Changsha, Hunan 410008, P.R. China.
FAU - Huang, Li
AU  - Huang L
AD  - Department of Critical Care Medicine, Xiangya Hospital, Central South University, 
      Changsha, Hunan 410008, P.R. China.
FAU - Lin, Wei
AU  - Lin W
AD  - Department of Pathology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Wu, Ting
AU  - Wu T
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Yang, Yingqiang
AU  - Yang Y
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Meng, Ting
AU  - Meng T
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Xiao, Zhou
AU  - Xiao Z
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Ao, Xiang
AU  - Ao X
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Xiao, Xiangcheng
AU  - Xiao X
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Zhou, Qiaoling
AU  - Zhou Q
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Xiao, Ping
AU  - Xiao P
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20210713
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC8311255
OTO - NOTNLM
OT  - anti-neutrophil cytoplasmic antibody-associated vasculitis
OT  - end-stage renal disease
OT  - mortality
OT  - myeloperoxidase
OT  - systemic immune-inflammation index
COIS- The authors declare that they have no competing interests.
EDAT- 2021/08/05 06:00
MHDA- 2021/08/05 06:01
PMCR- 2021/07/13
CRDT- 2021/08/04 07:06
PHST- 2019/07/26 00:00 [received]
PHST- 2021/01/15 00:00 [accepted]
PHST- 2021/08/04 07:06 [entrez]
PHST- 2021/08/05 06:00 [pubmed]
PHST- 2021/08/05 06:01 [medline]
PHST- 2021/07/13 00:00 [pmc-release]
AID - ETM-0-0-10421 [pii]
AID - 10.3892/etm.2021.10421 [doi]
PST - ppublish
SO  - Exp Ther Med. 2021 Sep;22(3):989. doi: 10.3892/etm.2021.10421. Epub 2021 Jul 13.