PMID- 34348314
OWN - NLM
STAT- MEDLINE
DCOM- 20220119
LR  - 20220216
IS  - 1423-0100 (Electronic)
IS  - 0300-5526 (Print)
IS  - 0300-5526 (Linking)
VI  - 65
IP  - 1
DP  - 2022
TI  - Human Herpesvirus 6 Infection and Risk of Chronic Fatigue Syndrome: A Systematic 
      Review and Meta-Analysis.
PG  - 49-57
LID - 10.1159/000517930 [doi]
AB  - INTRODUCTION: Chronic fatigue syndrome (CFS) is a neurological disease that is 
      accompanied by excessive fatigue or tiredness. There are several reports 
      confirming the association between human herpesvirus 6 (HHV-6) infection and CFS 
      illness. This systematic review and meta-analysis was performed to integrate the 
      information of published studies with regard to this association until May 2021. 
      METHODS: The literature search was based on keywords including "chronic fatigue 
      syndrome and HHV 6," "chronic fatigue syndrome and HHV-6," "chronic fatigue 
      syndrome and HHV6," "chronic fatigue syndrome and Herpes virus 6," and "chronic 
      fatigue syndrome and Herpesvirus6" in MEDLINE (PubMed), Web of Science, and 
      EMBASE. RESULTS: The literature search identified 17 studies to be included in 
      the systematic review and 11 studies in meta-analysis. The symmetry funnel plot 
      and Egger's test (p value = 0.2) identified no publication bias among studies. 
      Moreover, the low level of I2 revealed homogeneity across studies. DISCUSSION: In 
      conclusion, the association between the HHV-6 infection and CFS incidence was 
      substantiated. However, the results of this study also suggest that further 
      comprehensive studies are needed to solidify the association between HHV-6 and 
      CFS. Future studies should consider additional factors that may have affected the 
      significance of such a correlation.
CI  - (c) 2021 The Author(s) Published by S. Karger AG, Basel.
FAU - Mozhgani, Sayed-Hamidreza
AU  - Mozhgani SH
AD  - Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, 
      Karaj, Iran.
AD  - Department of Microbiology, Faculty of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Rajabi, Farid
AU  - Rajabi F
AD  - Department of Virology, School of Public Health, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Qurbani, Mohsen
AU  - Qurbani M
AD  - Department of Virology, School of Public Health, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Erfani, Yousef
AU  - Erfani Y
AD  - Department of Medical Laboratory Sciences, School of Allied Medical Sciences, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Yaslianifard, Somayeh
AU  - Yaslianifard S
AD  - Department of Microbiology, Faculty of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
AD  - Dietary Supplements and Probiotic Research Center, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Moosavi, Azam
AU  - Moosavi A
AD  - Department of Biochemistry, Faculty of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Pourrostami, Kiomars
AU  - Pourrostami K
AD  - Department of Pediatrics, School of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Baradaran Bagheri, Ali
AU  - Baradaran Bagheri A
AD  - Department of Neurosurgery, Madani Hospital, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Soleimani, Alireza
AU  - Soleimani A
AD  - Department of Infectious Disease, Alborz University of Medical Sciences, Karaj, 
      Iran.
FAU - Behzadian, Farida
AU  - Behzadian F
AD  - Department of Bioscience and Biotechnology, Malek Ashtar University of 
      Technology, Tehran, Iran.
FAU - Safavi, Mahshid
AU  - Safavi M
AD  - Student Research Center, Alborz University of Medical Sciences, Karaj, Iran.
FAU - Rezaei, Farhad
AU  - Rezaei F
AD  - Department of Virology, School of Public Health, Tehran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210623
PL  - Switzerland
TA  - Intervirology
JT  - Intervirology
JID - 0364265
SB  - IM
MH  - *Fatigue Syndrome, Chronic/epidemiology
MH  - *Herpesviridae
MH  - *Herpesvirus 6, Human
MH  - Humans
PMC - PMC8820437
OTO - NOTNLM
OT  - Chronic fatigue syndrome
OT  - Human herpesvirus 6
OT  - Meta-analysis
OT  - Systematic review
COIS- The authors declare no conflicts of interest relevant to this study.
EDAT- 2021/08/05 06:00
MHDA- 2022/01/20 06:00
PMCR- 2021/06/23
CRDT- 2021/08/04 20:20
PHST- 2021/03/23 00:00 [received]
PHST- 2021/06/17 00:00 [accepted]
PHST- 2021/08/05 06:00 [pubmed]
PHST- 2022/01/20 06:00 [medline]
PHST- 2021/08/04 20:20 [entrez]
PHST- 2021/06/23 00:00 [pmc-release]
AID - 000517930 [pii]
AID - int-0065-0049 [pii]
AID - 10.1159/000517930 [doi]
PST - ppublish
SO  - Intervirology. 2022;65(1):49-57. doi: 10.1159/000517930. Epub 2021 Jun 23.