PMID- 34348647 OWN - NLM STAT- MEDLINE DCOM- 20211227 LR - 20211227 IS - 1471-2261 (Electronic) IS - 1471-2261 (Linking) VI - 21 IP - 1 DP - 2021 Aug 4 TI - The prevalence, relative risk factors and MTHFR C677T genotype of H type hypertension of the elderly hypertensives in Shanghai, China: a cross-section study : Prevalence of H type hypertension. PG - 376 LID - 10.1186/s12872-021-02151-x [doi] LID - 376 AB - BACKGROUND: H type hypertension is defined as homocysteine (Hcy) >/= 10 mumol/L in combination with primary hypertension. Studies demonstrated that the existence of hyperhomocysteine (HHcy) in hypertensive exacerbates the poor outcome of cardiocerebral incidents. This study was to investigate the current epidemic situation of H type hypertension and determine the risk factors in order to find intervention targets for H type hypertensives. METHODS: We conducted a cross-sectional study using cluster sampling design in Shanghai, China from July 2019 and April 2020. 23,652 patients with primary hypertension were enrolled in this study. Their medical information was recorded, and the level of Hcy concentrations and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms were detected. RESULTS: In total, 22,731 of 23,652 patients were recorded. The mean age was 68.9 +/- 8.6 y and 43% were men. 80.0% of the enrolled patients had H type hypertension. The frequency of allele T was 40.9%, and the proportions of the CC, CT, and TT genotypes were 36.1%, 46.0%, and 17.9%, respectively. Compared with the TT genotype, the plasma Hcy concentration levels were lower in patients with the CC/CT genotype (18.96 +/- 13.48 mumol/L vs. 13.62 +/- 5.20/14.28 +/- 5.36, F = 75.04, p < 0.01). The risk for H type hypertension was higher in elderly people. Men had ~ 5.55-fold odds of H type hypertension compared with women. Patients with CT genotype and TT genotype had ~ 1.36- and ~ 2.76-fold odds of H type hypertension compared with those with CC genotype, respectively. Smoking and diabetes were not significantly associated with H type hypertension. CONCLUSIONS: The prevalence of H type hypertension in patients with primary hypertension was 80.0%, which was higher than the 75% found in prior report in China. Age, gender, and MTHFR C677T polymorphisms rather than smoking and diabetes were independently associated with H type hypertension. CI - (c) 2021. The Author(s). FAU - Qian, Xiao-Lin AU - Qian XL AD - Department of Cardiology, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, QingPu District Central Hospital Shanghai, Shanghai, China. FAU - Cao, Hong AU - Cao H AD - Department of Cardiology, QingPu District Jinze Community Health Center, Shanghai, China. FAU - Zhang, Jun AU - Zhang J AD - Department of Cardiology, QingPu District Xujing Community Health Center, Shanghai, China. FAU - Gu, Zhi-Hui AU - Gu ZH AD - Department of Cardiology, QingPu District Zhujiajiao Community Health Center, Shanghai, China. FAU - Tang, Wei-Qin AU - Tang WQ AD - Department of Cardiology, QingPu District Xianghuaqiao Community Health Center, Shanghai, China. FAU - Shen, Lei AU - Shen L AD - Department of Cardiology, QingPu District Yingpu Community Health Center, Shanghai, China. FAU - Hu, Jia-Lu AU - Hu JL AD - Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China. FAU - Yao, Zhi-Feng AU - Yao ZF AD - Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China. FAU - Zhang, Lei AU - Zhang L AD - Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China. FAU - Tang, Min-Na AU - Tang MN AD - Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China. FAU - Lv, Xu-Cheng AU - Lv XC AD - Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China. FAU - Zhou, Jun AU - Zhou J AD - Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China. FAU - Jin, Xue-Juan AU - Jin XJ AD - Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China. FAU - Hong, Bin AU - Hong B AD - Department of Cardiology, Shanghai Zhujiajiao People's Hospital, Shanghai, China. qingpuzhongxin@163.com. FAU - Cui, Zhao-Qiang AU - Cui ZQ AD - Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China. zhaoq_cui@163.com. FAU - Ge, Jun-Bo AU - Ge JB AD - Department of Cardiology, Shanghai Institute of Cardiovascular Disease and Zhongshan Hospital Fudan University, Shanghai, China. ge.junbo2@zs-hospital.sh.cn. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20210804 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 RN - 0LVT1QZ0BA (Homocysteine) RN - EC 1.5.1.20 (MTHFR protein, human) RN - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - China/epidemiology MH - Cross-Sectional Studies MH - Female MH - *Genotype MH - Homocysteine/*blood MH - Humans MH - Hyperhomocysteinemia/complications MH - Hypertension/*blood/*epidemiology/genetics MH - Male MH - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics MH - Middle Aged MH - Polymorphism, Genetic MH - Prevalence MH - Risk Factors PMC - PMC8336333 OTO - NOTNLM OT - H type hypertension OT - Hyperhomocysteinemia OT - MTHFR C677T OT - Prevalence OT - Risk factors COIS- The authors declare that they have no competing interests. EDAT- 2021/08/06 06:00 MHDA- 2021/12/28 06:00 PMCR- 2021/08/04 CRDT- 2021/08/05 05:30 PHST- 2021/01/03 00:00 [received] PHST- 2021/06/25 00:00 [accepted] PHST- 2021/08/05 05:30 [entrez] PHST- 2021/08/06 06:00 [pubmed] PHST- 2021/12/28 06:00 [medline] PHST- 2021/08/04 00:00 [pmc-release] AID - 10.1186/s12872-021-02151-x [pii] AID - 2151 [pii] AID - 10.1186/s12872-021-02151-x [doi] PST - epublish SO - BMC Cardiovasc Disord. 2021 Aug 4;21(1):376. doi: 10.1186/s12872-021-02151-x.